Results 101 to 110 of about 2,101,293 (251)

Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications

Advanced Science, EarlyView.
Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee, SeongCheol Jang, Wangmyung Choi, Jaewon Park, Jaehyun Hur, Hocheon Yoo, Hyun‐Suk Kim   +6 more
wiley   +1 more source

Enzyme blockade: a nonradioactive method to determine the absolute rate of cholesterol synthesis in the brain

Journal of Lipid Research, 2004
The standard in vivo method to determine rates of brain cholesterol synthesis involves systemic injection of 3H2O and measurement of incorporated radioactivity in sterols.
R. Kennedy Keller, Michael Small, Steven J. Fliesler   +2 more
doaj   +1 more source

A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man [PDF]

, 2011
An increased plasma cholesterol concentration is associated with increased risk of cardiovascular disease. However, individuals vary largely in their response to cholesterol lowering drugs and 40% of them, do not reach their cholesterol-lowering target.
van de Pas, N., Pas, N., van de
core  

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

Advanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao, Na Zhou, Ruotong Liu, Xiaofei Li, Jian Li, Fuzhong Xue, Qingzhen Hou   +6 more
wiley   +1 more source

The relation between cholesterol and haemorrhagic or ischaemic stroke in the Renfrew/Paisley study [PDF]

, 2000
Studies have found little association between cholesterol and overall stroke risk, but this could be attributable to different relations for haemorrhagic and ischaemic stroke.
Hole, D.J., Davey Smith, G., Hart, C.L.
core   +1 more source

Neuromorphic Devices and Computing for Sensing, Memory, and Control

Advanced Science, EarlyView.
This review introduces neuromorphic devices made from diverse materials. These devices mimic neuronal functions and architectures and, when integrated with artificial or biological computing, can form closed loops with neurons for pressure, optical, acoustic, and biochemical sensing and modulation.
Zhengguang Zhu, Nicholas Schaffer, Xiao Yang   +2 more
wiley   +1 more source

Cholesterol imbalance and neurotransmission defects in neurodegeneration

Experimental and Molecular Medicine
The brain contains the highest concentration of cholesterol in the human body, which emphasizes the importance of cholesterol in brain physiology. Cholesterol is involved in neurogenesis and synaptogenesis, and age-related reductions in cholesterol ...
Kyung Chul Shin, Houda Yasmine Ali Moussa, Yongsoo Park   +2 more
doaj   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress

Journal of Nanobiotechnology
Cholesterol plays a crucial role in regulating synaptic membrane fluidity and ion channels. Due to the blood-brain barrier, cholesterol in the brain is primarily self-synthesized by astrocytes.
Lei Tian, Yizhe Wei, Jianping Ma, Yiming Zhao, Yanan Mi, Leili Zhang, Bingyan Wang, Jiang Chen, Kang Li, Yue Shi, Wenqing Lai, Huanliang Liu, Bencheng Lin   +12 more
doaj   +1 more source

Cholesterol metabolism: physiological versus pathological aspects in intracerebral hemorrhage

Neural Regeneration Research
Cholesterol is an important component of plasma membranes and participates in many basic life functions, such as the maintenance of cell membrane stability, the synthesis of steroid hormones, and myelination.
Ruoyu Huang, Qiuyu Pang, Lexin Zheng, Jiaxi Lin, Hanxi Li, Lingbo Wan, Tao Wang   +6 more
doaj   +1 more source