Results 21 to 30 of about 1,182,956 (263)

The microbiome-gut-brain axis in acute and chronic brain diseases [PDF]

, 2020
The gut microbiome — the largest reservoir of microorganisms of the human body — is emerging as an important player in neurodevelopment and ageing as well as in brain diseases including stroke, Alzheimer’s disease and Parkinson’s disease.
Martin-Gallausiaux, C., Benakis, C., Melton, P., Trezzi, J. P., Wilmes, P., Liesz, Arthur   +5 more
core   +1 more source

Genomic loci influence patterns of structural covariance in the human brain [PDF]

, 2023
Normal and pathologic neurobiological processes influence brain morphology in coordinated ways that give rise to patterns of structural covariance (PSC) across brain regions and individuals during brain aging and diseases.
Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, the Netherlands (GJB, GJER)
core  

Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain [PDF]

, 2010
Background and purpose: T‐cells may play a role in the evolution of ischaemic damage and repair, but the ability to image these cells in the living brain after a stroke has been limited.
Brewer JM, De Simoni, M.G., Millington OR, Rodolico G, Bushell, T.J., Dever G, Dever, G., Brewer, J.M., Bushell, T., Ortolano, F., Maffia, P., Millington, O.R., Ortolano F, Rodolico, G., Carswell H.V., Garside P, Garside, P., Carswell, H.V., Maffia, Pasquale, De Simoni MG, Bushell TJ, Carswell, H.V.O.   +21 more
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Glia: the fulcrum of brain diseases [PDF]

Cell Death & Differentiation, 2007
Neuroglia represented by astrocytes, oligodendrocytes and microglial cells provide for numerous vital functions. Glial cells shape the micro-architecture of the brain matter; they are involved in information transfer by virtue of numerous plasmalemmal receptors and channels; they receive synaptic inputs; they are able to release 'glio'transmitters and ...
Giaume, C., Kirchhoff, F., Matute, C., Reichenbach, A., Verkhratsky, A.; id_orcid 0000-0003-2592-9898   +4 more
openaire   +3 more sources

Mixed Brain Pathologies in Dementia: The BrainNet Europe Consortium Experience [PDF]

, 2008
Background: Dementia results from heterogeneous diseases of the brain. Mixed disease forms are increasingly recognized. Methods: We performed a survey within brain banks of BrainNet Europe to estimate the proportion of mixed disease forms underlying ...
Gelpi, Ellen, Kretzschmar H, Alafuzoff, Irina, Alafuzoff I, Budka H., Nagy, Zoltan, Seilhean, Danielle, Ferrer I, Arzberger, Thomas, Al-Sarraj, Safa, Gelpi E, Kovacs, Gabor G., Kretzschmar, Hans, Soininen, Hilkka, Troakes, Claire, Nagy Z, Capellari, Sabina, Seilhean D, Kövari V, Budka, Herbert, Al Sarraj S, Troakes C, Alafuzoff, Irina,, Arzberger T, Ferrer, Isidro, Bogdanovic, Nenad, Bogdanovic N, Kovari, Viktor, Soininen H, Parchi, Piero, Kovacs GG   +30 more
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Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases [PDF]

, 2019
Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to ...
Ling, King Hwa, Mohamed, Farahidah, Mansor, Nur Izzati, Rosli, Rozita, Nordin, Norshariza, Ling, King-Hwa, Hassan, Zurina   +6 more
core   +1 more source

Wnt activation of immortalized brain endothelial cells as a tool for generating a standardized model of the blood brain barrier in vitro [PDF]

, 2013
Reproducing the characteristics and the functional responses of the blood–brain barrier (BBB) in vitro represents an important task for the research community, and would be a critical biotechnological breakthrough.
Eleanna Papa (441409), Rudini, Noemi, B. Engelhardt, Papa, Eleanna, E. Papa, M. Corada, Kavi Devraj, Pierre Olivier Couraud (383879), Couraud, Pierre Olivier, Luca Ferrarini, Monica Corada, Roberta Paolinelli, Pierre Olivier Couraud, K. Devraj, Luigi Maddaluno (441408), Cathrin J Czupalla, Engelhardt, Britta, Britta Engelhardt, Stefan Liebner (307398), R. Paolinelli, Noemi Rudini (441407), C. J. Czupalla, Cédric Artus, Luca Ferrarini (441403), E. Dejana, Elisabetta Dejana, C. Artus, Roberta Paolinelli (237864), Ferrarini, Luca, Devraj, Kavi, Dejana, Elisabetta, N. Rudini, Elisabetta Dejana (110746), Paolinelli, Roberta, Liebner, Stefan, Noemi Rudini, Monica Corada (217515), Cathrin J. Czupalla (441406), Kavi Devraj (441404), Artus, Cédric, Luigi Maddaluno, Cédric Artus (441405), Eleanna Papa, P. O. Couraud, Corada, Monica, Czupalla, Cathrin Jacqueline, Stefan Liebner, L. Maddaluno, Czupalla, Cathrin J., S. Liebner, Maddaluno, Luigi, Britta Engelhardt (307404), L. Ferrarini   +52 more
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Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases [PDF]

, 2023
Identification of therapeutic targets from genome-wide association studies (GWAS) requires insights into downstream functional consequences. We harmonized 8,613 RNA-sequencing samples from 14 brain datasets to create the MetaBrain resource and performed ...
van Rheenen, Wouter, Westra, Harm Jan, Vochteloo, Martijn, Gaunt, Tom R., Franke, Lude, Bakker, Mark K., Zavodszky, Maria I., Oelen, Roy, Ouyang, Zhengyu, Marshall, Eric E., El Garwany, Omar, Tsai, Ellen A., Runz, Heiko, Huang, Yunfeng, Bakker, Olivier B., Deelen, Patrick, de Klein, Niek, Chen, Chia Yen, Baird, Denis, van Dam, Sipko, Veldink, Jan   +20 more
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Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source