Results 31 to 40 of about 1,182,956 (263)

Uptake mechanism of ApoE-modified nanoparticles on brain capillary endothelial cells as a blood-brain barrier model

, 2012
Background: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases.
Tikva Vogel, Zensi, Anja, von Briesen Hagen, Kreuter Jörg, Worek Franz, Tschickardt, Sabrina E., Sascha L Wien, Jörg Kreuter, Wien Sascha L., Vogel Tikva, Sabrina E Tschickardt, Wladislaw Maier, Vogel, Tikva, Sylvia Wagner, Claus U Pietrzik, Maier Wladislaw, Zensi Anja, Wien, Sascha L., Maier, Wladislaw, Tschickardt Sabrina E., Wagner, Sylvia, Pietrzik Claus U., Anja Zensi, Kreuter, Jörg, Worek, Franz, Hagen von Briesen, Pietrzik, Claus Ulrich, Briesen, Hagen von, Wagner Sylvia, Franz Worek   +29 more
core   +1 more source

Hospitalization Through Families’ Eyes: Comparing Inpatient Care Quality for Children With Sickle Cell Disease and Cystic Fibrosis in Canada

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Sickle cell disease (SCD) is a chronic, inherited hemoglobinopathy that requires frequent hospitalization for disease‐related complications. Canadian data on inpatient care is limited. This study compared caregiver‐reported hospital experiences of children with SCD to those with cystic fibrosis (CF), a chronic, autosomal recessive ...
Hailey M. Zwicker, Kyle Kemp, Perri Tutelman, Sharon H. J. Hou, Paul Fairie, Maria Santana, Gregory M. T. Guilcher, Taryn Fay‐McClymont, Glenda Bendiak, Wendy Pelletier, Nicola Wright, Fiona Schulte   +11 more
wiley   +1 more source

Mean Expression of the X-Chromosome is Associated with Neuronal Density. [PDF]

, 2012
peer reviewedBackground: Neurodegenerative diseases are characterized by key features such as loss of neurons, astrocytosis, and microglial activation/proliferation. These changes cause differences in the density of cell types between control and disease
Pascal F. Durrenberger, James Thomas Swingland, Durrenberger, Pascal F, Swingland, James T., Reynolds, Richard, DEPREZ, Manuel, Pombo, A., Deprez, M, Roncaroli, F, Durrenberger, P.F., David T Dexter, Richard eReynolds, Dexter, DT, Turkheimer, Federico E; id_orcid, Turkheimer, Federico E., James T. Swingland, Ana Pombo, Federico Roncaroli, Turkheimer, FE, Swingland, J.T., Durrenberger, PF, David T. Dexter, Pombo, Ana, Dexter, David T, Durrenberger, Pascal F., Reynolds, R, Turkheimer, F.E., Manuel eDeprez, Swingland, James T, Federico E. Turkheimer, Dexter, D.T., Roncaroli, Federico, Federico eRoncaroli, Richard Reynolds, Reynolds, R., Turkheimer, Federico E, Manuel Deprez, Pombo, A, Pascal F Durrenberger, Ana ePombo, Dexter, David T., Deprez, M., Roncaroli, F., Swingland, JT   +43 more
core   +1 more source

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source

MRS in Motor Neuron Diseases

, 2016
Upper motor neurons (UMN) in the motor cortex and/or lower motor neurons (LMN) in the brainstem and spinal cord are affected in a heterogeneous group of related or pathologically similar adult-onset diseases, collectively termed as motor neuron diseases (
Varan Govind, Govind, Varan
core   +1 more source

Variation within the Huntington's disease gene influences normal brain structure. [PDF]

, 2011
Genetics of the variability of normal and diseased brain structure largely remains to be elucidated. Expansions of certain trinucleotide repeats cause neurodegenerative disorders of which Huntington's disease constitutes the most common example. Here, we
Juliane Winkelmann, Meisenzahl Eva M., Rujescu Dan, Rujescu, D., Giegling Ina, Gaser, C., Mühlau Mark, Eva M. Meisenzahl, Giegling, Ina, Winkelmann, Juliane, Winkelmann Juliane, Dan Rujescu, Meisenzahl, E.M., Adolph Weindl, Reiser Maximilian, Ina Giegling, Arsic, M., Winkelmann, J., Meisenzahl, Eva M., Koutsouleris Nikolaos, Gaser, Christian, Koutsouleris, Nikolaos, Christian Gaser, Reiser, M., Reiser, Maximilian, Gaser Christian, Mühlau, Mark, Giegling, I., Nikolaos Koutsouleris, Weindl Adolph, Mühlau, M., Arsic Milan, Mark Mühlau, Maximilian Reiser, Milan Arsic, Koutsouleris, N., Weindl, A., Weindl, Adolph, Eva M Meisenzahl, Arsic, Milan, Rujescu, Dan   +40 more
core   +1 more source

Increased Risk of Sarcomas in Children With Congenital Anomalies: Findings From the Genetic Overlap Between Anomalies and Cancer in Kids (GOBACK) Registry Linkage Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric sarcomas are a heterogeneous group of tumors that contribute disproportionately to cancer mortality in children. Although congenital anomalies are among the strongest known risk factors for childhood cancer, the risk of specific sarcoma subtypes among affected individuals has not yet been thoroughly evaluated. Procedure We
Russ Wolters, Ji Yun Tark, Tiffany M. Chambers, Tania A. Desrosiers, Michael E. Scheurer, Charles Shumate, Wendy N. Nembhard, Mahsa M. Yazdy, Eirini Nestoridi, Amanda E. Janitz, Jean Paul Tanner, Russell S. Kirby, Jason L. Salemi, Yao Yu, Chad D. Huff, Sharon E. Plon, Philip J. Lupo, Jeremy M. Schraw   +17 more
wiley   +1 more source

Evolutionary and genomic perspectives of brain aging and neurodegenerative diseases

, 2023
This chapter utilizes genomic concepts and evolutionary perspectives to further understand the possible links between typical brain aging and neurodegenerative diseases, focusing on the two most prevalent of these: Alzheimer's disease and Parkinson's ...
Rigby Dames, B.A, Kilili, H, Urrutia, A.O, Proulx, M.J, de Sousa, A.A, Díaz-Barba, K, Charvet, C.J   +6 more
core  

Efficacy and Safety Analysis of Roxarestat in Regulating Renal Anemia in Patients on Maintenance Hemodialysis

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Objective To compare the efficacy and safety of roxarestat versus recombinant human erythropoietin (rhEPO) in the management of renal anemia in patients undergoing maintenance hemodialysis. Methods This was a prospective, open‐label, randomized controlled trial.
Lingling Chen, Junjie Zhu, Qiaonan Ge
wiley   +1 more source

Therapeutic Apheresis for Intravenous Methylprednisolone‐Refractory Neuromyelitis Optica Spectrum Disorder: Clinical and Radiological Outcomes in a Single‐Center Case Series

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system. High‐dose intravenous methylprednisolone (IVMP) is the standard first‐line therapy for acute attacks, although some patients remain refractory.
Wataru Horiguchi, Daisuke Katagiri, Takeyuki Watadani, Shunichi Matsuda, Hiroshi Kaneko, Noritoshi Arai   +5 more
wiley   +1 more source