Results 51 to 60 of about 3,629,316 (298)

Addressing Math Deficits to Improve Chemistry Success [PDF]

Nonpartisan Education Review, 2020
The brain solves problems in structures termed "working memory." Between 2001 and 2010, cognitive experiments verified that at each step when solving a problem, working memory can hold only a few small elements of knowledge that are not well-memorized ...
Eric A. Nelson
doaj  

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A Chronically Implantable Bidirectional Neural Interface for Non-human Primates

Frontiers in Neuroscience, 2017
Optogenetics has potential applications in the study of epilepsy and neuroprostheses, and for studies on neural circuit dynamics. However, to achieve translation to clinical usage, optogenetic interfaces that are capable of chronic stimulation and ...
Misako Komatsu, Eriko Sugano, Hiroshi Tomita, Naotaka Fujii   +3 more
doaj   +1 more source

Kynurenines increase MRS metabolites in basal ganglia and decrease resting-state connectivity in frontostriatal reward circuitry in depression

Translational Psychiatry, 2021
Inflammation is associated with the development of anhedonia in major depression (MD), but the pathway by which inflammatory molecules gain access to the brain and lead to anhedonia is not clear.
Xiangchuan Chen, Diana J. Beltran, Valeriya D. Tsygankova, Bobbi J. Woolwine, Trusharth Patel, Wendy Baer, Jennifer C. Felger, Andrew H. Miller, Ebrahim Haroon   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Surface chemistry governs cellular tropism of nanoparticles in the brain

Nature Communications, 2017
There have been numerous attempts to develop nanomaterials to reach cells of the central nervous system for drug delivery. Here, the authors investigate the cellular fate of polymer-based nanoparticles with varying surface chemistries after ...
Eric Song, Alice Gaudin, Amanda R. King, Young-Eun Seo, Hee-Won Suh, Yang Deng, Jiajia Cui, Gregory T. Tietjen, Anita Huttner, W. Mark Saltzman   +9 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Development of a halofluorocarbon, chromatography-free radiosynthesis of fluorine-18 difluorocarbene

EJNMMI Radiopharmacy and Chemistry
Background In recent years, the development of the [18F]difluoromethyl radical ([18F]2-((difluoromethyl)sulfonyl)benzo[d]thiazole, [18F]4), and [18F]difluorocarbene ([18F]1-chloro-4-((difluoromethyl)sulfonyl)benzene, [18F]10) prosthetic groups, has paved
Catherine G. F. Dickmann, Andrew D. Bond, Selena Milicevic Sephton, Franklin I. Aigbirhio   +3 more
doaj   +1 more source

Chemistry of Brain Activity [PDF]

Nature, 1967
Molecular Basis of Some Aspects of Mental Activity Edited by Otto Walaas. (Proceedings of a NATO Advanced Study Institute held at Drammen, Norway, August 2–14, 1965.) Vol. 1: Pp. xv + 476. (London: Academic Press, Inc. (London), Ltd.; New York: Academic Press, Inc., 1967.) 110s.
openaire   +1 more source