Results 41 to 50 of about 4,808,098 (303)

Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases

, 2023
This chapter utilizes genomic concepts and evolutionary perspectives to further understand the possible links between typical brain aging and neurodegenerative diseases, focusing on the two most prevalent of these: Alzheimer's disease and Parkinson's ...
Rigby Dames, B.A, Kilili, H, Urrutia, A.O, Proulx, M.J, de Sousa, A.A, Díaz-Barba, K, Charvet, C.J   +6 more
core   +3 more sources

Cognitive Outcome of Childhood-Onset Multiple Sclerosis Patients

Pediatric Neurology Briefs, 2014
Investigators on behalf of the MS Study Group of the Italian Neurological Society performed a third cognitive assessment on 48 of 63 patients with childhood or juvenile MS in the original cohort and compared with 46 healthy controls.
J Gordon Millichap, John J Millichap
doaj   +1 more source

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model [PDF]

, 2012
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases.
Tikva Vogel, Zensi, Anja, von Briesen Hagen, Kreuter Jörg, Worek Franz, Tschickardt, Sabrina E., Sascha L Wien, Jörg Kreuter, Wien Sascha L., Vogel Tikva, Sabrina E Tschickardt, Wladislaw Maier, Vogel, Tikva, Sylvia Wagner, Claus U Pietrzik, Maier Wladislaw, Zensi Anja, Wien, Sascha L., Maier, Wladislaw, Tschickardt Sabrina E., Wagner, Sylvia, Pietrzik Claus U., Anja Zensi, Kreuter, Jörg, Worek, Franz, Hagen von Briesen, Pietrzik, Claus Ulrich, Briesen, Hagen von, Wagner Sylvia, Franz Worek   +29 more
core   +2 more sources

Clostridioides difficile and neurological disorders: New perspectives

Frontiers in Neuroscience, 2022
Despite brain physiological functions or pathological dysfunctions relying on the activity of neuronal/non-neuronal populations, over the last decades a plethora of evidence unraveled the essential contribution of the microbial populations living and ...
Manuele Biazzo, Manuele Biazzo, Manuela Allegra, Gabriele Deidda   +3 more
doaj   +1 more source

Susceptibility-Weighted Imaging (SWI): Technical Aspects and Applications in Brain MRI for Neurodegenerative Disorders

Bioengineering
Susceptibility-weighted imaging (SWI) is a magnetic resonance imaging (MRI) sequence sensitive to substances that alter the local magnetic field, such as calcium and iron, allowing phase information to distinguish between them.
Federica Vaccarino, Carlo Cosimo Quattrocchi, Marco Parillo   +2 more
doaj   +1 more source

AsKC11, a Kunitz Peptide from Anemonia sulcata, Is a Novel Activator of G Protein-Coupled Inward-Rectifier Potassium Channels

Marine Drugs, 2022
(1) Background: G protein-coupled inward-rectifier potassium (GIRK) channels, especially neuronal GIRK1/2 channels, have been the focus of intense research interest for developing drugs against brain diseases.
Dongchen An, Ernesto Lopes Pinheiro-Junior, László Béress, Irina Gladkikh, Elena Leychenko, Eivind A. B. Undheim, Steve Peigneur, Jan Tytgat   +7 more
doaj   +1 more source

Amyloid tracers detect multple binding sites in Alzheimer´s disease brain tissue. [PDF]

, 2013
Imaging fibrillar amyloid-β deposition in the human brain in vivo by positron emission tomography has improved our understanding of the time course of amyloid-β pathology in Alzheimer’s disease. The most widely used amyloid-β imaging tracer so far is 11C-
Nordberg, A,, Ni, Ruiqing, Marutle, Amelia, Gillberg, P-G, Marutle, A,, Bergfors, A, Nordberg, Agneta, Gillberg, Per-Göran, Bergfors, Assar, Ni, R,   +9 more
core   +1 more source

Multidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella

Scientific Reports
Shigellosis remains a common gastrointestinal disease mostly in children 
Asaduzzaman Asad, Israt Jahan, Moriam Akter Munni, Ruma Begum, Morium Akter Mukta, Kazi Saif, Shah Nayeem Faruque, Shoma Hayat, Zhahirul Islam   +8 more
doaj   +1 more source

Revisiting intra-arterial drug delivery for treating brain diseases or is it “déjà-vu, all over again”?

Journal of Neuroanaesthesiology and Critical Care, 2014
For over six decades intra-arterial (IA) drugs have been sporadically used for the treatment of lethal brain diseases. In recent years considerable advance has been made in the IA treatment of retinoblastomas, liver and locally invasive breast cancers ...
Shailendra Joshi, Jason A. Ellis, Charles W. Emala   +2 more
doaj   +1 more source

Current status and prospect of endoscopic skull base surgery

Chinese Journal of Contemporary Neurology and Neurosurgery, 2021
Neuroendoscopic techniques, with their good momentum of development and constantly emerging hot spots, have become one of the major aspects of minimally invasive neurosurgery.
ZHANG Xiao⁃biao, SUN Chong⁃jing
doaj   +1 more source