Results 81 to 90 of about 2,101,293 (251)

Cholesterol intake and statin use regulate neuronal G protein-gated inwardly rectifying potassium channels

Journal of Lipid Research, 2019
Cholesterol, a critical component of the cellular plasma membrane, is essential for normal neuronal function. Cholesterol content is highest in the brain, where most cholesterol is synthesized de novo; HMG-CoA reductase controls the synthesis rate ...
Anna N. Bukiya, Paul S. Blank, Avia Rosenhouse-Dantsker   +2 more
doaj   +1 more source

Esterified Cholesterol Conjugates Enable LNP‐Mediated mRNA Delivery to the Blood–Brain Barrier Following Intravenous Administration

Advanced Materials, EarlyView.
A cholesterol‐conjugated lipid library enabled the identification of a ligand‐free LNP platform for efficient mRNA delivery to brain endothelial cells via systemic administration. This platform achieves selective BBB targeting without disrupting barrier integrity, and enables modulation of neuroinflammation and vascular function without requiring trans‐
Zeru Tian, Xu Wang, Alexis Pacheco Benitez, Erick Guerrero, Yaou Duan, Jingwen Wei, Lukas Farbiak, Daniel J. Siegwart   +7 more
wiley   +1 more source

Characterization of the roles of neuronal cholesterol biosynthesis and ORP4 in hippocampal neurons and glia

, 2016
Cholesterol is an essential component of cell membranes and plays important roles in cell signalling. The brain contains a quarter of the body’s total cholesterol pool, all of which is synthesized in situ by neurons and glia, which are the structurally ...
Martin, Laura
core  

Genetic Variation in FADS Genes and Plasma Cholesterol Levels in 2-Year-Old Infants [PDF]

, 2013
Single nucleotide polymorphisms (SNPs) in genes involved in fatty acid metabolism (FADS1 FADS2 gene cluster) are associated with plasma lipid levels. We aimed to investigate whether these associations are already present early in life and compare the ...
Moltó-Puigmartí Carolina, Penders, J., Ronald P Mensink, Carolina Moltó-Puigmartí (5261441), Jogchum Plat (302633), Thijs Carel, Monique Mommers, Thijs, Carel, Mommers, Monique, Eugène Jansen, Dirkje S Postma, Mensink Ronald P., John Penders (396322), Mommers Monique, Plat, J., Mensink, Ronald P., Koppelman, Gerard H., Standl Marie, Dirkje S. Postma (101740), Joachim Heinrich (60421), Postma, D.S., Jansen, Eugène, Standl, Marie, Moltó-Puigmartí, Carolina, Penders John, Koppelman Gerard H., Heinrich Joachim, Mensink, R.P., Thijs, C., Gerard H. Koppelman (153163), Postma, Dirkje S., Moltó-Puigmarti, C., Plat Jogchum, Carolina Moltó-Puigmartí, Carel Thijs (112720), Postma Dirkje S., Jansen, E., Joachim Heinrich, Marie Standl, Carel Thijs, Heinrich, Joachim, Jogchum Plat, Mommers, M., Standl, M., Monique Mommers (112709), Heinrich, J., Ronald P. Mensink (302629), Koppelman, Gerard H.; id_orcid, John Penders, Eugène Jansen (123572), Marie Standl (163136), Thijs, C.; id_orcid, Plat, Jogchum, Penders, John, Gerard H Koppelman, Koppelman, G.H., Jansen Eugène   +56 more
core   +3 more sources

Increasing Lipid Nanoparticle mRNA Copy Number Improves Transfection Potency

Advanced Materials, EarlyView.
As lipid nanoparticle (LNP) systems are the leading platform for in vivo nucleic acid delivery, improving transfection potency of these systems is of considerable interest. In this work, we explored a post‐mixing formulation method involving a two‐step buffer exchange that increased the number of mRNA copies within each LNP while reducing the number of
Yao Zhang, Jerry Leung, Judy Cheng, Arash Momeni, Albert Kamanzi, Ariadne Tuckmantel Bido, Suiyang Liao, Emma Kang, Colton Strong, Christian J. Kastrup, Sabrina Leslie, Miffy Hok Yan Cheng, Pieter R. Cullis   +12 more
wiley   +1 more source

Survival of adult neurons lacking cholesterol synthesis in vivo

BMC Neuroscience, 2007
Background Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the ...
Möbius Wiebke, Xiao Le, Saher Gesine, Fünfschilling Ursula, Nave Klaus-Armin   +4 more
doaj   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

Disease Models & Mechanisms, 2012
Dysregulation of cholesterol homeostasis in the brain is increasingly being linked to chronic neurodegenerative disorders, including Alzheimer’s disease (AD), Huntington’s disease (HD), Parkinson’s disease (PD), Niemann-Pick type C (NPC) disease and ...
Jean E. Vance
doaj   +1 more source

Mecanismos moleculares que relacionam a hipercolesterolemia familiar à doença de Alzheimer [PDF]

, 2015
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-Graduação em Bioquímica, Florianópolis, 2015.A hipercolesterolemia familiar é uma doença do metabolismo das lipoproteínas causada por anormalidades ...
Oliveira, Jade de
core  

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source