Results 41 to 50 of about 221,465 (259)
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Nature Communications, 2023 Oligodendrocytes have been increasingly shown to be involved in Alzheimer’s disease (AD). Here, the authors perform single-cell RNA-sequencing on APP NL-G-F mice and describe a disease-associated oligodendrocyte (DAO) population.
Hanseul Park +6 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Scientific ReportsMyotonia and paramyotonia congenita (PC) are rare neuromuscular disorders characterized by muscle stiffness that intensifies in cold environments. These disorders are associated with variants in the SCN4A gene, that encodes the alpha subunit of the ...
Quentin Plumereau +3 more
doaj +1 more source
iScience, 2020 Summary: Data-independent acquisition mass spectrometry (DIA-MS) is a powerful technique that enables relatively deep proteomic profiling with superior quantification reproducibility.
Ronghui Lou +8 more
doaj +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
PENGARUH PENDEKATAN BRAIN-BASED TEACHING TERHADAP HASIL BELAJAR KIMIA
Jurnal Inovasi Pendidikan Kimia, 2015 This study aimed to determine the effect of inquiry method assisted e-module on the student learning outcomes of chemistry. Population in this study is XI grader in Senior High School (SHS) in Kudus, school year 2011/2012.
Hermawan Agung Prasetya +1 more
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Addressing Math Deficits to Improve Chemistry Success [PDF]
Nonpartisan Education Review, 2020 The brain solves problems in structures termed "working memory." Between 2001 and 2010, cognitive experiments verified that at each step when solving a problem, working memory can hold only a few small elements of knowledge that are not well-memorized ...
Eric A. Nelson
doaj
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Surface chemistry governs cellular tropism of nanoparticles in the brain
Nature Communications, 2017 There have been numerous attempts to develop nanomaterials to reach cells of the central nervous system for drug delivery. Here, the authors investigate the cellular fate of polymer-based nanoparticles with varying surface chemistries after ...
Eric Song +9 more
doaj +1 more source