Results 51 to 60 of about 187,908 (321)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective The Gold Coast criteria permit diagnosis of amyotrophic lateral sclerosis (ALS) even without upper motor neuron (UMN) signs. However, whether ALS patients with UMN signs (ALSwUMN) and those without (ALSwoUMN) share similar characteristics and prognoses remains unclear.
Hee‐Jae Jung +7 more
wiley +1 more source
Brain-derived neurotrophic factor and its clinical applications
Medical Journal of Dr. D.Y. Patil Vidyapeeth, 2022 Brain-derived neurotrophic factor (BDNF) is a protein found in human beings. This protein is a member of the neurotrophic family of growth factors that relates to the canonical nerve growth factor (NGF). Its main biological process in human is on neurons
Rujittika Mungmunpuntipantip +1 more
doaj +1 more source
Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons [PDF]
, 2008 Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions.
Georgiev, Danko +3 more
core
Imbalance of p75(NTR)/TrkB protein expression in Huntington's disease: Implication for neuroprotective therapies [PDF]
, 2013 Neuroprotective therapies based on brain-derived neurotrophic factor (BDNF) administration have been proposed for Huntington's disease (HD) treatment. However, our group has recently reported reduced levels of TrkB in HD mouse models and HD human brain ...
Alberch, J. +5 more
core +1 more source
Brain-derived neurotrophic factor and schizophrenia
Psychiatric Genetics, 2019 The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. Brain-derived neurotrophic factor biosynthesis and secretion are chrono-topically regulated processes at the cellular level, accounting for specific ...
Pasquale, Di Carlo +2 more
openaire +3 more sources
Neuropsychiatric Symptoms Mimicking Dementia in a Patient Treated With Imatinib
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Tyrosine kinase inhibitors are the cornerstone of chronic myeloid leukemia treatment. Newer agents have more potency and a broader spectrum of action, but also a higher potential for neuropsychiatric side effects. We present a case of a patient on imatinib who developed progressive cognitive, mood, and behavioral alterations.
Ashley Jones +3 more
wiley +1 more source
Brain-Derived Neurotrophic Factor in Chronic Periodontitis
Mediators of Inflammation, 2014 Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophic factor family. Outside the nervous system, BDNF has been shown to be expressed in various nonneural tissues, such as periodontal ligament, dental pulp, and odontoblasts.
Jôice Dias Corrêa +8 more
doaj +1 more source
MANF: A New Player in the Control of Energy Homeostasis, and Beyond
Frontiers in Physiology, 2018 All human behaviors, including the control of energy homeostasis, are ultimately mediated by neuronal activities in the brain. Neurotrophic factors represent a protein family that plays important roles in regulating neuronal development, function, and ...
Su Yang, Shihua Li, Xiao-Jiang Li
doaj +1 more source
Depression in Adolescence and Brain-Derived Neurotrophic Factor
Frontiers in Molecular Neuroscience, 2022 The incidence of depression among adolescents has been rapidly increasing in recent years. Environmental and genetic factors have been identified as important risk factors for adolescent depression.
Boyoung Lee +3 more
doaj +1 more source
Combination Therapy With Fingolimod and Neural Stem Cells Promotes Functional Myelination [PDF]
, 2019 Myelination, which occurs predominantly postnatally and continues throughout life, is important for proper neurologic function of the mammalian central nervous system (CNS).
Ciric, Bogoljub +7 more
core +1 more source