Results 21 to 30 of about 79,934 (285)

Osteocalcin is necessary for the alignment of apatite crystallites, but not glucose metabolism, testosterone synthesis, or muscle mass

PLoS Genetics, 2020
The strength of bone depends on bone quantity and quality. Osteocalcin (Ocn) is the most abundant noncollagenous protein in bone and is produced by osteoblasts.
T. Moriishi, Ryosuke Ozasa, Takuya Ishimoto, T. Nakano, Tomoka Hasegawa, T. Miyazaki, Wenguang Liu, R. Fukuyama, Yuying Wang, Hisato Komori, Xin Qin, N. Amizuka, T. Komori   +12 more
semanticscholar   +1 more source

Between-subject and within-subject variability in measures of biochemical markers of bone turnover in cynomolgus and rhesus macaques

Bone Reports, 2021
Development of optimal bone mass during early adulthood is determined by the balance between bone formation and resorption. The utility of minimally invasive biomarkers for monitoring bone turnover balance in maturing non-human primates has received ...
Lara H. Sattgast, Adam J. Branscum, Vanessa A. Jimenez, Natali Newman, Kathleen A. Grant, Russell T. Turner, Urszula T. Iwaniec   +6 more
doaj   +1 more source

Endothelium-specific depletion of LRP1 improves glucose homeostasis through inducing osteocalcin

Nature Communications, 2021
The vascular endothelium is present within metabolic organs and actively regulates energy metabolism. Here we show osteocalcin, recognized as a bone-secreted metabolic hormone, is expressed in mouse primary endothelial cells isolated from heart, lung and
Hua Mao, Luge Li, Qiying Fan, Aude Angelini, P. Saha, C. Coarfa, K. Rajapakshe, D. Perera, Jizhong Cheng, Huaizhu Wu, C. Ballantyne, Zheng Sun, Liang Xie, Xinchun Pi   +13 more
semanticscholar   +1 more source

Osteocalcin promotes bone mineralization but is not a hormone

PLoS Genetics, 2020
During the last 24 years the bone and mineral metabolism research community (and the National Institutes of Health and numerous other national and international funding agencies that support it) have devoted a great deal of intellectual energy and ...
S. Manolagas
semanticscholar   +1 more source

Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes [PDF]

, 2013
Contains fulltext : 125353.pdf (Publisher’s version ) (Open Access)BACKGROUND: Vitamin D supplementation in childhood improves the achievement of peak bone mass.
Crinò, A, Napoli N, Strollo R, Maurizi, Ar, Anguissola, Gb, Benevento, D, Rocky Strollo, Moretti, C, Paolo Pozzilli, Napoli, N, Maggi, D., CAVALLO, Maria Gisella, Carla Bizzarri, Portuesi, R, Cassone Faldetta, Mr, Cipponeri, E, Astorri, E, Manfrini, S, Schwartz, A., Guglielmi, C, Matteoli, Mc, Maddaloni, E., BUZZETTI, Raffaella, Pozzilli, P., Bizzarri, C., et al., Grp, IMDIAB, Spera, S, Pitocco, D, Ghirlanda, G, Di Stasio, E, Beretta Anguissola, G, Ernesto Maddaloni, Ann Schwartz, Maggi, D, Valente, L., Strollo, R, Cipolloni, L, BARCHETTA, ILARIA, Silvia Manfrini, Maddaloni, E, Lauria, A, Nicola Napoli, Bizzarri, C, Manfrini, S., Collaborators, IMDIAB Group, Pozzilli, P, Strollo, R., Capizzi, M, Daria Maggi, Dario Pitocco, Napoli, N., IMDIAB Group, Schwartz, A, Palermo, A, Fioriti, E, Cappa, M, Tuccinardi, D, Pitocco, D.   +57 more
core   +1 more source

Low total osteocalcin levels are associated with all-cause and cardiovascular mortality among patients with type 2 diabetes: a real-world study

Cardiovascular Diabetology, 2022
Background The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data.
Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao   +9 more
doaj   +1 more source

Serum osteocalcin levels in overweight children [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2019
Purpose Bone plays a role in glucose metabolism through the release of uncarboxylated osteocalcin into the systemic circulation. The identified novel roles for osteocalcin include increasing insulin secretion and sensitivity, energy expenditure ...
Seok Bin Oh, Won Young Lee, Hyo-Kyoung Nam, Young-Jun Rhie, Kee-Hyoung Lee   +4 more
doaj   +1 more source

Effect of fasting versus feeding on the bone metabolic response to running [PDF]

, 2012
Individuals often perform exercise in the fasted state, but the effects on bone metabolism are not currently known. We compared the effect of an overnight fast with feeding a mixed meal on the bone metabolic response to treadmill running. Ten, physically-
Scott, JPR, Casey, Anna, Sale, C, Dutton, John, Greeves, Julie P, Sale, Craig, Scott, Jonathan P R, Greeves, JP, Casey, A, Dutton, J, Fraser, William D, Fraser, WD   +11 more
core   +2 more sources

The Relationship between Serum Osteocalcin Concentration and Glucose Metabolism in Patients with Type 2 Diabetes Mellitus

International Journal of Endocrinology, 2013
To study the correlations between serum osteocalcin and glucose metabolism in patients with type 2 diabetes, 66 cases were collected to determine total osteocalcin, undercarboxylated osteocalcin, fasting blood glucose, fasting insulin, and HbA1c ...
Qingqing Wang, Beibei Zhang, Yulan Xu, Hongdi Xu, Nan Zhang   +4 more
doaj   +1 more source

Effect of carbohydrate feeding on the bone metabolic response to running [PDF]

, 2015
Bone resorption is increased after running, with no change in bone formation. Feeding during exercise might attenuate this increase, preventing associated problems for bone. This study investigated the immediate and short-term bone metabolic responses
Varley, Ian, Sale, C, Greeves, JP, Jones, Thomas W., James, Ruth M., Fraser, WD, Jones, Thomas, James, RM, Tang, Jonathan C. Y., Varley, I, Jones, TW, Tang, JCY, Fraser, William D., Sale, Craig, Greeves, Julie P.   +14 more
core   +1 more source