Results 11 to 20 of about 3,629,316 (298)

Smell and Stress Response in the Brain: Review of the Connection between Chemistry and Neuropharmacology

open access: yesMolecules, 2021
The stress response in the brain is not fully understood, although stress is one of the risk factors for developing mental disorders. On the other hand, the stimulation of the olfactory system can influence stress levels, and a certain smell has been ...
Y. Masuo   +3 more
semanticscholar   +1 more source

Tailoring Hydrophobicity of Thioflavin T to Optimize Aβ Fibril Bioimaging

open access: yesAdvanced NanoBiomed Research, 2023
Fluorescence imaging of amyloid beta (Aβ) polypeptide using a small‐molecule fluorophore is a practical system for Alzheimer's disease (AD) diagnosis in clinical and research fields. Herein, a molecular designing strategy for a new fluorogenic probe that
Zehra Zunbul   +7 more
doaj   +1 more source

Iron, Aging, and Neurodegeneration

open access: yesMetals, 2015
Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The
Dafina M. Angelova, David R. Brown
doaj   +1 more source

When mothers leave their mark

open access: yeseLife, 2019
Progeny can inherit parental experiences through altered brain chemistry.
Raquel Barajas-Azpeleta, Kausik Si
doaj   +1 more source

Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents

open access: yesMolecules, 2023
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical resection of the tumor, radiotherapy, and adjuvant chemotherapy with ...
Silvia Salerno   +5 more
doaj   +1 more source

Implication of Gut Microbiome in Brain Chemistry and Behavior

open access: yes, 2018
Human microbiome colonization starts during the birth and keeps modulating and establishing itself till adult stage. Advances in research techniques have shown evidences displaying the role of microbiome in brain and behavior development in addition to ...
R. Kumari, Nirmal Verma
semanticscholar   +1 more source

Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion

open access: yesNature Communications, 2021
Conventional upconversion nanoparticles (UCNPs) cannot activate multiple neuron populations independently using optogenetics. Here the authors report trichromatic UCNPs with excitation-specific luminescence to allow activation of three distinct neuronal ...
Xuan Liu   +14 more
doaj   +1 more source

Neonatal CSF Creatine Kinase and CP Risk

open access: yesPediatric Neurology Briefs, 1992
Creatine kinase brain isoenzyme (CK-BB) was examined in the cerebrospinal fluid of 150 neonates at the Departments of Pediatrics and Neonatal Medicine and Clinical Chemistry, University Hospital, Ghent, Belgium.
J Gordon Millichap
doaj   +1 more source

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

open access: yesiScience, 2018
Summary: We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its mitochondrial accumulation; this dramatically increases its potency and efficacy against highly metastatic lung cancer lines in vitro, and in orthotopic lung tumor ...
Jing Pan   +16 more
doaj   +1 more source

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

open access: yesLipids in Health and Disease, 2017
Background The novel compound XH601 is a synthesized derivative of formononetin. The present study was to investigate the hypolipidemia effect and potential mechanism of XH601.
Meng-Jie Zhao   +7 more
doaj   +1 more source

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