Osteocalcin Regulates Arterial Calcification Via Altered Wnt Signaling and Glucose Metabolism
Journal of Bone and Mineral Research, 2019 Arterial calcification is an important hallmark of cardiovascular disease and shares many similarities with skeletal mineralization. The bone‐specific protein osteocalcin (OCN) is an established marker of vascular smooth muscle cell (VSMC ...
Nabil A. Rashdan +14 more
semanticscholar +1 more source
Osteocalcin in the brain: from embryonic development to age-related decline in cognition
Nature Reviews Endocrinology, 2018 A remarkable, unexpected aspect of the bone-derived hormone osteocalcin is that it is necessary for both brain development and brain function in the mouse, as its absence results in a profound deficit in spatial learning and memory and an exacerbation of
A. Obri +3 more
semanticscholar +1 more source
Evolution of Matrix Gla and Bone Gla Protein Genes in Jawed Vertebrates
Frontiers in Genetics, 2021 Matrix Gla protein (Mgp) and bone Gla protein (Bgp) are vitamin-K dependent proteins that bind calcium in their γ-carboxylated versions in mammals. They are recognized as positive (Bgp) or negative (Mgp and Bgp) regulators of biomineralization in a ...
Nicolas Leurs +4 more
doaj +1 more source
Table_1_Glucose Tolerance Tests and Osteocalcin Responses in Healthy People.DOCX [PDF]
, 2018 Aim: Osteocalcin and undercarboxylated osteocalcin are suggested to be endocrine messengers from the bones and have been shown to stimulate insulin secretion from pancreatic β-cells.
Aase Handberg (458084) +8 more
core +1 more source
Osteocalcin signaling in myofibers is necessary and sufficient for optimum adaptation to exercise
Cell Metabolism, 2016 Summary Circulating levels of undercarboxylated and bioactive osteocalcin double during aerobic exercise at the time those of insulin decrease. In contrast, circulating levels of osteocalcin plummet early during adulthood in mice, monkeys and humans of ...
Paula Mera +19 more
semanticscholar +1 more source
Osteocalcin and Parental Perceptions. Childhood osteocalcin and its association to early growth, body composition and neurodevelopment along with parental perceptions on childhood overweight and obesity [PDF]
Background and aims: Early programming mean that environmental factors, hormonal levels and early life experiences, like feeding practices, during the first years of life, may have long-lasting effects on later health.
Berggren, Sara
core +1 more source
Endocrine Actions of Osteocalcin [PDF]
, 2013 Osteocalcin is the most abundant noncollagenous protein of bone matrix. Once transcribed, this protein undergoes posttranslational modifications within osteoblastic cells before its secretion, including the carboxylation of three glutamic residues in ...
Luigi Gennari +9 more
core +2 more sources
Jurnal Kedokteran Diponegoro, 2020 Introduction: Thalassemia is an inherited disorder that decrease the rate of globin synthesis. Multiple blood transfusions in thalassemia patients leading to complications of hemosiderosis and hemochromatosis. Iron chelator aims to remove excess iron in
Sesa Amelia +3 more
doaj +1 more source
Cbfa-1 (Runx-2) and osteocalcin expression by human osteoblasts in heparin osteoporosis in vitro [PDF]
, 2006 Heparin may cause adverse effects on bone formation following long-term application. The exact pathomechanism is unclear, but in vitro data suggest an impaired osteoblast function.
Wanner, Guido A +6 more
core +1 more source
A trend of osteocalcin in diabetes mellitus research: bibliometric and visualization analysis
Frontiers in EndocrinologyBackgroundOsteocalcin has attracted attention for its potential role in diabetes management. However, there has been no bibliometric assessment of scientific progress in this field.MethodsWe analysed 1680 articles retrieved from the Web of Science Core ...
Zixu Liu +5 more
doaj +1 more source