Results 141 to 150 of about 5,092,170 (312)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Beyond Rifampin: Evaluating Rifapentine and Rifabutin as Alternative Treatments for Tuberculous Meningitis. [PDF]

J Infect Dis
Chen X, Ruiz-Gonzalez CE, Masias-Leon Y, Singh M, Nino-Meza OJ, Peloquin CA, Artemov D, Jain SK.   +7 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ACSS2 Suppresses Ferroptosis to Drive Breast Cancer Brain Metastasis. [PDF]

Cancer Res
Young RG, Esquea EM, Ciraku L, Merzy J, Ahmed NN, Talarico AN, Karuppiah M, Medori SM, Warade RP, Gocal W, Dick A, Simone NL, Reginato MJ.   +12 more
europepmc   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

HIV Reservoirs in Brain parenchyma and Cerebrospinal Fluid During Suppressive ART: Same-Same or Very Different? [PDF]

Curr HIV/AIDS Rep
Angelovich TA, Jamal Eddine J, Chalmers EK, Byrnes SJ, Churchill MJ.   +4 more
europepmc   +1 more source

Brain

Scholarpedia, 2007
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and Are Clinically Relevant across Central Nervous System Disorders. [PDF]

Cancer Res
Alvaro-Espinosa L, Marquez-Galera A, Priego N, García-Calvo V, Perea-García M, Hernandez-Oliver C, Retana D, Sanchez O, de Pablos-Aragoneses A, García-Gómez P, Graña-Castro O, Lapuente-Santana Ó, Serrano-Ron L, Al-Shahrour F, Cayuela López A, Peset I, Megías D, Ola M, Varešlija D, Young LS, Martí-Mateos Y, Enríquez JA, Hernández-Encinas E, Blanco-Aparicio C, Soengas MS, Bernhagen J, Antón-Fernández A, Ávila J, Marchena MA, Torres M, de Castro F, Márquez-Ropero M, Sierra A, Lopez-Atalaya JP, RENACER Group, Valiente M.   +35 more
europepmc   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source