Results 291 to 300 of about 725,765 (358)

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Brain Energy Metabolism in Chronic Hepatic Encephalopathy: an in vivo and longitudinal Magnetic Resonance Spectroscopy study on a rat model of Biliary Cirrhosis

, 2017
André Rocha Morais
openalex   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Therapeutic modulation of energy metabolism in ischemic brain injury

Egor Y. Plotnikov, Nadezda V. Andrianova
openalex   +1 more source

AI‐Driven Acceleration of Fluorescence Probe Discovery

Advanced Science, EarlyView.
We present PROBY, an AI model trained on large‐scale datasets to predict key photophysical properties and accelerate the discovery of target‐specific fluorescent probes. By screening a target‐annotated library, PROBY identifies candidate probes for diverse targets and could guide probe optimization, enabling a range of in vitro and in vivo imaging ...
Xuefeng Jiang, Yanbo Li, Xue Tian, Sen Yang, Ruina Luo, Cenxing Zhou, Yuxuan Liu, Jingying Hu, Sen Feng, Lu Gan, Chongzhao Ran, Kun‐Hsing Yu, Junhan Zhao, Xiao Han, Xuan Zhai, Yuntao Jia, Jiapei Dai, Xiyue Wang, Biyue Zhu   +18 more
wiley   +1 more source

Glutamate Turnover and Energy Metabolism in Brain Injury : Clinical and Experimental Studies

, 2008
Carolina Samuelsson
openalex   +1 more source

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Energy Metabolism | Brain Energy Metabolism

Encyclopedia of Biological Chemistry III, 2021
A. Panov, S. Dikalov
semanticscholar   +2 more sources

Brain Energy Metabolism

Encyclopedia of Computational Neuroscience, 2018
D. Calvetti, E. Somersalo
semanticscholar   +2 more sources

Cyanidin 3-O-β-Galactoside Alleviated Cognitive Impairment in Mice by Regulating Brain Energy Metabolism During Aging.

Journal of Agricultural and Food Chemistry, 2022
Metabolic disorder, which commonly happens among senile people worldwide, is an important sign of aging. The early symptoms of neurodegenerative diseases include a decrease in energy metabolism and mitochondrial dysfunction.
Zhuoyan Fan, Haichao Wen, Xiaoxu Zhang, Jingming Li, J. Zang   +4 more
semanticscholar   +1 more source

Ibogaine affects brain energy metabolism

European Journal of Pharmacology, 2006
Ibogaine is an indole alkaloid present in the root of the plant Tabernanthe iboga. It is known to attenuate abstinence syndrome in animal models of drug addiction. Since the anti-addiction effect lasts longer than the presence of ibogaine in the body, some profound metabolic changes are expected.
Roman, Paskulin, Polona, Jamnik, Marko, Zivin, Peter, Raspor, Borut, Strukelj   +4 more
openaire   +2 more sources