Results 101 to 110 of about 194,987 (288)

Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain

Journal of Lipid Research, 2004
The standard in vivo method to determine rates of brain cholesterol synthesis involves systemic injection of 3H2O and measurement of incorporated radioactivity in sterols.
R. Kennedy Keller, Michael Small, Steven J. Fliesler   +2 more
doaj   +1 more source

Role of cholesterol in modulating brain hyperexcitability

Epilepsia
AbstractCholesterol is a critical molecule in the central nervous system, and imbalances in the synthesis and metabolism of brain cholesterol can result in a range of pathologies, including those related to hyperexcitability. The impact of cholesterol on disorders of epilepsy and developmental and epileptic encephalopathies is an area of growing ...
James W. Wheless, Jong M. Rho
openaire   +2 more sources

Sterol Transport Protein ORP6 Regulates Astrocytic Cholesterol Metabolism and Brain Aβ Deposition

, 2023
The mammalian brain is the most cholesterol-rich organ of the body, requiring in situ de novo cholesterol synthesis to maintain its cholesterol requirement.
Vijithakumar, Viyashini
core   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Advanced Dental Composite Technology via Bisilanized Dual‐Action Nanofillers for Biofilm Control

Advanced Science, EarlyView.
A multimodal research strategy has led to the development of an innovative resin‐based composite (RBC) with dual antibacterial action. The S_CM‐RBC formula showed strong antibiofilm activity, excellent mechanical strength, and biosafety. It effectively controlled oral bacteria in prevention of caries recurrence, and maintained pulp health in a rat ...
Chenmin Yao, Line Etiennot, Naiera Zayed, Shengjie Liang, Mehraveh Saghi, Jelle Verdonck, Lingyue Liu, Fei Zhang, Wim Teughels, Cui Huang, Kirsten Van Landuyt, Bart Van Meerbeek   +11 more
wiley   +1 more source

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

Advanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng, Zhengqiang Wu, Yu Xiong, Zhongya Gao, Yishan Liu, Ziyi Wang, Haibin Wang, Chaofeng Han, Wenxiang Chu, Xuhua Lu   +9 more
wiley   +1 more source

A Microgel Platform Enables Site‐Specific Intestinal Delivery of Lactoferrin, Improving its Bioavailability for Targeted Alleviating Liver Injury and Colitis

Advanced Science, EarlyView.
This work first time reports an eco‐friendly desert plant food‐based polysaccharide ASKP microgels which have intestinal site‐specific release properties which can achieve small‐intestine or colon targeting capability via different cross‐linking chemistry.
Huiling Yan, Yixuan Li, Shanan Chen, Pengcheng Du, Kaiwen Wu, Hui Zhang, Kasper Hettinga, Lina Zhang, Gergely Toldi, Fazheng Ren, Yuan Li   +10 more
wiley   +1 more source

Cholesterol imbalance and neurotransmission defects in neurodegeneration

Experimental and Molecular Medicine
The brain contains the highest concentration of cholesterol in the human body, which emphasizes the importance of cholesterol in brain physiology. Cholesterol is involved in neurogenesis and synaptogenesis, and age-related reductions in cholesterol ...
Kyung Chul Shin, Houda Yasmine Ali Moussa, Yongsoo Park   +2 more
doaj   +1 more source

Age-dependent effect of high cholesterol diets on anxiety-like behavior in elevated plus maze test in rats

, 2014
Background: Cholesterol is an essential component of brain and nerve cells and is essential for maintaining the function of the nervous system. Epidemiological studies showed that patients suffering from anxiety disorders have higher serum cholesterol ...
Luo, Jia, Jin, Feng, Wang, Li, Liang, Shan, Li, Wei, Wu, Xiaoli, Wang, Tao, Hu, Xu   +7 more
core  

Cholesterol Metabolism in the Brain and Dementia [PDF]

, 2011
Introduction: Cholesterol metabolism in the brain is implicated in the development of Alzheimer's disease (AD). Understanding the relationship between markers of brain cholesterol metabolism and the structural changes occurring in the aging brain has ...
Hughes, Timothy Michael
core