Results 51 to 60 of about 236,444 (370)

Alginate-encapsulated brain-derived neurotrophic factor–overexpressing mesenchymal stem cells are a promising drug delivery system for protection of auditory neurons

Journal of Tissue Engineering, 2020
The cochlear implant outcome is possibly improved by brain-derived neurotrophic factor treatment protecting spiral ganglion neurons. Implantation of genetically modified mesenchymal stem cells may enable the required long-term brain-derived neurotrophic ...
Jana Schwieger, Anika Hamm, Michael M. Gepp, André Schulz, Andrea Hoffmann, Thomas Lenarz, Verena Scheper   +6 more
doaj   +1 more source

S100B protein, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor in human milk. [PDF]

PLoS ONE, 2011
Human milk contains a wide variety of nutrients that contribute to the fulfillment of its functions, which include the regulation of newborn development.
Ruisong Li, Wei Xia, Zhihong Zhang, Kun Wu   +3 more
doaj   +1 more source

Stress and glucocorticoids affect the expression of brain-derived neurotrophic factor and neurotrophin-3 mRNAs in the hippocampus

Journal of Neuroscience, 1995
Chronic stress produces structural changes and neuronal damage especially in the hippocampus. Because neurotrophic factors affect neuron survival, we questioned whether they might be relevant to the heightened vulnerability of hippocampal neurons ...
Mark A. Smith, Shinya Makino, R. Kvetňanský, Robert M. Post, Psy-Chiatry Branch   +4 more
semanticscholar   +1 more source

Genetically engineered mesenchymal stem cells as a proposed therapeutic for Huntington's disease. [PDF]

, 2011
There is much interest in the use of mesenchymal stem cells/marrow stromal cells (MSC) to treat neurodegenerative disorders, in particular those that are fatal and difficult to treat, such as Huntington's disease.
Annett, Geralyn, Bauer, Gerhard, Cary, Whitney, Dunbar, Gary, Kambal, Amal, Kim, Hyun Sook, McGee, Jeannine, Mitchell, Gaela-Marie, Nolta, Jan A, Olson, Scott D, Pollock, Kari, Stewart, Heather, Tempkin, Jeremy, Tempkin, Teresa, Wheelock, Vicki   +14 more
core   +3 more sources

Positive autoregulation of GDNF levels in the ventral tegmental area mediates long-lasting inhibition of excessive alcohol consumption. [PDF]

, 2011
Glial cell line-derived neurotrophic factor (GDNF) is an essential growth factor for the survival and maintenance of the midbrain dopaminergic (DA-ergic) neurons.
Ahmadiantehrani, S, Barak, S, Kharazia, V, Ron, D   +3 more
core   +3 more sources

Signaling pathways linking behavior to neurogenesis in healthy brain and disease [PDF]

, 2020
Self-repair of the adult brain is limited – most diseases lack effective therapy. In order to better understand how a regenerative response can be achieved, studying mechanisms shaping the neurogenic niche, from environmental factors to intrinsic ...
Klempin, Friederike
core   +1 more source

Neural stem cells over-expressing brain-derived neurotrophic factor promote neuronal survival and cytoskeletal protein expression in traumatic brain injury sites

Neural Regeneration Research, 2017
Cytoskeletal proteins are involved in neuronal survival. Brain-derived neurotrophic factor can increase expression of cytoskeletal proteins during regeneration after axonal injury.
Tao Chen, Yan Yu, Liu-jiu Tang, Li Kong, Cheng-hong Zhang, Hai-ying Chu, Liang-wei Yin, Hai-ying Ma   +7 more
doaj   +1 more source

Brain-Derived Neurotrophic Factor in Brain Disorders: Focus on Neuroinflammation

Molecular Neurobiology, 2018
Brain-derived neurotrophic factor (BDNF) is one of the most studied neurotrophins in the healthy and diseased brain. As a result, there is a large body of evidence that associates BDNF with neuronal maintenance, neuronal survival, plasticity, and ...
Bruno Lima Giacobbo, J. Doorduin, H. Klein, R. Dierckx, E. Bromberg, E. D. de Vries   +5 more
semanticscholar   +1 more source

Brain region–specific roles of brain-derived neurotrophic factor in social stress–induced depressive-like behavior

Neural Regeneration Research
Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral response. Recent studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific ...
Man Han, Deyang Zeng, Wei Tan, Xingxing Chen, Shuyuan Bai, Qiong Wu, Yushan Chen, Zhen Wei, Yufei Mei, Yan Zeng   +9 more
doaj   +1 more source

Brain-derived neurotrophic factor and coronary artery disease

Russian Open Medical Journal, 2022
Coronary artery disease (CAD) is defined as myocardial damage developing as a result of its organic and functional changes, and leading to impaired blood flow through the coronary arteries.
Oksana Yu. Kytikova, Tatyana P. Novgorodtseva, Yulia K. Denisenko, Marina V. Antonyuk, Tatyana A. Gvozdenko, Olga V. Atamas   +5 more
doaj   +1 more source