Results 31 to 40 of about 79,934 (285)
Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function
The Journal of Clinical Investigation, 2022 Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland–derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss.
Typhanie Dumontet, Gary D. Hammer
doaj +1 more source
Osteocalcin immunostaining. [PDF]
, 2019 Two weeks after the surgery of the (A) control group; (B) ADSC sheet group; and (C) osteogenic-induced ADSC sheet group; original magnification X400.
Hidenori Matsubara (524500) +7 more
core +1 more source
Association between serum ferritin and osteocalcin as a potential mechanism explaining the iron-induced insulin resistance. [PDF]
PLoS ONE, 2013 BACKGROUND: Increased iron stores are associated with increased risk of type 2 diabetes, however, the mechanisms underlying these associations are poorly understood.
Martí Juanola-Falgarona +8 more
doaj +1 more source
HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]
, 2007 HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
van Wijnen, AJ +19 more
core +3 more sources
Osteocalcin—A Versatile Bone-Derived Hormone
Frontiers in Endocrinology, 2019 Bone has long been regarded as a static organ, simply providing protection and support. However, this mindset has changed radically in recent years and bone is becoming increasingly recognized for its endocrine function of secreting several hormones ...
Sarah C. Moser, Bram C J van der Eerden
semanticscholar +1 more source
Osteocalcin, energy and glucose metabolism [PDF]
, 2014 Osteocalcin is a bone matrix protein that has been associated with several hormonal actions on energy and glucose metabolism. Animal and experimental models have shown that osteocalcin is released into the bloodstream and exerts biological effects on ...
Zanatta,Leila C. B. +7 more
core +1 more source
Journal of Bone and Mineral Research, 2020 Osteocalcin regulates energy metabolism in an active undercarboxylated/uncarboxylated form. However, its role on the development of non‐alcoholic fatty liver disease (NAFLD) is still controversial.
Mingfeng Xia +19 more
semanticscholar +1 more source
Immunohistological staining for Osteocalcin. [PDF]
, 2013 (a) Osteocalcin-positive cells in an ossicle of new bone adjacent to nanofiber scaffold in a defect implanted with PLLA/BMP-2 after 8 weeks. (b) Negative control for osteocalcin from the center of the same defect (DAB-Hematoxylin, BF).
Sonja Schlimme (343135) +10 more
core +1 more source
Diabetology & Metabolic Syndrome, 2022 Background Osteocalcin, a protein secreted mainly by mature osteoblasts, has been shown to be involved in glucose metabolism through various pathways.
Jun Liu +12 more
doaj +1 more source
Gpr158 mediates osteocalcin’s regulation of cognition
Journal of Experimental Medicine, 2017 That osteocalcin (OCN) is necessary for hippocampal-dependent memory and to prevent anxiety-like behaviors raises novel questions. One question is to determine whether OCN is also sufficient to improve these behaviors in wild-type mice, when circulating ...
L. Khrimian +13 more
semanticscholar +1 more source