Results 91 to 100 of about 2,097,140 (305)

Nuclear localization of the hypoxia-regulated pro-apoptotic protein BNIP3 after global brain ischemia in the rat hippocampus

, 2004
The 19 kD interacting protein 3, Nip3/BNIP3, is a pro-apoptotic member of the Bcl-2 family induced during hypoxia via the hypoxia-inducible factor (HIF) 1.
Aguirre-Chen, Cristina, Kietzmann, Thomas, Ginsberg, M. D., Saul, I., Ginsberg, Myron D, Busto, R., Saul, Isabel, Schmidt-Kastner, R., Schmidt-Kastner, Rainald, Aguirre-Chen, C., Busto, Raul   +10 more
core   +1 more source

Diabetes‐Associated Cognitive Impairment: Pathophysiology and Emerging Therapies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Diabetes‐associated cognitive impairment (DACI) is a common yet underrecognized condition, manifesting along a spectrum from mild cognitive impairment to dementia. DACI encompasses patients who develop vascular dementia (VaD) or Alzheimer's disease (AD) with diabetes as a risk factor; however, in certain patients, particularly those lacking ...
Osman Corbali, Priyanka Menon, Halil I. Corbali, Ram Jagannathan, Allan I. Levey   +4 more
wiley   +1 more source

Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat

, 1998
The immunosuppressant drug cyclosporin A (CsA) is considered to be inherently protective in conditions of ischemia, e.g. in hepatic and cardiac tissue. However, investigations of effects of CsA on neuronal tissue have been contradictory, probably because
Li, P A, Uchino, K, He, Q P, Elmer, Eskil,, Uchino, H, Lund University., Smith, Maj-Lis,, Siesjö, Bo,   +7 more
core   +2 more sources

Evaluation of lipid peroxidation, cathepsin L and acid phosphatase activities in experimental brain ischemia-reperfusion

, 1999
This investigation was conducted in rat brain tissues to elucidate the free radical induced cellular and subcellular membrane injuries in two different depth of global ischemia.
Ozdamar, N, Guner, G, Islekel, S, Islekel, H, Nurcan Özdamar, Gül Güner, Sertaç İşlekel, Hüray İşlekel   +7 more
core   +1 more source

Transient limb ischemia induces remote ischemic preconditioning in vivo [PDF]

, 2002
Background-Ischemic preconditioning reduces local tissue injury caused by subsequent ischemia-reperfusion (IR), but may also have a salutary effect on IR injury of tissues remote from those undergoing preconditioning.
Hoschtitzky, JA, Sorensen, K, Redington, AN, Mortensen, UM, Kristiansen, SB, Kharbanda, RK, Vogel, M, White, PA, Schmidt, MR, MacAllister, R   +9 more
core   +1 more source

Vascular Disease, Non‐Steroidal Anti‐Inflammatory Drugs and Risk of Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives A history of vascular disease has been shown to be associated with an increased risk of Parkinson's disease, but this may be due to reverse causation. In addition, non‐steroidal anti‐inflammatory drugs are thought to reduce Parkinson's disease risk, but evidence is inconsistent and confounding by prior vascular disease is possible ...
Clare Wotton, Carol Hermon, Sarah Floud, Gillian Reeves, Isobel Barnes   +4 more
wiley   +1 more source

Neurovascular Mechanisms of Ischemia Tolerance Against Brain Injury

, 2013
Traumatic brain injury (TBI) can result in secondary ischemia. This secondary ischemic insult is implicated in post-TBI pathophysiology. Pharmacological intervention to elevate cerebral blood flow can improve outcomes following TBI.
John W. Thompson, Lin, Hung W, Kunjan R. Dave, Perez-Pinzon, Miguel A, Hung W. Lin, Miguel A. Perez-Pinzon, Neumann, Jake T, Jake T. Neumann, Dave, Kunjan R, Thompson, John W   +9 more
core   +1 more source

Ischemia–reperfusion impairs blood–brain barrier function and alters tight junction protein expression in the ovine fetus [PDF]

, 2012
The blood–brain barrier is a restrictive interface between the brain parenchyma and the intravascular compartment. Tight junctions contribute to the integrity of the blood–brain barrier.
Sadowska, G. B., Threlkeld, S. W., Makeyev, O., Besio, W. G., Stonestreet, B. S., Gaitanis, J., Cummings, E. E., Juan, I., Chen, X., Banks, W. A.   +9 more
core   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil   +9 more
wiley   +1 more source

CD147 as a key mediator of the spleen inflammatory response in mice after focal cerebral ischemia

Journal of Neuroinflammation, 2019
Background The splenic inflammatory response after cerebral ischemia has been implicated in secondary brain injury. We have recently reported that CD147 plays an important role in driving brain inflammation after ischemic stroke.
Rong Jin, Wei Zhong, Shan Liu, Guohong Li   +3 more
doaj   +1 more source