Results 81 to 90 of about 4,355,570 (357)

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

429 End user feedback on the Revised Department of Defense (DoD) Progressive Return to Activity (PRA): Primary Care for Acute Concussion Management Clinical Recommendation (CR)

Journal of Clinical and Translational Science
Objectives/Goals: The objectives of the study were to evaluate end-user feedback regarding usefulness and compliance with the revised DoD PRA-CR. The PRA-CR utilizes symptom-guided management strategies to advance service members with acute concussion ...
Jacques Arrieux, Jacques Arrieux, M. Victoria Ingram, Aaron Robinson, Seth Kiser, Rachel Lardieri, Keith Stuessi   +6 more
doaj   +1 more source

Change in structural brain network abnormalities after traumatic brain injury determines post-injury recovery [PDF]

arXiv, 2022
The trajectory of an individual's recovery after traumatic brain injury (TBI) is heterogeneous, with complete recovery in some cases but persistent disability in others. We hypothesized that changes in structural brain network abnormalities guide the trajectory of an individual's recovery post-injury.
arxiv  

Catecholamines and cognition after traumatic brain injury [PDF]

, 2016
Cognitive problems are one of the main causes of ongoing disability after traumatic brain injury. The heterogeneity of the injuries sustained and the variability of the resulting cognitive deficits makes treating these problems difficult. Identifying the
Jenkins, PO, Mehta, MA, Sharp, DJ
core   +2 more sources

Association of Socioeconomic Status and Brain Injury With Neurodevelopmental Outcomes of Very Preterm Children

JAMA Network Open, 2019
Key Points Question Does the association of brain injury with adverse neurodevelopmental outcome in preterm neonates vary by the socioeconomic status of the parents? Findings In this cohort study of 226 preterm neonates, cognitive and motor outcomes were
Isabel Benavente-Fernández, A. Synnes, R. Grunau, V. Chau, C. Ramraj, Torin Glass, Dalit Cayam-Rand, A. Siddiqi, Steven P. Miller   +8 more
semanticscholar   +1 more source

HDAC4 regulates apoptosis in Acan‐CreERT2;HDAC4d/d mice with osteoarthritis by downregulating ATF4

FEBS Open Bio, EarlyView.
Using the AcanCreERT2;HDAC4fl/fl genetic mouse model, we further investigated the role of histone deacetylase 4 (HDAC4) in chondrocyte apoptosis. We found that knocking down HDAC4 may be associated with chondrocyte apoptosis by upregulating the activating transcription factor 4 (ATF4)/CAAT/enhancer binding protein homologous (CHOP) signaling pathway ...
Jingrui Huang, Yukun Xu, Yujia Li, Yiming Pang, Xueting Ding, Raorao Zhou, Dan Liang, Xianda Che, Yuanyu Zhang, Chunfang Wang, Wenjin Li, Pengcui Li   +11 more
wiley   +1 more source

Traumatic brain injury: Age at injury influences dementia risk after TBI [PDF]

, 2015
Traumatic brain injury (TBI) is increasingly recognized as a risk factor for dementia. New data provide further support for this association and demonstrate the influence of age at injury and injury severity on dementia risk after TBI, revealing that ...
AC McKee, CW Hukkelhoven, DH Smith, GM Savva, M Susman, RC Gardner, S Fleminger, VE Johnson, VE Johnson, Victoria E. Johnson, William Stewart   +10 more
core   +1 more source

Acacetin reduces endoplasmic reticulum stress through the P‐eNOS/PERK signaling pathway to attenuate MGO‐induced vascular endothelial cell dysfunction

FEBS Open Bio, EarlyView.
We investigated a potential protective effect of acacetin, a naturally occurring flavonoid, against methylglyoxal (MGO)‐induced endothelial dysfunction in human umbilical vein endothelial cells and its mechanism of action. Acacetin can could inhibit MGO‐induced intracellular calcium ion influx, enhance the expression levels of phosphorylated ...
Zhen Zhang, Kaien Hu, Zhaohui Fang, Sihai Wang, Jie Chen, Dengke Yin, Caiyun Zhang, Gefei Ma   +7 more
wiley   +1 more source

Sex & gender considerations in concussion research

Concussion, 2018
The study of concussion, a common form of mild traumatic brain injury, has received increased notice over the last decade. Recently, more researchers have been addressing the historic paucity of attention over sex and gender influences on recovery ...
Tatyana Mollayeva, Graziella El-Khechen-Richandi, Angela Colantonio   +2 more
doaj   +1 more source