Results 1 to 10 of about 79,934 (285)
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Molecular Metabolism, 2016 Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether ...
Paula Mera +2 more
exaly +4 more sources
Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A [PDF]
International Journal of Endocrinology, 2021 Osteocalcin is a bone-derived hormone that plays an important role in the crosstalk between bone and energy metabolism. Previous studies have found that treatment with uncarboxylated osteocalcin can protect mice from high-fat diet-induced nonalcoholic ...
Mingliang Zhang +6 more
doaj +3 more sources
Osteocalcin: Beyond Bones [PDF]
Endocrinology and MetabolismApart from basic roles such as supporting the body, protecting internal organs, and storing calcium, the skeletal system also performs hormonal functions. In recent years, several reports have been published on proteins secreted by bones and their impact
Jakub Krzysztof Nowicki +1 more
doaj +2 more sources
Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones
Frontiers in Endocrinology, 2021 In addition to its structural role, the skeleton serves as an endocrine organ that controls mineral metabolism and energy homeostasis. Three major cell types in bone - osteoblasts, osteoclasts, and osteocytes – dynamically form and maintain bone and ...
Jialiang S. Wang +4 more
doaj +2 more sources
Scientific Reports, 2017 Osteocalcin has been considered to be an important regulator of energy metabolism in type 2 diabetes mellitus (T2DM). However, the mechanism underlying the involvement of uncarboxylated osteocalcin in the vascular complications of T2DM is not fully ...
Qinyue Guo +5 more
doaj +2 more sources
Disease Models & Mechanisms, 2016 Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the
Laura J. Lambert +10 more
doaj +2 more sources
Osteocalcin and serum insulin-like growth factor-1 as biochemical skeletal maturity indicators
Progress in Orthodontics, 2017 Background With change in concepts of growth determination methods, there is a surge in the measurement of biomarkers for appraisal of growth status. Osteocalcin is a bone-specific protein and was observed to parallel the normal growth curve.
Tulika Tripathi +5 more
doaj +2 more sources
Osteocalcin: A Multifaceted Bone-Derived Hormone
Annual review of nutrition, 2023 Together, loss- and gain-of-function experiments have identified the bone-derived secreted molecule osteocalcin as a hormone with a broad reach in rodents and primates.
G. Karsenty
semanticscholar +1 more source
Science Advances, 2021 Osteocalcin regulating oligodendrocyte myelination is mediated by GPR37, a novel receptor for osteocalcin in the CNS.
Zhengjiang Qian +7 more
semanticscholar +1 more source
International Journal of Endocrinology, 2021 Previous studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population.
Xiaomin Nie +5 more
doaj +1 more source