Results 71 to 80 of about 79,934 (285)

Bone Remodeling Regulators in Central Giant Cell Granuloma: a Study of RANK and Osteocalcin Expression [PDF]

Background: Giant cell granulomas of the jaws are reactive bone lesions that impact bone remodeling. The specific pathophysiology was unclear, although osteoclast-type giant and stromal cells were suggested as major modulating factors.
Jawaher M TAHER, Karrar N. SHAREEF, Zinah A. HAMDALA, Noor Natik RAHEEM   +3 more
core   +1 more source

Osteocalcin of maternal and embryonic origins synergize to establish homeostasis in offspring

EMBO Reports
Many physiological osteocalcin-regulated functions are affected in adult offspring of mothers experiencing unhealthy pregnancy. Furthermore, osteocalcin signaling during gestation influences cognition and adrenal steroidogenesis in adult mice.
Danilo Correa Pinto Junior, Isabella Canal Delgado, Haiyang Yang, Alisson Clemenceau, André Corvelo, Giuseppe Narzisi, Rajeeva Musunuri, Julian Meyer Berger, Lauren E Hendricks, Kazuya Tokumura, Na Luo, Hongchao Li, Franck Oury, Patricia Ducy, Vijay K Yadav, Xiang Li, Gerard Karsenty   +16 more
doaj   +1 more source

Engineered Xenogeneic Bone Scaffold with IL‐10 Nanodelivery System: Immunomodulation and BMSC Fate Programming for Skull Defect Repair

Advanced Science, EarlyView.
A multifunctional regenerative composite is constructed by 3D‐printing thermosensitive PNIPAM hydrogel embedded with MPDA@IL‐10 nanoparticles and autologous BMSCs onto antigen‐depleted porcine bone matrix for beagle critical‐sized skull defect reconstruction.
Weihao Lv, Lei Zhang, Fei Fei, Zhibin Wu, Xiuquan Wu, Ya‐nan Dou, Yihao Fu, Hao Chang, Yujie Qiang, Huaxia Xie, Ni An, Leiying Chen, Hongchen Zhang, Min‐Wen Zheng, Hongqing Chen, Xia Li, Zhou Fei   +16 more
wiley   +1 more source

Osteocalcin and osteopontin influence bone morphology and mechanical properties

Annals of the New York Academy of Sciences, 2017
Osteocalcin (OC) and osteopontin (OPN) are major non‐collagenous proteins (NCPs) involved in bone matrix organization and deposition. In spite of this, it is currently unknown whether OC and OPN alter bone morphology and consequently affect bone fracture
S. Bailey, G. Karsenty, C. Gundberg, D. Vashishth   +3 more
semanticscholar   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

Advanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao, Qiuyi Li, Lingyun Wang, Chongao Zhang, Yutian Cheng, Shuang Liu, Fulan Wei, Zheqin Dong   +7 more
wiley   +1 more source

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Osteocalcin Affects Bone Mineral and Mechanical Properties in Female Mice.

Bone, 2019
Osteocalcin is one of the most abundant noncollagenous proteins in bone. Phenotypes of osteocalcin knock-out mice (OC-/-) may vary on different backgrounds and with sex.
O. Berezovska, G. Yıldırım, W. Budell, S. Yagerman, B. Pidhaynyy, C. Bastien, M. V. D. Meulen, M. V. D. Meulen, Terry L. Dowd, Terry L. Dowd   +9 more
semanticscholar   +1 more source

Porous Poly(ε‐Caprolactone)/Keratin Composite Scaffolds: Structural Features, Degradation Behavior and Cell‐Material Interactions

Journal of Applied Polymer Science, EarlyView.
ABSTRACT Porous scaffolds based on pure poly(ε‐caprolactone) (PCL) and on biocomposite made of PCL and feather‐extracted β‐keratin (FK) were fabricated by salt‐leaching method. FK was incorporated into PCL to address the limited bioactivity and hydrophobic nature of PCL, with the aim of improving cell–material interactions for bone tissue engineering ...
Gianluca Rinaldi, Nancy Ferrentino, Martina Mucciolo, Valentina Sessini, Marina Paolucci, Elena Coccia, Daniela Pappalardo   +6 more
wiley   +1 more source

Association between serum osteocalcin level and blood pressure in a Chinese population

Blood Pressure, 2018
Purpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population. Materials and methods: A total of 2241 subjects (909 men and 1,332 women; age, 24–78 years) from Shanghai ...
Yiting Xu, Xiaojing Ma, Qin Xiong, Xiang Hu, Xueli Zhang, Yeqing Yuan, Yuqian Bao   +6 more
doaj   +1 more source

First evidence of octacalcium phosphate@osteocalcin nanocomplex as skeletal bone component directing collagen triple–helix nanofibril mineralization

Scientific Reports, 2018
Tibia trabeculae and vertebrae of rats as well as human femur were investigated by high-resolution TEM at the atomic scale in order to reveal snapshots of the morphogenetic processes of local bone ultrastructure formation.
P. Simon, D. Grüner, H. Worch, W. Pompe, H. Lichte, T. El Khassawna, C. Heiss, S. Wenisch, R. Kniep   +8 more
semanticscholar   +1 more source