Results 11 to 20 of about 221,465 (259)

Neonatal CSF Creatine Kinase and CP Risk

Pediatric Neurology Briefs, 1992
Creatine kinase brain isoenzyme (CK-BB) was examined in the cerebrospinal fluid of 150 neonates at the Departments of Pediatrics and Neonatal Medicine and Clinical Chemistry, University Hospital, Ghent, Belgium.
J Gordon Millichap
doaj   +1 more source

Mitochondria-Targeted Honokiol Confers a Striking Inhibitory Effect on Lung Cancer via Inhibiting Complex I Activity

iScience, 2018
Summary: We synthesized a mitochondria-targeted honokiol (Mito-HNK) that facilitates its mitochondrial accumulation; this dramatically increases its potency and efficacy against highly metastatic lung cancer lines in vitro, and in orthotopic lung tumor ...
Jing Pan, Yongik Lee, Gang Cheng, Jacek Zielonka, Qi Zhang, Martina Bajzikova, Donghai Xiong, Shirng-Wern Tsaih, Micael Hardy, Michael Flister, Christopher M. Olsen, Yian Wang, Ole Vang, Jiri Neuzil, Charles R. Myers, Balaraman Kalyanaraman, Ming You   +16 more
doaj   +1 more source

Hypolipidemic effect of XH601 on hamsters of Hyperlipidemia and its potential mechanism

Lipids in Health and Disease, 2017
Background The novel compound XH601 is a synthesized derivative of formononetin. The present study was to investigate the hypolipidemia effect and potential mechanism of XH601.
Meng-Jie Zhao, Shan-Shan Wang, Yao Jiang, Ying Wang, Hong Shen, Pei Xu, Hua Xiang, Hong Xiao   +7 more
doaj   +1 more source

Near-infrared manipulation of multiple neuronal populations via trichromatic upconversion

Nature Communications, 2021
Conventional upconversion nanoparticles (UCNPs) cannot activate multiple neuron populations independently using optogenetics. Here the authors report trichromatic UCNPs with excitation-specific luminescence to allow activation of three distinct neuronal ...
Xuan Liu, Heming Chen, Yiting Wang, Yueguang Si, Hongxin Zhang, Xiaomin Li, Zhengcheng Zhang, Biao Yan, Su Jiang, Fei Wang, Shijun Weng, Wendong Xu, Dongyuan Zhao, Jiayi Zhang, Fan Zhang   +14 more
doaj   +1 more source

A Direct Analysis of β-N-methylamino-l-alanine Enantiomers and Isomers and Its Application to Cyanobacteria and Marine Mollusks

Toxins, 2023
Of the wide variety of toxic compounds produced by cyanobacteria, the neurotoxic amino acid β-N-methylamino-l-alanine (BMAA) has attracted attention as a result of its association with chronic human neurodegenerative diseases such as ALS and Alzheimer’s.
James S. Metcalf, Sandra Anne Banack, Peter B. Wyatt, Peter B. Nunn, Paul A. Cox   +4 more
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Louis Pasteur, molecular dissymmetry, therapeutic chemistry and neuropharmacology

Comptes Rendus Biologies, 2022
Louis Pasteur is celebrated as the founding father of microbiology. But he was a chemist by training and discovered molecular dissymmetry experimentally.
Changeux, Jean-Pierre
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

The promise of molecular science in brain health. What breakthroughs are anticipated in the next 20 years?

Cerebral Circulation - Cognition and Behavior
Brain health means optimal physiological brain function across the normal life-course. It encompasses not only healthy brain aging but also brain diseases, their diagnosis and treatment.
Atticus H Hainsworth, Thomas P Blackburn, Elizabeth M Bradshaw, Fanny M Elahi, Philip B Gorelick, Jeremy D Isaacs, Anders Wallin, Steven CR Williams   +7 more
doaj   +1 more source

Brain chemistry and behaviour

Psychological Medicine, 1980
SYNOPSISThe functional organization of chemically transmitting synapses in the brain are described with special emphasis on recent studies demonstrating the localization of different transmitters to specific anatomical circuitries. The use of pharmacological tools for manipulating levels of chemical transmitters is referred to briefly, but particular ...
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source