Results 81 to 90 of about 194,987 (288)

Fully Humanized Bispecific T Cell Engager Shows Potent Activity in Central Nervous System and Peripheral Tumors

Advanced Science, EarlyView.
This study reports the development of a fully humanized bispecific T cell engager targeting IL13RA2, a tumor‐associated antigen enriched in glioblastoma. This off‐the‐shelf immunotherapy drives potent, antigen‐dependent T cell activation and tumor killing, and prolongs survival in experimental GBM and other solid tumors models without detectable off ...
Joseph T. Duffy, Angela Martin‐Regalado, Benedikt E. Haupt, Jacob R. Pogue, Aditi Thakur, Manuel Fierro Cota, Markella Zannikou, Sol Misener, Vera P. Krymskaya, Kathleen McCortney, Jason Miska, Craig Horbinski, Dmitri Simberg, Maciej S. Lesniak, Charles D. James, Roger Stupp, Irina V. Balyasnikova   +16 more
wiley   +1 more source

Effect of long-term administration of AY-9944, an inhibitor of 7-dehydrocholesterol Δ7-reductase, on serum and tissue lipids in the rat

Journal of Lipid Research, 1968
The effect of long-term administration of AY-9944, a specific inhibitor of cholesterol biosynthesis, was examined in rats maintained on diets with low and high cholesterol and fat content.
D. Dvornik, P. Hill
doaj   +1 more source

Manipulation of lipid rafts in neuronal cells

, 2010
Lipid rafts are specialized plasma membrane micro-domains highly enriched in cholesterol, sphingolipids and glycosylphosphatidylinositol (GPI) anchored proteins.
Eckert, Gunter P.
core  

Bi-Lateral Changes to Hippocampal Cholesterol Levels During Epileptogenesis and in Chronic Epilepsy Following Focal-Onset Status Epilepticus in Mice

, 2012
Brain cholesterol homeostasis has been shown to be disrupted in neurodegenerative conditions such as Alzheimer\u27s and Huntington\u27s diseases. Investigations in animal models of seizure-induced brain injury suggest that brain cholesterol levels are ...
Henshall, David, Meaney, S, Jimenez-Mateos, EM, Engel, Tobias, Al-Aaudia, Reza, Heverin, M, Jimenez-Mateosa, Eva, Engel, T, Henshall, DC, Meaney, Steve, Heverin, Maura, Al-Saudi, R   +11 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

MALDI-MSI - Cholesterol in Mouse Brain

, 2020
MALDI-MSI study on cholesterol in brain by Angelini et al.
Roberto Angelini
core   +2 more sources

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

Disease Models & Mechanisms, 2012
Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and ...
Jean E. Vance
doaj   +1 more source

Characterization of the roles of neuronal cholesterol biosynthesis and ORP4 in hippocampal neurons and glia

, 2016
Cholesterol is an essential component of cell membranes and plays important roles in cell signalling. The brain contains a quarter of the body’s total cholesterol pool, all of which is synthesized in situ by neurons and glia, which are the structurally ...
Martin, Laura
core  

Cross‐Modal Denoising and Integration of Spatial Multi‐Omics Data with CANDIES

Advanced Science, EarlyView.
In this paper, we introduce CANDIES, which leverages a conditional diffusion model and contrastive learning to effectively denoise and integrate spatial multi‐omics data. We conduct extensive evaluations on diverse synthetic and real datasets, CANDIES shows superior performance on various downstream tasks, including denoising, spatial domain ...
Ye Liu, Wanpeng Zou, Yuekai Li, Jiayi Wang, Mingxuan Cai, Hongmin Cai   +5 more
wiley   +1 more source

Survival of adult neurons lacking cholesterol synthesis in vivo

BMC Neuroscience, 2007
Background Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the ...
Möbius Wiebke, Xiao Le, Saher Gesine, Fünfschilling Ursula, Nave Klaus-Armin   +4 more
doaj   +1 more source