Results 31 to 40 of about 670,754 (306)

Brain Connectivity Predicts Chronic Pain in Acute Mild Traumatic Brain Injury

Annals of Neurology, 2022
ObjectivesPrevious studies have established the role of the cortico‐mesolimbic and descending pain modulation systems in chronic pain prediction. Mild traumatic brain injury (mTBI) is an acute pain model where chronic pain is prevalent and complicated for prediction. In this study, we set out to study whether functional connectivity (FC) of the nucleus
Noam Bosak, Paulo Branco, Pora Kuperman, Chen Buxbaum, Ruth Manor Cohen, Shiri Fadel, Rabab Zubeidat, Rafi Hadad, Amir Lawen, Noam Saadon‐Grosman, Michele Sterling, Yelena Granovsky, Apkar Vania Apkarian, David Yarnitsky, Itamar Kahn   +14 more
openaire   +2 more sources

Brain Microglial Activation in Chronic Pain-Associated Affective Disorder

Frontiers in Neuroscience, 2019
A growing body of evidence from both clinical and animal studies indicates that chronic neuropathic pain is associated with comorbid affective disorders.
Ellane Eda Barcelon, Woo-Hyun Cho, Sang Beom Jun, Sung Joong Lee   +3 more
doaj   +1 more source

RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury

Acta Neuropathologica Communications, 2021
Traumatic brain injury (TBI) causes acute and subacute tissue damage, but is also associated with chronic inflammation and progressive loss of brain tissue months and years after the initial event.
Antonia Clarissa Wehn, Igor Khalin, Marco Duering, Farida Hellal, Carsten Culmsee, Peter Vandenabeele, Nikolaus Plesnila, Nicole Angela Terpolilli   +7 more
doaj   +1 more source

Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons [PDF]

, 2008
Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions.
Arko Ghosh, Arsen Hunanyan, Damien D. Pearse, James W. Fawcett, John K. Robinson, Li Lou, Lisa Schnell, Lorne M. Mendell, Martin E. Schwab, Roobeh Golshani, Victor L. Arvanian   +10 more
core   +2 more sources

Neurotherapy for chronic headache following traumatic brain injury [PDF]

Military Medical Research, 2015
Chronic headache following traumatic brain injury (TBI) sustained in military service, while common, is highly challenging to treat with existing pharmacologic and non-pharmacologic interventions and may be complicated by co-morbid posttraumatic stress. Recently, a novel form of brainwave-based intervention known as the Flexyx Neurotherapy System (FNS)
David V. Nelson, Mary Lee Esty
openaire   +2 more sources

Diet-microbiome-gut-brain nexus in acute and chronic brain injury

Frontiers in Neuroscience, 2022
In recent years, appreciation for the gut microbiome and its relationship to human health has emerged as a facilitator of maintaining healthy physiology and a contributor to numerous human diseases. The contribution of the microbiome in modulating the gut-brain axis has gained significant attention in recent years, extensively studied in chronic brain ...
Maria Alexander Krakovski, Niraj Arora, Shalini Jain, Jennifer Glover, Keith Dombrowski, Beverly Hernandez, Hariom Yadav, Hariom Yadav, Anand Karthik Sarma, Anand Karthik Sarma   +9 more
openaire   +3 more sources

Overexpression of IL-1β by adenoviral-mediated gene transfer in the rat brain causes a prolonged hepatic chemokine response, axonal injury and the suppression of spontaneous behaviour

Neurobiology of Disease, 2007
Acute brain injury induces early and transient hepatic expression of chemokines, which amplify the injury response and give rise to movement of leukocytes into the blood and subsequently the brain and liver.
Sandra J. Campbell, Rob M.J. Deacon, Yanyan Jiang, Carina Ferrari, Fernando J. Pitossi, Daniel C. Anthony   +5 more
doaj   +1 more source

Intravenous Infusion of Autoserum-Expanded Autologous Mesenchymal Stem Cells in Patients With Chronic Brain Injury: Protocol for a Phase 2 Trial

JMIR Research Protocols, 2022
BackgroundBrain injuries resulting from motor vehicle accidents and falls, as well as hypoxic insults and other conditions, are one of the leading causes of disability and death in the world.
Shinichi Oka, Tomohiro Yamaki, Masanori Sasaki, Ryo Ukai, Mitsuhiro Takemura, Takahiro Yokoyama, Yuko Kataoka-Sasaki, Rie Onodera, Yoichi M Ito, Shigeki Kobayashi, Jeffery D Kocsis, Yasuo Iwadate, Osamu Honmou   +12 more
doaj   +1 more source

Deplete and repeat: microglial CSF1R inhibition and traumatic brain injury

Frontiers in Cellular Neuroscience
Traumatic brain injury (TBI) is a public health burden affecting millions of people. Sustained neuroinflammation after TBI is often associated with poor outcome.
Rebecca Boland, Olga N. Kokiko-Cochran
doaj   +1 more source

Addressing the needs of traumatic brain injury with clinical proteomics. [PDF]

, 2014
BackgroundNeurotrauma or injuries to the central nervous system (CNS) are a serious public health problem worldwide. Approximately 75% of all traumatic brain injuries (TBIs) are concussions or other mild TBI (mTBI) forms.
Loo, Joseph A, Loo, Rachel R Ogorzalek, Shen, Sean, Wanner, Ina-Beate   +3 more
core   +1 more source