Results 61 to 70 of about 79,934 (285)

Evaluating Bone Loss with Bone Turnover Markers Following Acute Spinal Cord Injury [PDF]

Asian Spine Journal, 2020
Study Design Prospective observational study. Purpose To evaluate bone turnover markers (BTMs) in individuals with acute spinal cord injury (SCI) and to compare the results with those of healthy controls and postmenopausal females. Overview of Literature
Prince Thakkar, Naveen B. Prakash, George Tharion, Sahana Shetty, Thomas V. Paul, Joseph Bondu, Bijesh Yadav   +6 more
doaj   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Osteocalcin as a hormone regulating glucose metabolism [PDF]

, 2015
The number of patients with osteoporosis and diabetes is rapidly increasing all over the world. Bone is recently recognized as an endocrine organ. Accumulating evidence has shown that osteocalcin, which is specifically expressed in osteoblasts and ...
Kanazawa, Ippei
core   +1 more source

The half-life of the bone-derived hormone osteocalcin is regulated through O-glycosylation in mice, but not in humans

eLife, 2020
Osteocalcin (OCN) is an osteoblast-derived hormone with pleiotropic physiological functions. Like many peptide hormones, OCN is subjected to post-translational modifications (PTMs) which control its activity.
Omar Al Rifai, Catherine Julien, Julie Lacombe, Denis Faubert, Erandi Lira-Navarrete, Yoshiki Narimatsu, Henrik Clausen, Mathieu Ferron   +7 more
doaj   +1 more source

Micro‐Galvanic Coupling Programs the Therapeutic Zinc Ion Window to Reconfigure Immune Cascades for Pro‐Regenerative Bone Healing

Advanced Science, EarlyView.
This study utilized alloy micro‐galvanic coupling design to regulate the release of essential elements, thereby programming immune responses and promoting regeneration. The sacrificial anodic process of Zn‐0.8Mg reduced Zn2+ release compared to the “large cathode‐small anode” coupling of Zn‐0.8Fe.
Chaoyang Sun, Bo Jia, Jiahui Shi, Shuang Li, Guo Bao, Dong Bian, Kai Chen, Junlong Tan, Xuenan Gu, Yan Guan, Yu Qin, Xinhua Qu, Xiaogang Wang, Yufeng Zheng, Hongtao Yang   +14 more
wiley   +1 more source

Osteocalcin expression in cells : recent research in dentistry [PDF]

, 2012
Alveolar bone is one of the most active areas of bone remodeling in the body. Bone remodeling is one of the hot topics of research in dentistry because teeth are embedded in bone.
Li, XT, Zhang, D, Li, Xiaotong, Rabie, ABM, Chai, Lei, Zhang, Ding, Yang, Y, Chai, L, Yang, Yanqi   +8 more
core  

Association of osteocalcin polymorphisms with serum osteocalcin levels (median ± IQR, ng/mL) in cases and healthy controls. [PDF]

, 2015
CHB chronic hepatitis B, HCC hepatocellular carcinoma,LC liver cirrhosis,IQR interquartile range, OC, osteocalcin, N group number* Kruskal-Wallis test: comparing the difference of serum osteocalcin levels in the three genotypes among the same group ...
Xiamei Huang (683601), Yanqiong Liu (640974), Xiu-Li Huang (448786), Xue Qin (123365), Qinghua Lu (683600), Yu Lu (11575), Xue-E Xi (683599), Liying Huang (366417), Shan Li (110392)   +8 more
core   +1 more source

Roles for osteocalcin in brain signalling: implications in cognition- and motor-related disorders

Molecular Brain, 2019
It is now generally accepted that the extra-skeleton functionalities of bone are multifaceted. Its endocrine functions came first to light when it was realized that osteoblasts, the bone forming cells, maintain energy homeostasis by improving glucose ...
Chang Shan, Arijit Ghosh, Xing-zhi Guo, Shu-min Wang, Yan-fang Hou, Sheng-tian Li, Jian-min Liu   +6 more
semanticscholar   +1 more source

Unraveling Bone‐Skin Crosstalk Enables miRNA Nanoformulation for Cutaneous Neurovascular Reconstruction in Diabetic Mice

Advanced Science, EarlyView.
This study unravels that bone fracture accelerates diabetic wound healing by releasing exosomal microRNA (miR‐130b‐3p). To mimic this bone‐skin crosstalk, we engineered a self‐assembling agomir‐130b‐3p nanocomplex. Delivered via a photocrosslinkable hydrogel, this bio‐inspired therapy provides sustained localized agomir release.
Tao Shen, Hongdou Shen, Weiyue Wu, Zhuoying Jiang, Bin Liu, Yansi Xian, Rui Peng, An Yan, Yu Ben, Yong Shi, Xiang Chen, Baosheng Guo, Qing Jiang, Weijun Wang, Pingqiang Cai   +14 more
wiley   +1 more source

YAP1‐Driven Pathogenic Fibro‐Adipogenic Progenitors Secrete IL‐6 and FGF21 to Mediate Muscle‐Bone Crosstalk and Promote Bone Loss

Advanced Science, EarlyView.
Fibro‐adipogenic progenitors (FAPs) in atrophic muscle undergo YAP1‐driven pathogenic activation, secreting IL‐6 and FGF21 as bone‐catabolic myokines that mediate muscle‐bone crosstalk and promote bone loss. Genetic or pharmacological targeting of this YAP1‐FAP‐myokine axis rescues skeletal deterioration, identifying FAP‐derived myokines as therapeutic
Xiaoyu Cai, Tao Xu, Rui Ma, Weikun Meng, Shutao Gao, Yakefu Abulizi, Alafate Kahaer, Chuanhui Xun, Maierdan Maimaiti, Rui Cao, Weidong Liang, Polati Maimaiti, Qiang Deng, Jun Sheng, Ting Wang, Mingchong Liu, Weibin Sheng   +16 more
wiley   +1 more source