Results 41 to 50 of about 43,856 (265)

Serum osteocalcin and bone mineral density in postmenopausal women

Universa Medicina, 2016
Since high bone turnover is associated with decreased bone mass, biochemical markers of bone remodeling, such as serum osteocalcin, may be used to assess osteoporosis and to predict fractures in elderly women, particulary those involving trabecular bone,
Lie T. Merijanti Susanto
doaj   +1 more source

Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates

Frontiers in Genetics, 2021
Matrix Gla protein (Mgp) and bone Gla protein (Bgp) are vitamin-K dependent proteins that bind calcium in their γ-carboxylated versions in mammals. They are recognized as positive (Bgp) or negative (Mgp and Bgp) regulators of biomineralization in a ...
Nicolas Leurs, Camille Martinand-Mari, Stéphanie Ventéo, Tatjana Haitina, Mélanie Debiais-Thibaud   +4 more
doaj   +1 more source

Sclerostin and Osteocalcin: Candidate Bone-Produced Hormones

Frontiers in Endocrinology, 2021
In addition to its structural role, the skeleton serves as an endocrine organ that controls mineral metabolism and energy homeostasis. Three major cell types in bone - osteoblasts, osteoclasts, and osteocytes – dynamically form and maintain bone and ...
Jialiang S. Wang, Courtney M. Mazur, Marc N. Wein, Marc N. Wein, Marc N. Wein   +4 more
doaj   +1 more source

THE RELATION BETWEEN TYPES OF IRON CHELATORS AND FERITIN ON OSTEOCALCIN OF THALASSEMIA PATIENTS WITH REPEATED TRANSFUSIONS

Jurnal Kedokteran Diponegoro, 2020
Introduction:  Thalassemia is an inherited disorder that decrease the rate of globin synthesis. Multiple blood transfusions in thalassemia patients leading to complications of hemosiderosis and hemochromatosis. Iron chelator aims to remove excess iron in
Sesa Amelia, Trilaksana Nugroho, Nyoman Suci Widyastiti, Fathur Nur Kholis   +3 more
doaj   +1 more source

A trend of osteocalcin in diabetes mellitus research: bibliometric and visualization analysis

Frontiers in Endocrinology
BackgroundOsteocalcin has attracted attention for its potential role in diabetes management. However, there has been no bibliometric assessment of scientific progress in this field.MethodsWe analysed 1680 articles retrieved from the Web of Science Core ...
Zixu Liu, Zixu Liu, Yuchen Mao, Kangping Yang, Shukai Wang, Fang Zou   +5 more
doaj   +1 more source

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury [PDF]

Asian Spine Journal, 2020
Study Design Prospective observational study. Purpose To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and postmenopausal females. Overview of Literature
Prince Thakkar, Naveen B. Prakash, George Tharion, Sahana Shetty, Thomas V. Paul, Joseph Bondu, Bijesh Yadav   +6 more
doaj   +1 more source

Aqueous Two‐Phase Bioinks for Discrete Packing and Compartmentalization of 3D Bioprinted Cells

Advanced Healthcare Materials, EarlyView.
Aqueous two‐phase systems (ATPS) enable the formation of biomimetic interfaces crucial for tissue engineering. However, clinical translation remains limited by the challenge of precisely controlling cellular compartmentalization. Here, we developed ATPS biomaterial inks for 3D bioprinting allowing tuneable droplet formation via NaCl modulation.
Martina Marcotulli, Arianna Iacomino, Federico Serpe, Lucia Iafrate, Marco Bastioli, Giorgia Montalbano, Michele D'Orazio, Biagio Palmisano, Silvia Franco, Arianna Mencattini, Roberta Angelini, Eugenio Martinelli, Alessandro Corsi, Mara Riminucci, Giancarlo Ruocco, Chiara Scognamiglio, Andrea Barbetta, Gianluca Cidonio   +17 more
wiley   +1 more source

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

eLife, 2020
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai, Catherine Julien, Julie Lacombe, Denis Faubert, Erandi Lira-Navarrete, Yoshiki Narimatsu, Henrik Clausen, Mathieu Ferron   +7 more
doaj   +1 more source

A Fully Human Engineered Bone Niche With Endogenous Osteoclastogenesis Reveals Osteoclast‐Dependent Osteomimicry in Prostate Cancer Cells

Advanced Healthcare Materials, EarlyView.
A human 3D bone niche integrating osteoblasts and osteoclasts enables co‐culture with prostate cancer cell lines and patient‐derived organoids. The engineered niche (i) models aspects of reciprocal phenotypic regulation between osteoblasts and cancer cells, (ii) captures osteoclast‐enhanced osteomimicry in tumor cells, and (iii) establishes a ...
Andrea Mazzoleni, Robin Dolgos, Thomas Menter, Boris Dasen, Arnaud Scherberich, Clémentine Le Magnen, Manuele G. Muraro, Ivan Martin   +7 more
wiley   +1 more source

Endocrine Actions of Osteocalcin

International Journal of Endocrinology, 2013
Osteocalcin is the most abundant noncollagenous protein of bone matrix. Once transcribed, this protein undergoes posttranslational modifications within osteoblastic cells before its secretion, including the carboxylation of three glutamic residues in glutamic acid, which is essential for hydroxyapatite binding and deposition in the extracellular matrix
Patti, A., Gennari, L., Merlotti, D., Dotta, F., Nuti, R.   +4 more
openaire   +5 more sources