Results 31 to 40 of about 43,856 (265)

Osteocalcin and Metabolic Syndrome

Clinical Medicine Insights: Endocrinology and Diabetes, 2023
Introduction: Metabolic syndrome which is a syndrome complex that is associated with insulin resistance. Osteocalcin (OC), a bone derived protein has been found to decrease insulin resistance and stimulate production of insulin from the pancreas.
Aaditya Viswanath, Sudha Vidyasagar, Cynthia Amrutha Sukumar   +2 more
openaire   +3 more sources

Undercarboxylated osteocalcin reverts insulin resistance induced by endoplasmic reticulum stress in human umbilical vein endothelial cells

Scientific Reports, 2017
Osteocalcin has been considered to be an important regulator of energy metabolism in type 2 diabetes mellitus (T2DM). However, the mechanism underlying the involvement of uncarboxylated osteocalcin in the vascular complications of T2DM is not fully ...
Qinyue Guo, Huixia Li, Lin Xu, Shufang Wu, Hongzhi Sun, Bo Zhou   +5 more
doaj   +1 more source

Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance. [PDF]

PLoS ONE, 2013
BACKGROUND: Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood.
Martí Juanola-Falgarona, José Cándido-Fernández, Jordi Salas-Salvadó, Miguel A Martínez-González, Ramón Estruch, Miquel Fiol, Victoria Arija-Val, Mònica Bulló, PREDIMED Study Investigators   +8 more
doaj   +1 more source

Osteocalcin is necessary and sufficient to maintain muscle mass in older mice

Molecular Metabolism, 2016
Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether ...
Paula Mera, Kathrin Laue, Jianwen Wei, Julian Meyer Berger, Gerard Karsenty   +4 more
doaj   +1 more source

Circulating osteocalcin is associated with time in range and other metrics assessed by continuous glucose monitoring in type 2 diabetes

Diabetology & Metabolic Syndrome, 2022
Background Osteocalcin, a protein secreted mainly by mature osteoblasts, has been shown to be involved in glucose metabolism through various pathways.
Jun Liu, Yinghua Wei, Pu Zang, Wei Wang, Zhouqin Feng, Yanyu Yuan, Hui Zhou, Zhen Zhang, Haiyan Lei, Xinyi Yang, Jun Liu, Bin Lu, Jiaqing Shao   +12 more
doaj   +1 more source

Interactions between Serum Adipokines and Osteocalcin in Older Patients with Hip Fracture

International Journal of Endocrinology, 2012
Introduction. Experiments on genetically modified animals have discovered a complex cross-regulation between adipokines (leptin, adiponectin) and osteocalcin. The relationships between these molecules in human osteoporosis are still unclear. We evaluated
Alexander Fisher, Wichat Srikusalanukul, Michael Davis, Paul Smith   +3 more
doaj   +1 more source

Biomarkers of vascular calcification: their relationship with diseases of the cardiovascular system and their importance in clinical practice

Атеросклероз, 2021
The literature review highlights the results of the most recent foreign and Russian studies on topical problems of vascular calcification with an emphasis on the relationship between some biochemical markers of vascular calcification (in priority ...
N. A. Maslatsov, Yu. I. Ragino
doaj   +1 more source

Osteocalcin Alleviates Nonalcoholic Fatty Liver Disease in Mice through GPRC6A

International Journal of Endocrinology, 2021
Osteocalcin is a bone-derived hormone that plays an important role in the crosstalk between bone and energy metabolism. Previous studies have found that treatment with uncarboxylated osteocalcin can protect mice from high-fat diet-induced nonalcoholic ...
Mingliang Zhang, Xiaomin Nie, Yeqing Yuan, Yansu Wang, Xiaojing Ma, Jun Yin, Yuqian Bao   +6 more
doaj   +1 more source

Metabolic Phenotypes and Step by Step Evolution of Type 2 Diabetes: A New Paradigm

Biomedicines, 2021
Unlike bolus insulin secretion mechanisms, basal insulin secretion is poorly understood. It is essential to elucidate these mechanisms in non-hyperinsulinaemia healthy persons.
Isabella D. Cooper, Kenneth H. Brookler, Yvoni Kyriakidou, Bradley T. Elliott, Catherine A. P. Crofts   +4 more
doaj   +1 more source

Effect of Obesity and Osteocalcin on Brain Glucose Metabolism in Healthy Participants

Brain Sciences, 2023
We evaluated the effects of obesity and osteocalcin on glucose metabolism in the brain. A total of 179 healthy men were enrolled in this study. After preprocessing positron emission tomography images, including by performing coregistration, spatial ...
Seunghyeon Shin, Hyun-Yeol Nam
doaj   +1 more source