A novel 18F-labelled high affinity agent for PET imaging of the translocator protein [PDF]
, 2015 The translocator protein (TSPO) is an important target for imaging focal neuroinflammation in diseases such as brain cancer, stroke and neurodegeneration, but current tracers for non-invasive imaging of TSPO have important limitations.
Adele Blair +8 more
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Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion
Nature Communications, 2021 Conventional upconversion nanoparticles (UCNPs) cannot activate multiple neuron populations independently using optogenetics. Here the authors report trichromatic UCNPs with excitation-specific luminescence to allow activation of three distinct neuronal ...
Xuan Liu +14 more
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Neonatal CSF Creatine Kinase and CP Risk
Pediatric Neurology Briefs, 1992 Creatine kinase brain isoenzyme (CK-BB) was examined in the cerebrospinal fluid of 150 neonates at the Departments of Pediatrics and Neonatal Medicine and Clinical Chemistry, University Hospital, Ghent, Belgium.
J Gordon Millichap
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iScience, 2018 Summary: We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its mitochondrial accumulation; this dramatically increases its potency and efficacy against highly metastatic lung cancer lines in vitro, and in orthotopic lung tumor ...
Jing Pan +16 more
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Human central nervous system (CNS) ApoE isoforms are increased by age, differentially altered by amyloidosis, and relative amounts reversed in the CNS compared with plasma [PDF]
, 2016 The risk of Alzheimer's disease (AD) is highly dependent on apolipoprotein-E (apoE) genotype. The reasons for apoE isoform-selective risk are uncertain; however, both the amounts and structure of human apoE isoforms have been hypothesized to lead to ...
Baker-Nigh, Alaina T +11 more
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Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism
Lipids in Health and Disease, 2017 Background The novel compound XH601 is a synthesized derivative of formononetin. The present study was to investigate the hypolipidemia effect and potential mechanism of XH601.
Meng-Jie Zhao +7 more
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Toxins, 2023 Of the wide variety of toxic compounds produced by cyanobacteria, the neurotoxic amino acid β-N-methylamino-l-alanine (BMAA) has attracted attention as a result of its association with chronic human neurodegenerative diseases such as ALS and Alzheimer’s.
James S. Metcalf +4 more
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Preparation of Neurospora crassa mitochondria [PDF]
, 1978 The fungus Neurospora crassa represents a eukaryotic cell with high biosynthetic activities. Cell mass doubles in 2-4 hr during expone ntial growth , even in simple salt media with sucrose as the sole carbon source. The microorgani sm forms a mycelium of
Jacki +11 more
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The role of the Amyloid Precursor Protein mutations and PERK-dependent signaling pathways in the pathogenesis of Alzheimer’s disease [PDF]
, 2016 Alzheimer’s disease (AD) is a highly complex, progressive, age-related neurodegenerative human disease entity. The genetic basis of AD is strictly connected with occurrence of mutations in Amyloid Precursor (APP) gene on chromosome 21.
Diehl, J. Alan +5 more
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Louis Pasteur, molecular dissymmetry, therapeutic chemistry and neuropharmacology
Comptes Rendus Biologies, 2022 Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally.
Changeux, Jean-Pierre
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