Results 51 to 60 of about 321,197 (357)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Transabdominal Functional Magnetic Stimulation for the Treatment of Constipation in Brain-Injured Patients: A Randomized Controlled Trial [PDF]

Annals of Rehabilitation Medicine, 2019
Objective To investigate the effects of the transabdominal functional magnetic stimulation (A-FMS) for constipation in stroke or brain-injured patients.
Young-Cheol Yun, Yong-Soon Yoon, Eun-Sil Kim, Young-Jae Lee, Jin-Gyeong Lee, Won-Jae Jo, Kwang Jae Lee   +6 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Safety of Intramedullary Autologous Peripheral Nerve Grafts for Post-Rehabilitated Complete Motor Spinal Cord Injuries: A Phase I Study

Acta Medica Iranica, 2013
Many experimental studies have reported behavioral improvement after transplantation of peripheral nerve tissue into the contused spinal cord, even in large animals. The safety of this treatment in human remains unknown.
Nazi Derakhshanrad, Hooshang Saberi, Sajad Shafiee, Mir Saeed Yekaninejad, Mohammad Reza Hadian, Abdolreza Sheikhrezai, Zahid Hussain Khan, Abbas Noruzi Javidan, Amir Hassan Kohan   +8 more
doaj  

Establishment and validation of a bad outcomes prediction model based on EEG and clinical parameters in prolonged disorder of consciousness

Frontiers in Human Neuroscience
ObjectiveThis study aimed to explore the electroencephalogram (EEG) indicators and clinical factors that may lead to poor prognosis in patients with prolonged disorder of consciousness (pDOC), and establish and verify a clinical predictive model based on
Wanqing Liu, Yongkun Guo, Yongkun Guo, Yongkun Guo, Jingwei Xie, Jingwei Xie, Jingwei Xie, Yanzhi Wu, Dexiao Zhao, Zhe Xing, Xudong Fu, Xudong Fu, Xudong Fu, Shaolong Zhou, Shaolong Zhou, Shaolong Zhou, Hengwei Zhang, Hengwei Zhang, Hengwei Zhang, Xinjun Wang, Xinjun Wang, Xinjun Wang, Xinjun Wang   +22 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Mild Brain Injury [PDF]

Rehabilitation Research and Practice, 2012
Mild traumatic brain injury (mTBI), commonly known as concussion, is one of the most common neurologic disorders [1]. Based on emergency room visits, hospitalizations, and deaths, an estimated 1.7 million people sustain a traumatic brain injury (TBI) annually in the United States [2]. About 80% of TBIs that occur each year are mild TBI [3].
Greenwald, Brian D., Ambrose, Anne Felicia, Armstrong, Gina P.   +2 more
openaire   +2 more sources

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

An Updated Overview of MRI Injuries in Neonatal Encephalopathy: LyTONEPAL Cohort

Children, 2022
Background: Brain magnetic resonance imaging (MRI) is a key tool for the prognostication of encephalic newborns in the context of hypoxic−ischemic events. The purpose of this study was to finely characterize brain injuries in this context.
Jonathan Beck, Gauthier Loron, Pierre-Yves Ancel, Marianne Alison, Lucie Hertz Pannier, Philippe Vo Van, Thierry Debillon, Nathalie Bednarek   +7 more
doaj   +1 more source