Results 21 to 30 of about 221,465 (259)

Physical Organic Chemistry on the Brain

The Journal of Organic Chemistry, 1997
Abstract
openaire   +4 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Brain metastases: It takes two factors for a primary cancer to metastasize to brain

Frontiers in Oncology, 2022
Brain metastasis of a cancer is a malignant disease with high mortality, but the cause and the molecular mechanism remain largely unknown. Using the samples of primary tumors of 22 cancer types in the TCGA database, we have performed a computational ...
Dingyun Liu, Dingyun Liu, Jun Bai, Jun Bai, Qian Chen, Qian Chen, Renbo Tan, Renbo Tan, Zheng An, Zheng An, Jun Xiao, Jun Xiao, Yingwei Qu, Yingwei Qu, Ying Xu, Ying Xu   +15 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A novel proficiency test to assess the animal diagnostic investigation process in identifying an unknown toxicant

Toxicology Reports
Participation in Proficiency Tests (PTs) is an important component of quality assurance in testing laboratories. In a typical chemistry PT, blind-coded samples are sent to participants for analysis of specific chemical agents, and results are compared to
Andriy Tkachenko, Yang Chen, Marissa Petrey, Scott Fritz, Tim Walsh, David Rotstein, Megan R. Miller, Bruce Williams, Michael Dark, Matthew Kmet, Ravinder Reddy, Gregory Tyson, Sarah M. Nemser   +12 more
doaj   +1 more source

A delicate balance: Iron metabolism and diseases of the brain

Frontiers in Aging Neuroscience, 2013
Iron is the most abundant transition metal within the brain, and is vital for a number of cellular processes including neurotransmitter synthesis, myelination of neurons, and mitochondrial function.
Dominic J. Hare, Dominic J. Hare, Scott eAyton, Ashley I. Bush, Peng eLei   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Trafficking through the blood–brain barrier is directed by core and outer surface components of layer‐by‐layer nanoparticles

Bioengineering & Translational Medicine
Drug‐carrying nanoparticles are a promising strategy to deliver therapeutics into the brain, but their translation requires better characterization of interactions between nanomaterials and endothelial cells of the blood–brain barrier (BBB). Here, we use
Nicholas G. Lamson, Andrew J. Pickering, Jeffrey Wyckoff, Priya Ganesh, Elizabeth A. Calle, Joelle P. Straehla, Paula T. Hammond   +6 more
doaj   +1 more source