Results 81 to 90 of about 1,696,584 (309)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Brain death: concepts and knowledge amongst health professionals in province of Sindh, Pakistan [PDF]

, 2008
OBJECTIVE: Last few decades have seen improved resuscitative measures and use of life saving machines like ventilators. Due to these dramatic interventions, end of life decisions, including brain death and organ transplantation, have become more complex ...
Khealani, Bhojo A, Patel, Junaid, Qamarunnisa,, Rath, Suresh, Sheerani, Mughis, Urfy, Mian Zainul Sajadeen   +5 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Knowledge, attitude, and perception on organ donation among undergraduate medical and nursing students at a tertiary care teaching hospital in the southern part of India: A cross-sectional study

Journal of Education and Health Promotion, 2019
BACKGROUND: Organ donation is considered to be a noble act. Medical and nursing students will be the major healthcare providers in this field in the future.
Britzer Paul Vincent, Gunjan Kumar, Sreejith Parameswaran, Sitanshu Sekar Kar   +3 more
doaj   +1 more source

S100B Protein as a Post-traumatic Biomarker for Prediction of Brain Death in Association With Patient Outcomes [PDF]

, 2013
Background: S100B is a calcium-binding protein, belonging to the S100 family proteins which are characterized by their high solubility and, currently, comprises 21 members which are expressed in a cell-specific manner.
Mahdkhah, A., Panahi, F., Shakeri, M.
core  

Quality of life (QoL) as predictive mediator variable for survival in patients with intracerebral neoplasma during radiotherapy [PDF]

, 2003
Background: The prognosis for patients with malignant astrocytoma or brain metastases is often fatal despite intensive therapy. Therefore we wished to elucidate whether the quality of life (QoL) is a determinant of overall survival (OAS).
Aydemir, U., Dühmke, Eckhart, Herschbach, P., Hollenhorst, H., Lenk, M., Schymura, B., Sehlen, Susanne   +6 more
core   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source

The Importance of Caring for Brain Death Patients Candidate for Organ Donation: A Qualitative Study

نشریه پرستاری ایران, 2022
Background & Aims: Caring for patients with the diagnosis of brain death is one of the heaviest duties for nurses. The importance of organ donation is one of the biggest challenges of nursing in the intensive care unit. This qualitative research aimed to
Hamideh Yazdimoghaddam, Zahra Sadat Manzari, Abas Heydari, Esa Mohammadi, Ibrahim Khaleghi   +4 more
doaj  

The Experiences of Family Members of Non-Organ Donors on the Crisis Rising From Patients' Brain Death [PDF]

, 2017
Background: Brain death crisis as an overwhelming situation can create a critical state for families in which they are unable to make logical decisions for their patients with brain death.
Abedi, H. A., Tahrekhani, M.
core  

Regression/eradication of gliomas in mice by a systemically-deliverable ATF5 dominant-negative peptide. [PDF]

, 2016
Malignant gliomas have poor prognosis and urgently require new therapies. Activating Transcription Factor 5 (ATF5) is highly expressed in gliomas, and interference with its expression/function precipitates targeted glioma cell apoptosis in vitro and in ...
Angelastro, James, Arias, Angelo, Cates, Charles, Cayanan, Geraldine, Fung, Jennifer, Greene, Lloyd, Karpel-Massler, Georg, Lamé, Michael, Nakayama Wong, Lynn, Rowland, Douglas, Sidorov, Maxim, Siegelin, Markus   +11 more
core   +2 more sources