Results 231 to 240 of about 1,930,566 (331)

Purkinje Cell Loss in Essential Tremor: Collective Data From 215 Brains Over a 21‐Year Period

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Essential tremor is a highly prevalent movement disorder. Pathological changes observed in essential tremor cerebella center around Purkinje cells and neighboring neuronal populations. Postmortem studies have variably, but not always, shown reduced Purkinje cell counts in essential tremor compared to controls.
Chloë A. Kerridge, Roberto S. Hernandez, Nora C. Hernandez, Phyllis L. Faust, Elan D. Louis   +4 more
wiley   +1 more source

tRNA Modifications and Dysregulation: Implications for Brain Diseases. [PDF]

Brain Sci
Lv X, Zhang R, Li S, Jin X.
europepmc   +1 more source

Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegias (HSP) are rare neurodegenerative disorders marked by spasticity and lower limb weakness. The most common type, SPG4, is usually autosomal dominant and caused by SPAST gene variants, typically presenting as pure HSP.
Gregorio A. Nolasco, Mònica Roldán, Yalda Jamshidi, Ioannis Georvasilis, Rocío Jadraque Rodríguez, Reza Boostani, Ali Shoeibi, Lluís Armengol, Anna Codina, Ehsan Ghayoor Karimiani, Cristina Hernando‐Davalillo, Loreto Martorell, María Luisa Ramírez Almaraz, Jordi Muchart, Carlos Ortez, Andrés Nascimento, Roser Urreizti, Daniel Natera‐de Benito, Mercedes Serrano   +18 more
wiley   +1 more source

Identifying the quality markers and optimizing the processing of Gastrodiae rhizoma to treat brain diseases. [PDF]

Front Pharmacol
Fu Y, Xu Q, Zhang J, Kang C, Yang C, Guo L, Zhang C, Zhou T, Xiao C.   +8 more
europepmc   +1 more source

Fatty acid composition of brain glycolipids in Alzheimer's disease, senile dementia, and cerebrocortical atrophy

, 1968
George D. Cherayil
openalex   +1 more source

Brain dopamine metabolism in patients with Parkinson's disease measured with positron emission tomography. [PDF]

, 1986
Klaus L. Leenders, Andrew Palmer, Niall Quinn, Clark Jb, G. Firnau, E.S. Garnett, Claude Nahmias, Terry Jones, C. D. Marsden   +8 more
openalex   +1 more source

Annual 12‐Week Dosing Gap of Natalizumab: Clinical Efficacy, Blood Biomarkers, and CSF Cell Composition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Natalizumab (NTZ) is a highly effective therapy for multiple sclerosis (MS); however, its use is limited by the risk of a rare potentially severe opportunistic brain infection, progressive multifocal leukoencephalopathy (PML). Alternative dosing strategies are evaluated to reduce PML risk while still maintaining efficacy, which ...
Regina Berkovich, Tilman Schneider‐Hohendorf, Eric Baetscher, Evan L. Riddle, Marie Deffner, Emily Katsnelson, Janine Ferrant‐Orgettas, Julie Czerkowicz, John Anderson, Susan E. Goelz, Nicholas Schwab   +10 more
wiley   +1 more source

Explainable Machine Learning Models for Brain Diseases: Insights from a Systematic Review. [PDF]

Neurol Int
Rodríguez Mallma MJ, Zuloaga-Rotta L, Borja-Rosales R, Rodríguez Mallma JR, Vilca-Aguilar M, Salas-Ojeda M, Mauricio D.   +6 more
europepmc   +1 more source

1657 MAGNETIC RESONANCE (MR) BRAIN IMAGING IN GENETIC METABOLIC DISEASES: DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS [PDF]

, 1985
Richard J. Allen, S S Gebarski, Alex M. Aisen   +2 more
openalex   +1 more source

Exosome Proteomics of SOD1D90A Mutation Suggest Early Disease Mechanisms, and FN1 as a Biomarker

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Amyotrophic lateral sclerosis (ALS) is a neuromuscular disease. Super oxide dismutase 1 (SOD1) gene mutations cause ALS, and the D90A mutation is associated with primarily upper motor neuron (UMN) loss. Objective Our goal is to reveal the early cellular events in ALS pathology and identify potential pharmacokinetic biomarkers, using well ...
Mukesh Gautam, Ali Laith, Aslihan Gunel, Melda Yilmaz, Nazli Basak, Halil Idrisoglu, P. Hande Ozdinler   +6 more
wiley   +1 more source