Results 71 to 80 of about 12,470,437 (381)

Brain MRI in Parkinson's disease [PDF]

Frontiers in Bioscience, 2014
In this review article, conventional brain MRI and advanced MRI techniques in Parkinson`s disease (PD) are discussed, with emphasis on clinical relevance. Conventional brain MRI sequences generally demonstrate limited abnormalities specific for PD and in clinical practice brain MRI is mainly used to exclude other pathology.
Meijer, F.J.A., Meijer, F.J.A., Goraj, B.M., Goraj, B.M.   +3 more
openaire   +3 more sources

Inflammasomes in neuroinflammatory and neurodegenerative diseases [PDF]

, 2019
Neuroinflammation and neurodegeneration often result from the aberrant deposition of aggregated host proteins, including amyloid-beta, alpha-synuclein, and prions, that can activate inflammasomes.
Lamkanfi, Mohamed, Srinivasan, Sahana, van Loo, Geert, Voet, Sofie   +3 more
core   +2 more sources

Microbiota–gut–brain axis and its therapeutic applications in neurodegenerative diseases

Signal Transduction and Targeted Therapy
The human gastrointestinal tract is populated with a diverse microbial community. The vast genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every aspect of human biology, including health maintenance, development ...
Jian Sheng Loh, Wen Qi Mak, Lily Tan, Chu Xin Ng, Hong Hao Chan, Shiau Hueh Yeow, J. Foo, Y. Ong, C. W. How, K. Khaw   +9 more
semanticscholar   +1 more source

Artificial intelligence for brain diseases: A systematic review

APL Bioengineering, 2020
Artificial intelligence (AI) is a major branch of computer science that is fruitfully used for analyzing complex medical data and extracting meaningful relationships in datasets, for several clinical aims.
Alice Segato, A. Marzullo, Francesco Calimeri, E. De Momi   +3 more
semanticscholar   +1 more source

CaMKIIβ in Neuronal Development and Plasticity: An Emerging Candidate in Brain Diseases

International Journal of Molecular Sciences, 2020
The calcium/calmodulin-dependent protein kinase II (CaMKII) is a ubiquitous and central player in Ca2+ signaling that is best known for its functions in the brain. In particular, the α isoform of CaMKII has been the subject of intense research and it has
O. Nicole, E. Pacary
semanticscholar   +1 more source

Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella

Scientific Reports
Shigellosis remains a common gastrointestinal disease mostly in children 
Asaduzzaman Asad, Israt Jahan, Moriam Akter Munni, Ruma Begum, Morium Akter Mukta, Kazi Saif, Shah Nayeem Faruque, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Microglia-derived microvesicles affect microglia phenotype in glioma [PDF]

, 2019
Extracellular-released vesicles (EVs), such as microvesicles (MV) and exosomes (Exo) provide a new type of inter-cellular communication, directly transferring a ready to use box of information, consisting of proteins, lipids and nucleic acids.
Alfonso Grimaldi, Angelo Sarra, Barbara Ruzicka, Carmela Serpe, Cristina Limatola, Cristina Limatola, Francesca Guerrieri, Giancarlo Ruocco, Giuseppe Familiari, Giuseppe Rubens Pascucci, Giuseppina Chece, Michela Relucenti, Myriam Catalano, Myriam Catalano, Valentina Nigro   +14 more
core   +5 more sources

Targeting with nanoparticles for the therapeutic treatment of brain diseases

Journal of Tissue Engineering, 2020
Brain diseases including neurodegenerative disorders and tumours are among the most serious health problems, degrading the quality of life and causing massive economic cost.
G. jin, A. Chakraborty, Jung-Hwan Lee, J. Knowles, H. Kim   +4 more
semanticscholar   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Phagocytosis in the Brain: Homeostasis and Disease [PDF]

Frontiers in Immunology, 2019
Microglia are resident macrophages of the central nervous system and significantly contribute to overall brain function by participating in phagocytosis during development, homeostasis, and diseased states. Phagocytosis is a highly complex process that is specialized for the uptake and removal of opsonized and non-opsonized targets, such as pathogens ...
Galloway, DA, Phillips, AEM, Owen, D, Moore, CS   +3 more
openaire   +6 more sources