Results 11 to 20 of about 41,431 (233)
Osteocalcin is necessary and sufficient to maintain muscle mass in older mice
Molecular Metabolism, 2016 Objective: A decrease in muscle protein turnover and therefore in muscle mass is a hallmark of aging. Because the circulating levels of the bone-derived hormone osteocalcin decline steeply during aging in mice, monkeys and humans we asked here whether ...
Paula Mera +4 more
doaj +3 more sources
Osteocalcin: Beyond Bones [PDF]
Endocrinology and MetabolismApart from basic roles such as supporting the body, protecting internal organs, and storing calcium, the skeletal system also performs hormonal functions. In recent years, several reports have been published on proteins secreted by bones and their impact
Jakub Krzysztof Nowicki +1 more
doaj +3 more sources
Effects of 14 days of head-down bed rest with or without exercise, and subsequent recovery on bone turnover, density and structure in older adults. [PDF]
Exp PhysiolAbstract Bed rest accelerates bone loss and may exacerbate skeletal fragility. This study examined the effects of 14 days of head‐down tilt bed rest (HDBR) with or without exercise, and subsequent recovery, on bone turnover, density and structure in older adults. Twenty‐two healthy older adults (55–65 years) completed the HDBR protocol.
Hajj-Boutros G +11 more
europepmc +2 more sources
ZHurnal «Patologicheskaia fiziologiia i eksperimental`naia terapiia», 2020 В качестве общего итога современных биомедицинских исследований стало привычным обнаруживать корреляциенные связи «всего со всем». Четверть вековая история изучения остеокальцина - пример, подтверждающий эту тенденцию. За 25 лет научный статус вещества прогрессировал от белка с неизвестной функцией, просто присутствующего на второй по содержанию ...
openaire +3 more sources
Science-Business eXchange, 2011 Osteocalcin, or bone Gla protein, is a small protein secreted by osteoblasts that can undergo γ-carboxylation. The γ-carboxylated form binds hydroxyapatite and is abundant in bone extracellular matrix. In contrast, the undercarboxylated circulating form has been implicated as a novel hormone and positive regulator of glucose homeostasis.
Kapustin, Alexander N. +1 more
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International Journal of Endocrinology, 2021 Previous studies found that thyroid hormones stimulate osteoblast-like cells to secrete osteocalcin. We aimed to investigate the association between serum thyroid hormone and serum osteocalcin in euthyroid population.
Xiaomin Nie +5 more
doaj +1 more source
Heliyon, 2023 Objective: Basic medical studies have reported an improved effect of osteocalcin on cognition. We explored the causal link between osteocalcin and dementia via the implementation of Mendelian randomization methodology.
Wangmi Liu +4 more
doaj +1 more source
The relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes [PDF]
Zhenduanxue lilun yu shijian, 2021 Objective: To explore the relationship between plasma total testosterone and osteocalcin levels in males with newly diagnosed type 2 diabetes. Methods: A total of 146 males with newly diagnosed type 2 diabetes mellitus admitted from January 2018 through ...
WANG Guangyu, YANG Xin, ZHANG Lijuan, TAN Jiaorong
doaj +1 more source
Frontiers in Physiology, 2022 BackgroundExercise helps improve glucose handling in diabetes and has been shown to improve mood and cognition in other conditions. Osteocalcin, a protein produced by bone osteoblasts, was reported to have endocrine actions to improve both metabolism and
Jordan Winberg +5 more
doaj +1 more source
Bone Reports, 2021 Development of optimal bone mass during early adulthood is determined by the balance between bone formation and resorption. The utility of minimally invasive biomarkers for monitoring bone turnover balance in maturing non-human primates has received ...
Lara H. Sattgast +6 more
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