Results 51 to 60 of about 4,808,098 (303)

Genomic loci influence patterns of structural covariance in the human brain [PDF]

, 2023
Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases.
Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER)
core  

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Nanozymes Regulate Redox Homeostasis in ROS-Related Inflammation

Frontiers in Chemistry, 2021
Reactive oxygen species (ROS), in moderate amounts, play an essential role in regulating different physiological functions in organisms. However, increased amounts of ROS may cause oxidative stress and damage to biomolecules, leading to a variety of ...
Qing Li, Qing Li, Ying Liu, Ying Liu, Xianglin Dai, Xianglin Dai, Wei Jiang, Wei Jiang, Huan Zhao   +8 more
doaj   +1 more source

Pheochromocytoma with Brain Metastasis: A Extremely Rare Case in Worldwide. [PDF]

, 2018
Pheochromocytoma (PCC) is a neuroendocrine tumor that mainly arises from the medulla of the adrenal gland. Some PCCs become malignant and metastasize to other organs.
조윤성, 김세훈, 강석구
core   +1 more source

Recent Update on Neurosurgical Management of Brain Metastasis [PDF]

, 2022
Brain metastasis (BM), classified as a secondary brain tumor, is the most common malignant central nervous system tumor whose median overall survival is approximately 6 months.
박현호, 장종희, 강석구, 유지환   +3 more
core   +1 more source

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Genotype-Phenotype Correlations and Functional Outcomes in Pediatric Patients with KCNQ2-Related Epilepsy: A Multicenter Observational Study in Korea [PDF]

Annals of Child Neurology
Purpose Potassium voltage-gated channel subfamily Q member 2 (KCNQ2)-related epilepsy, caused by mutations in the KCNQ2 gene, encompasses a spectrum of epileptic phenotypes, ranging from self-limited epilepsy to severe developmental and epileptic ...
Eon Ah Kim, Mi-Sun Yum, Seungbok Lee, Jae So Cho, Jeehun Lee, Byung Chan Lim   +5 more
doaj   +1 more source

Emerging roles of TRIM27 in cancer and other human diseases

Frontiers in Cell and Developmental Biology, 2022
As a member of the TRIM protein family, TRIM27 is a RING-mediated E3 ubiquitin ligase that can mark other proteins for degradation. Its ubiquitination targets include PTEN, IκBα and p53, which allows it to regulate many signaling pathways to exert its ...
Chengpeng Yu, Chengpeng Yu, Dean Rao, Dean Rao, Tiantian Wang, Tiantian Wang, Jia Song, Jia Song, Lei Zhang, Lei Zhang, Lei Zhang, Wenjie Huang, Wenjie Huang   +12 more
doaj   +1 more source

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG   +30 more
core   +1 more source

Neuropsychological and Educational Outcomes in Shwachman–Diamond Syndrome—A Report From the North American Shwachman–Diamond Syndrome Registry

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Shwachman–Diamond syndrome (SDS) is a rare autosomal recessive ribosomopathy characterized by bone marrow failure and multisystem involvement, with emerging evidence of associated neurocognitive impairment. Methods We conducted a retrospective study of 240 individuals with biallelic Shwachman–Bodian–Diamond syndrome (SBDS) mutations
Jane Koo, Melissa Gerstle, Leah Cheng, Richard Cooper, Katherine Coyne, Claire Dusa, Naomi E. Joffe, Diana Schwarz, Sarah Steltz, Akiko Shimamura, Kasiani C. Myers, Thea Quinton   +11 more
wiley   +1 more source