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Microglia and Their Promising Role in Ischemic Brain Injuries: An Update

open access: yesFrontiers in Cellular Neuroscience, 2020
Ischemic brain injuries are common diseases with high morbidity, disability, and mortality rates, which have significant impacts on human health and life. Microglia are resident cells of the central nervous system (CNS).
Luting Yu   +11 more
doaj   +2 more sources

Mechanisms of team-sport-related brain injuries in children 5 to 19 years old: opportunities for prevention. [PDF]

open access: yesPLoS ONE, 2013
There is a gap in knowledge about the mechanisms of sports-related brain injuries. The objective of this study was to determine the mechanisms of brain injuries among children and youth participating in team sports.We conducted a retrospective case ...
Michael D Cusimano   +7 more
doaj   +2 more sources

The roles of pleiotrophin in brain injuries: a narrative review of the literature [PDF]

open access: yesAnnals of Medicine
Background Pleiotrophin (PTN), a secreted multifunctional growth factor, is highly expressed in the developing brain. Recently, many studies have indicated that PTN participates in the development of brain and plays a neuroprotection after brain injury ...
Yupeng Lei   +4 more
doaj   +2 more sources

A peptide for targeted, systemic delivery of imaging and therapeutic compounds into acute brain injuries

open access: yesNature Communications, 2016
Accurate treatment of traumatic brain injuries, a leading cause of neurological disability and death in young people, is hampered by poor accumulation of drugs in the brain.
Aman P. Mann   +14 more
doaj   +2 more sources

Microglia-Mediated Neurodegeneration in Perinatal Brain Injuries

open access: yesBiomolecules, 2021
Perinatal brain injuries, including encephalopathy related to fetal growth restriction, encephalopathy of prematurity, neonatal encephalopathy of the term neonate, and neonatal stroke, are a major cause of neurodevelopmental disorders.
B. Fleiss   +5 more
semanticscholar   +1 more source

Cerebrospinal Fluid and Blood Biomarkers in Patients with Post-Traumatic Disorders of Consciousness: A Scoping Review

open access: yesBrain Sciences, 2023
(1) Background: Cerebrospinal fluid (CSF) and blood biomarkers are emerging tools used to obtain information on secondary brain damage and to improve diagnostic and prognostic accuracy for patients with prolonged post-traumatic disorders of consciousness
Sergio Bagnato, Cristina Boccagni
doaj   +1 more source

Lumbosacral Sagittal Alignment in Association to Intervertebral Disc Diseases [PDF]

open access: yesAsian Spine Journal, 2014
Study DesignA cross-sectional case-control study was designed to compare the sagittal alignment of lumbosacral regions in two groups of patients suffering from low back pain, one with intervertebral disc pathologies and one without.PurposeTo evaluate the
Zohreh Habibi   +4 more
doaj   +1 more source

ROBOCOP (ROBOtic Care of Poststroke Pain): Study Protocol for a Randomized Trial to Assess Robot-Assisted Functional and Motor Recovery and Impact on Poststroke Pain Development

open access: yesFrontiers in Neurology, 2022
BackgroundStroke is one of the most frequent causes of death and disability worldwide. It is accompanied by the impaired motor function of the upper extremities in over 69% of patients up to hemiplegia in the following 5 years in 56% of cases.
Loris Pignolo   +5 more
doaj   +1 more source

HMGB1-Mediated Neuroinflammatory Responses in Brain Injuries: Potential Mechanisms and Therapeutic Opportunities

open access: yesInternational Journal of Molecular Sciences, 2020
Brain injuries are devastating conditions, representing a global cause of mortality and morbidity, with no effective treatment to date. Increased evidence supports the role of neuroinflammation in driving several forms of brain injuries.
Y. Paudel   +4 more
semanticscholar   +1 more source

Biomarkers of Brain Injury: A Window on Mechanisms of Injury and Recovery in the Brain

open access: yesBrain Sciences, 2022
The decision-making process regarding management after severe acute brain injury is based on clinical evaluation and depends on the injury etiology as well as radiological and neurophysiological data [...]
Sergio Bagnato
doaj   +1 more source

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