Results 71 to 80 of about 670,754 (306)

Making Waves in the Brain: What Are Oscillations, and Why Modulating Them Makes Sense for Brain Injury. [PDF]

, 2016
Traumatic brain injury (TBI) can result in persistent cognitive, behavioral and emotional deficits. However, the vast majority of patients are not chronically hospitalized; rather they have to manage their disabilities once they are discharged to home ...
Gurkoff, Gene G, Izadi, Ali, Lee, Darrin J, Pevzner, Aleksandr, Shahlaie, Kiarash   +4 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Evaluation of secretome biomarkers in glioblastoma cancer stem cells: A bioinformatics analysis

Cancer Reports
Background Glioblastoma (GBM) is a malignant brain tumor that frequently occurs alongside other central nervous system (CNS) conditions. The secretome of GBM cells contains a diverse array of proteins released into the extracellular space, influencing ...
Ehsan Jangholi, Hoda Ahmari Tehran, Afsaneh Ghasemi, Mohammad Hoseinian, Sina Firoozi, Seyed Mohammad Ghodsi, Mona Tamaddon, Ahmad Bereimipour, Mahmoudreza Hadjighassem   +8 more
doaj   +1 more source

Is traumatic and non-traumatic neck pain associated with brain alterations? : a systematic review [PDF]

, 2017
Background: Chronic neck pain affects 50% - 85% of people who have experienced an acute episode. This transition and the persistence of chronic complaints are believed to be mediated by brain alterations among different central mechanisms.
Caeyenberghs, Karen, Cagnie, Barbara, Coppieters, Iris, Danneels, Lieven, De Pauw, Robby, Meeus, Mira   +5 more
core  

Moderators, mediators and nonspecific predictors of outcome after cognitive rehabilitation of executive functions in a randomised controlled trial [PDF]

, 2017
Moderators, mediators and nonspecific predictors of treatment after cognitive rehabilitation of executive functions in a randomised controlled trial Objective: To explore moderators, mediators and nonspecific predictors of executive functioning after ...
Evans, Jonathan, Løvstad, Marianne, Schanke, Anne-Kristine, Solbakk, Anne-Kristin, Stubberud, Jan, Tornås, Sveinung   +5 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability

Journal of Neuroinflammation
Traumatic brain injury is a leading cause of chronic neurologic disability and a risk factor for development of neurodegenerative disease. However, little is known regarding the pathophysiology of human traumatic brain injury, especially in the window ...
Alicia B. Feichtenbiner, Karinn Sytsma, Ryan P. O’Boyle, Rhonda Mittenzwei, Heather Maioli, Kathryn P. Scherpelz, Daniel D. Child, Ning Li, Jeanelle Ariza Torres, Lisa Keene, Amanda Kirkland, Kimberly Howard, Caitlin Latimer, C. Dirk Keene, Christopher Ransom, Amber L. Nolan   +15 more
doaj   +1 more source

A model for estimating the brainstem volume in normal healthy individuals and its application to diffuse axonal injury patients

Scientific Reports, 2023
Diffuse axonal injury (DAI) is a subtype of traumatic brain injury that causes acute-phase consciousness disorders and widespread chronic-phase brain atrophy.
Gaku Fujimoto, Shiho Ubukata, Genichi Sugihara, Naoya Oishi, Toshihiko Aso, Toshiya Murai, Keita Ueda   +6 more
doaj   +1 more source

The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy. [PDF]

, 2015
Chronic traumatic encephalopathy (CTE) is a neurodegeneration characterized by the abnormal accumulation of hyperphosphorylated tau protein within the brain. Like many other neurodegenerative conditions, at present, CTE can only be definitively diagnosed
Alvarez, Victor E, Bieniek, Kevin F, Cairns, Nigel J, Crary, John F, Dams-O'Connor, Kristen, Dickson, Dennis W, Folkerth, Rebecca D, Gordon, Wayne A, Keene, C Dirk, Litvan, Irene, McKee, Ann C, Perl, Daniel P, Stein, Thor D, Stewart, William, TBI/CTE group, Tripodis, Yorghos, Vonsattel, Jean-Paul   +16 more
core   +3 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source