Results 91 to 100 of about 12,470,437 (381)

Quinidine in Treatment of Migrating Partial Seizures of Infancy

Pediatric Neurology Briefs, 2014
Investigators at Children's Hospital of Philadelphia, PA, report a 3-year-old female who had presented with seizures at 10 weeks of life.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Deep Neural Network with l2-norm Unit for Brain Lesions Detection

, 2017
Automated brain lesions detection is an important and very challenging clinical diagnostic task because the lesions have different sizes, shapes, contrasts, and locations.
B Menze, C Gulcehre, J Uijlings, M Havaei, O Ronneberger, Y LeCun   +5 more
core   +1 more source

Hepatic acute phase response protects the brain from focal inflammation during postnatal window of susceptibility [PDF]

, 2018
Perinatal inflammation is known to contribute to neurodevelopmental diseases. Animal models of perinatal inflammation have revealed that the inflammatory response within the brain is age dependent, but the regulators of this variation remain unclear.
Anthony, D C, Consentino Kronka Sosthenes, M, Couch, Y, Evans, M C, Roodselaar, J, Stolp, H B, Sá-Pereira, I   +6 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Identification of the clinical and genetic characteristics of gliomas with gene fusions by integrated genomic and transcriptomic analysis

European Journal of Medical Research
The identification of oncogenic gene fusions in diffuse gliomas may serve as potential therapeutic targets and prognostic indicators, representing a novel strategy for treating gliomas consistent with the principles of personalized medicine.
Guo-zhong Yi, Hua-yang Zhang, Tian-shi Que, Shan-qiang Qu, Zhi-yong Li, Song-tao Qi, Wen-yan Feng, Guang-long Huang   +7 more
doaj   +1 more source

Music Affinity in Wolf-Hirschhorn Syndrome

Pediatric Neurology Briefs, 2014
Investigators at Nihon University School of Medicine, Tokyo, Japan, report two patients with Wolf-Hirschhorn syndrome (WHS) who have a strong affinity for music, not previously described as a feature of this syndrome.
J Gordon Millichap, John J Millichap
doaj   +1 more source

24S‐hydroxycholesterol: Cellular effects and variations in brain diseases

Journal of Neurochemistry, 2020
The adult brain exhibits a characteristic cholesterol homeostasis, with low synthesis rate and active catabolism. Brain cholesterol turnover is possible thanks to the action of the enzyme cytochrome P450 46A1 (CYP46A1) or 24‐cholesterol hydroxylase, that
A. Sodero
semanticscholar   +1 more source

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

AAP Genetics Diagnostic Approach to Intellectual Disability or Global Developmental Delay

Pediatric Neurology Briefs, 2014
The American Academy of Pediatrics Committee on Genetics present a recommended clinical genetics diagnostic approach to the evaluation of intellectual disability or global developmental delays.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Pediatric Neurology Briefs: Year in Review

Pediatric Neurology Briefs, 2020
In 2020, the mission of Pediatric Neurology Briefs (PNB) remains the same: “PNB is a continuing education service designed to expedite and facilitate the review of current scientific research and advances in child neurology and related subjects.”
John J Millichap
doaj   +1 more source