Results 111 to 120 of about 329,254 (353)

Neuroprotective Effects of Exercise on Brain Edema and Neurological Movement Disorders Following the Cerebral Ischemia and Reperfusion in Rats

Basic and Clinical Neuroscience, 2017
Introduction: Cerebral ischemia and reperfusion causes physiological and biochemical changes in the neuronal cells that will eventually lead to cell damage.
Nabi Shamsaei, Soheila Erfani, Masoud Fereidoni, Ali Shahbazi   +3 more
doaj  

Adjusting Cell‐Surface Interactions Through a Covalent Immobilization of Biomolecules

Advanced Materials Interfaces, EarlyView.
This review presents an overview of current and emerging immobilization techniques coupled with an in‐depth investigation of the underlying mechanisms governing the activity and stability of covalently immobilized biomolecules. The aim of this study is to serve as a guide for the development of long‐lasting biomedical coatings with versatile biological
Sara Shakibania, Manus J. P. Biggs, Katarzyna Krukiewicz   +2 more
wiley   +1 more source

Transparent Temperature Sensors for Photothermal Neuromodulation: Advances, Challenges, and Future Directions

Advanced Materials Interfaces, EarlyView.
Photothermal neuromodulation is a promising technique for versatile neural signal study and treatment development. To further develop these technologies and optimize their effectiveness, transparent electrical temperature sensors with high thermal sensitivity and resolution are essential for accurately monitoring temperature changes during ...
Jee Woong Lee, Junhee Lee, Jungha Lee, Duhee Kim, Woongki Hong, Junghyup Lee, Minyoung Song, Hongki Kang   +7 more
wiley   +1 more source

Neutralizing anti-interleukin-1β antibodies modulate fetal blood–brain barrier function after ischemia

Neurobiology of Disease, 2015
We have previously shown that increases in blood–brain barrier permeability represent an important component of ischemia–reperfusion related brain injury in the fetus.
Xiaodi Chen, Grazyna B. Sadowska, Jiyong Zhang, Jeong-Eun Kim, Erin E. Cummings, Courtney A. Bodge, Yow-Pin Lim, Oleksandr Makeyev, Walter G. Besio, John Gaitanis, Steven W. Threlkeld, William A. Banks, Barbara S. Stonestreet   +12 more
doaj  

Delayed treatment with nimesulide reduces measures of oxidative stress following global ischemic brain injury in gerbils [PDF]

Neuroscience Research 47(2): 245-253 (2003), 2007
Metabolism of arachidonic acid by cyclooxygenase is one of the primary sources of reactive oxygen species in the ischemic brain. Neuronal overexpression of cyclooxygenase-2 has recently been shown to contribute to neurodegeneration following ischemic injury.
arxiv  

Analytic and Numerical Models of Oxygen and Nutrient Diffusion, Metabolism Dynamics, and Architecture Optimization in Three-Dimensional Tissue Constructs with Applications and Insights in Cerebral Organoids [PDF]

, 2015
Diffusion models are important in tissue engineering as they enable an understanding of molecular delivery to cells in tissue constructs. As three-dimensional (3D) tissue constructs become larger, more intricate, and more clinically applicable, it will be essential to understand internal dynamics and signaling molecule concentrations throughout the ...
arxiv   +1 more source

The Role of Silicon Technology in Organ‐On‐Chip: Current Status and Future Perspective

Advanced Materials Technologies, EarlyView.
This review explores the potential of silicon micro‐nanofabrication technologies in advancing organ‐on‐chip systems. The integration of actuation and sensing modalities, highlight emerging technologies is discussed for combining silicon‐based and polymer‐based components, and emphasize the need for robust, high‐throughput, and customizable organ‐on ...
Frøydis Sved Skottvoll, Enrique Escobedo‐Cousin, Michal Marek Mielnik   +2 more
wiley   +1 more source

Pyrrolidine dithiocarbamate attenuates brain Aβ increase and improves long-term neurological outcome in rats after transient focal brain ischemia

Neurobiology of Disease, 2012
Evidence suggests an association between brain ischemia and Alzheimer's disease (AD) development. Amyloid plaques consisted of β-amyloid peptide (Aβ) in the brain are a pathological hallmark of AD. Little is known about how brain ischemia induces AD-like
Jiejie Li, Wenli Sheng, Chenzhuo Feng, Zhiyi Zuo   +3 more
doaj  

ADAMTS13 gene deletion enhances plasma high-mobility group box1 elevation and neuroinflammation in brain ischemia-reperfusion injury [PDF]

, 2018
Highly adhesive glycoprotein von Willebrand factor (VWF) multimer induces platelet aggregation and leukocyte tethering or extravasation on the injured vascular wall, contributing to microvascular plugging and inflammation in brain ischemia-reperfusion. A
Akitake, Yoshiharu, Banno, Fumiaki, Fujioka, Masayuki, Fujiwara, Michihiro, Hayakawa, Kazuhide, Irie, Keiichi, Iwasaki, Katsunori, Kokame, Koichi, Mishima, Kenichi, Miyata, Toshiyuki, Muroi, Carl, Nakano, Takafumi, Nishio, Kenji, Okuchi, Kazuo, Sakamoto, Yuya, Siesjö, Bo, Yonekawa, Yasuhiro   +16 more
core  

Achieving Optimal Health With Host‐Directed Therapies (HDTs) in Infectious Diseases—A New Horizon

Advanced Therapeutics, EarlyView.
Host‐directed therapies (HDTs) represent a transformative approach in infectious disease management by targeting host factors to enhance immune responses and inhibit viral replication. This innovative strategy leverages advanced genomics and gene editing technologies, offering promising avenues for improved patient outcomes and a new horizon in ...
Amol D. Gholap, Pankaj R. Khuspe, Sagar R. Pardeshi, Md Jasim Uddin, Ushasi Das, Navnath T. Hatvate, Satish Rojekar, Prabhanjan Giram, Mohammad Khalid, Yahya E. Choonara, Md. Faiyazuddin   +10 more
wiley   +1 more source