Results 21 to 30 of about 43,856 (265)

Osteocalcin inhibits myocyte aging through promotion of starvation-induced autophagy via IL-6/STAT3 signaling

open access: yesExperimental Gerontology, 2023
This study aimed to investigate the effects and mechanisms of osteocalcin on autophagy in myoblasts, as well as its possible therapeutic effects in aging muscle.
Pengying Gu   +6 more
doaj   +1 more source

Osteocalcin and the physiology of danger [PDF]

open access: yesFEBS Letters, 2022
Bone biology has long been driven by the question as to what molecules affect cell differentiation or the functions of bone. Exploring this issue has been an extraordinarily powerful way to improve our knowledge of bone development and physiology.
Julian Meyer Berger, Gerard Karsenty
openaire   +2 more sources

Between-subject and within-subject variability in measures of biochemical markers of bone turnover in cynomolgus and rhesus macaques

open access: yesBone Reports, 2021
Development of optimal bone mass during early adulthood is determined by the balance between bone formation and resorption. The utility of minimally invasive biomarkers for monitoring bone turnover balance in maturing non-human primates has received ...
Lara H. Sattgast   +6 more
doaj   +1 more source

Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study

open access: yesCardiovascular Diabetology, 2022
Background The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data.
Yun Shen   +9 more
doaj   +1 more source

Glucose Tolerance Tests and Osteocalcin Responses in Healthy People

open access: yesFrontiers in Endocrinology, 2018
Aim: Osteocalcin and undercarboxylated osteocalcin are suggested to be endocrine messengers from the bones and have been shown to stimulate insulin secretion from pancreatic β-cells.
Jakob Starup-Linde   +9 more
doaj   +1 more source

Serum osteocalcin levels in overweight children [PDF]

open access: yesAnnals of Pediatric Endocrinology & Metabolism, 2019
Purpose Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure ...
Seok Bin Oh   +4 more
doaj   +1 more source

The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

open access: yesInternational Journal of Endocrinology, 2013
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c ...
Qingqing Wang   +4 more
doaj   +1 more source

Bones and adrenal organogenesis: how embryonic osteocalcin influences lifelong adrenal function

open access: yesThe Journal of Clinical Investigation, 2022
Osteocalcin is a hormone produced in bones by osteoblasts during bone formation. Numerous studies have demonstrated that adrenal gland–derived glucocorticoids inhibit osteocalcin production, which can ultimately cause deleterious bones loss.
Typhanie Dumontet, Gary D. Hammer
doaj   +1 more source

Increased trabecular bone and improved biomechanics in an osteocalcin-null rat model created by CRISPR/Cas9 technology

open access: yesDisease Models & Mechanisms, 2016
Osteocalcin, also known as bone γ-carboxyglutamate protein (Bglap), is expressed by osteoblasts and is commonly used as a clinical marker of bone turnover. A mouse model of osteocalcin deficiency has implicated osteocalcin as a mediator of changes to the
Laura J. Lambert   +10 more
doaj   +1 more source

Relation between osteocalcin and the energy metabolism in obesity [PDF]

open access: yesVojnosanitetski Pregled, 2019
Background/Aim. Numerous findings have indicated the potential relation between the osteocalcin, the traditional parameter of bone turnover and the regulation of energy metabolism.
Nikolić Stanislava   +5 more
doaj   +1 more source

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