Results 61 to 70 of about 627,989 (344)
Cellular Models of Aggregation-Dependent Template-Directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer's Disease [PDF]
, 2015 Copyright © 2015, The American Society for Biochemistry and Molecular Biology. Acknowledgements-We thank Drs Timo Rager and Rolf Hilfiker (Solvias, Switzerland) for polymorph analyses.Peer reviewedPublisher ...
Clunas, Scott +14 more
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CHEMISTRY OF THE FILAMENTS AND TUBULES OF BRAIN [PDF]
Journal of Histochemistry & Cytochemistry, 1973 In this paper the main fibrous proteins of the nervous system are discussed from a biochemical standpoint. The biochemical properties of the proteins making up the neurofilaments and neurotubules are briefly reviewed and attention is turned to the assembly of supramolecular structures from tubulin, the microtubular protein.
openaire +2 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
L-Tetrahydropalamatine: A Potential New Medication for the Treatment of Cocaine Addiction [PDF]
, 2012 Levo-tetrahydropalmatine (l-THP) is an active constituent of herbal preparations containing plant species of the genera Stephania and Corydalis and has been approved and used in China for a number of clinical indications under the drug name Rotundine ...
Mantsch, John R., Wang, Jia Bei
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La scienza dell'amore e i suoi limiti
Rivista Internazionale di Filosofia e Psicologia, 2013 The Science of Love and its Limits - To investigate love as a natural phenomenon entails subjecting this aspect of human life – up till now considered evanescent, impalpable and deeply subjective – to the scrutiny and understanding of contemporary ...
Domenica Bruni
doaj +1 more source
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source
Prion protein interacts with bace1 and differentially regulates its activity towards wild type and swedish mutant amyloid precursor protein [PDF]
, 2011 In Alzheimer disease amyloid-β (Aβ) peptides derived from the amyloid precursor protein (APP) accumulate in the brain. Cleavage of APP by the β-secretase BACE1 is the rate-limiting step in the production of Aβ.
Andersen +49 more
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, 2020 Graph theory in the last two decades penetrated sociology, molecular biology, genetics, chemistry, computer engineering, and numerous other fields of science.
Grolmusz, Vince +2 more
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Scientific ReportsMyotonia and paramyotonia congenita (PC) are rare neuromuscular disorders characterized by muscle stiffness that intensifies in cold environments. These disorders are associated with variants in the SCN4A gene, that encodes the alpha subunit of the ...
Quentin Plumereau +3 more
doaj +1 more source
iScience, 2020 Summary: Data-independent acquisition mass spectrometry (DIA-MS) is a powerful technique that enables relatively deep proteomic profiling with superior quantification reproducibility.
Ronghui Lou +8 more
doaj +1 more source