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Traumatic Brain Injury as a Chronic Health Condition

Archives of Physical Medicine and Rehabilitation, 2013
Growing evidence indicates that multiple types of brain injury, including traumatic brain injury, are dynamic conditions that continue to change years after onset. For a subset of individuals who incur these injuries, decline occurs over time and is likely due to progressive neurodegenerative processes, comorbid conditions, aging, behavioral choices ...
John D, Corrigan, Flora M, Hammond
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Fluid biomarkers of chronic traumatic brain injury

Nature Reviews Neurology
Traumatic brain injury (TBI) is a leading cause of long-term disability across the world. Evidence for the usefulness of imaging and fluid biomarkers to predict outcomes and screen for the need to monitor complications in the acute stage is steadily increasing.
Susanna Friberg, Caroline Lindblad, Frederick A. Zeiler, Henrik Zetterberg, Tobias Granberg, Per Svenningsson, Fredrik Piehl, Eric P. Thelin   +7 more
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Chronic traumatic brain injury in professional soccer players

Neurology, 1998
To determine the presence of chronic traumatic brain injury in professional soccer players.Fifty-three active professional soccer players from several professional Dutch soccer clubs were compared with a control group of 27 elite noncontact sport athletes. All participants underwent neuropsychological examination.
J T, Matser, A G, Kessels, B D, Jordan, M D, Lezak, J, Troost   +4 more
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Incidence of chronic pain following traumatic brain injury

Archives of Physical Medicine and Rehabilitation, 1996
To index the frequency of reported chronic pain in patients with traumatic brain injury (TBI).A case series study was conducted on consecutive patients with TBI.TBI patients were recruited from an adult tertiary care center brain injury clinic.A consecutive sample of 132 patients who attended a brain injury rehabilitation center after TBI.
S, Lahz, R A, Bryant
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Chronic Traumatic Brain Injury Associated with Boxing

Seminars in Neurology, 2000
Chronic traumatic brain injury (CTBI) associated with boxing occurs in approximately 20% of professional boxers. Risk factors associated with CTBI include increased exposure (i.e., duration of career, age of retirement, total number of bouts), poor performance, increased sparring, and apolipoprotein (APOE) genotype.
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Heart-rate variability in chronic traumatic brain injury

Brain Injury, 1997
Heart-rate variability (HRV), a measure of fluctuation around the mean heart rate, reflects the sympathetic and parasympathetic balance of the autonomic nervous system, and is an excellent technique to study cardiovascular tone in patients with neurological injuries. The purpose of this study was to determine whether abnormal HRV is present in patients
M L, King, S W, Lichtman, G, Seliger, F A, Ehert, J S, Steinberg   +4 more
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Chronic neurodegenerative consequences of traumatic brain injury

Restorative Neurology and Neuroscience, 2014
Traumatic brain injury (TBI) is a serious public health concern and a major cause of death and disability worldwide. Each year, an estimated 1.7 million Americans sustain TBI of which ~52,000 people die, ~275,000 people are hospitalized and 1,365,000 people are treated as emergency outpatients. Currently there are ~5.3 million Americans living with TBI.
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Magnesium in acute and chronic brain injury: an update

Magnesium Research, 2009
While brain free magnesium levels have been shown to decline in a number of acute and chronic brain pathologies, the mechanisms of such decline and the potential for magnesium administration as a therapeutic intervention are still unclear. In acute brain injury, magnesium therapy has failed in recent clinical trials of trauma, presumably because of an ...
Vink, R., Cook, N., Van Den Heuvel, C.
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Chronic alterations in rat brain α-adrenoceptors following traumatic brain injury

Restorative Neurology and Neuroscience, 1994
Norepinephrine (NE) has been implicated in cerebral plasticity and recovery of function after brain injury. To examine the status of noradrenergic mechanisms in the brain following traumatic brain injury (TBI), male Sprague-Dawley rats underwent right sensorimotor cortex contusions and were observed for the next 30 days for recovery of motor function ...
B E, Levin, S, Pan, A, Dunn-Meynell
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Functional Outcome in Chronic Traumatic Brain Injury

2022
Traumatic brain injury (TBI) is a disease process, rather than a single discrete event. Individuals with TBI experience variable sequelae and treatment needs across the acute, post-acute, and chronic stages after injury. It is estimated that 40% of individuals with a moderate to severe TBI will live with long-term disability.
Jillian M. Tessier, Maria Teresa Schultheis   +1 more
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