Results 81 to 90 of about 5,759,332 (341)

Possible role of human ribonuclease dicer in the regulation of R loops

open access: yesFEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik   +2 more
wiley   +1 more source

A Thomistic Understanding of Human Death [PDF]

open access: yes, 2005
Post-printI will review higher-brain and whole-brain death from the standpoint of Thomas Aquinas’s metaphysical understanding of human nature. I will critique arguments for higher-brain death being a proper interpretation of Aquinas’s views and make a ...
Eberl, Jason T.
core  

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

open access: yesFEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei   +7 more
wiley   +1 more source

Cytochrome P450 oxidoreductase participates in nitric oxide consumption by rat brain [PDF]

open access: yes, 2009
In low nanomolar concentrations, NO (nitric oxide) functions as a transmitter in brain and other tissues, whereas near-micromolar NO concentrations are associated with toxicity and cell death.
Garthwaite, J., Hall, C.N., Keynes, R.G.
core   +3 more sources

Brain Death in Islamic Jurisprudence

open access: yesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2016
BACKGROUND AND OBJECTIVE: In today's world, Islamic jurisprudence encounters  new issues. One of the areas where jurisprudence gets involved is the issues concerned with brain death, whether brain death in jurisprudence and Islamic law is considered the ...
A Nikzad, GA Jorsaraei
doaj  

Knowledge, attitude, and perception on organ donation among undergraduate medical and nursing students at a tertiary care teaching hospital in the southern part of India: A cross-sectional study

open access: yesJournal of Education and Health Promotion, 2019
BACKGROUND: Organ donation is considered to be a noble act. Medical and nursing students will be the major healthcare providers in this field in the future.
Britzer Paul Vincent   +3 more
doaj   +1 more source

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

open access: yesFEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran   +3 more
wiley   +1 more source

Reply to Melissa Moschella [PDF]

open access: yes, 2016
Professor Moschella begins by discussing confusions in the brain death debate surrounding the use of the concepts of “integration” and “wholeness.” Some scholars, she says, such as Alan Shewmon, take the presence of biological integration as an ...
Brugger, E
core   +1 more source

Legal dilemmas of maternal brain death: The case of Marlise Muñoz [PDF]

open access: yesGlasnik Advokatske komore Vojvodine, 2020
The subject of this article is a case that occurred in Texas in 2013, which has caused great debate between medical and legal professionals, and has stirred public concern.
Drljača Jagoda V.
doaj  

Experimental Rat Model for Brain Death Induction and Kidney Transplantation

open access: yesJournal of Investigative Surgery, 2020
Background: Experimental animal research has been pivotal in developing clinical kidney transplantation (KTx). One donor-associated risk factor with negative affect of transplantation outcome is brain death (BD).
Majid Esmaeilzadeh   +6 more
doaj   +1 more source

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