Results 61 to 70 of about 338,090 (265)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Brain JNK and metabolic disease.

, 2021
Obesity, which has long since reached epidemic proportions worldwide, is associated with long-term stress to a variety of organs and results in diseases including type 2 diabetes. In the brain, overnutrition induces hypothalamic stress associated with the activation of several signalling pathways, together with central insulin and leptin resistance ...
Nogueiras, Rubén, Sabio, Guadalupe
openaire   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Sex-specific metabolic alterations in the type 1 diabetic brain of mice revealed by an integrated method of metabolomics and mixed-model

Computational and Structural Biotechnology Journal, 2020
Type 1 diabetes (T1D) can cause brain region-specific metabolic disorders, but whether gender influences T1D-related brain metabolic changes is rarely reported.
Qiaoying Jiang, Hangying Xu, Junjie Yan, Qingqing Xu, Yafei Zheng, Chen Li, Liangcai Zhao, Hongchang Gao, Hong Zheng   +8 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Clinical performance evaluation of the SiJoy GS1 continuous glucose monitor during oral glucose tolerance testing in healthy adults

Frontiers in Endocrinology
ObjectiveThis study evaluated the performance of the SiJoy GS1 Continuous Glucose Monitor (CGM) system by analyzing the time lag between plasma glucose (PG) and CGM measurements during an Oral Glucose Tolerance Test (OGTT) in healthy adults.
Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Wanyi Zhao, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Dongmei Zheng, Xianbao Shi, Feng Xu, Feng Xu, Lin Chen, Lin Chen, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xingmei Liu, Xiaolong Jin, Xiaolong Jin, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Qingbo Guan, Chao Xu, Chao Xu, Chao Xu, Chao Xu, Chao Xu   +30 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Hemoglobin is associated with BMDs and risk of the 10-year probability of fractures in patients with type 2 diabetes mellitus

Frontiers in Endocrinology
PurposeThis study aimed to investigate the associations between hemoglobin (HGB) levels and bone mineral density (BMD) and fracture risk in type 2 diabetes mellitus(T2DM) population of different ages.
Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Ren-xuan Li, Na Xu, Na Xu, Na Xu, Na Xu, Na Xu, Na Xu, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yu-ning Guo, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan Wang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Yan-wei Liang, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Xiao-lian Zhou, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Wen-tong Jiang, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Jian-xia Wei, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Xin-yuan Zhang, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Li-na Zhou, Lei Zhu, Yan-man Zhou, Yan-man Zhou, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu, Jin Xu   +73 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source