Results 131 to 140 of about 2,529,991 (308)

Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α

Stem Cell Research & Therapy, 2017
Background Blood-brain barrier impairment is a major indicator of endothelial dysfunction in diabetes. Studies showed that endothelial progenitor cell (EPC) transplantation promoted angiogenesis and improved function recovery after hind limb ischemia in ...
Jieli Geng, Liping Wang, Meijie Qu, Yaying Song, Xiaojie Lin, Yajing Chen, Muyassar Mamtilahun, Shengdi Chen, Zhijun Zhang, Yongting Wang, Guo-Yuan Yang   +10 more
doaj   +1 more source

Responsive Mn‐Ferrite Nanoparticles for Multicolor Magnetic Particle Imaging, Sensing, and Reactive Oxygen Species Degradation

Advanced Sensor Research, EarlyView.
Magnetic particle spectroscopy and imaging represent promising tools, particularly when combined with manganese‐ferrite nanoparticles as versatile theranostic agents. Adjusting the manganese content allows for simultaneous multi‐color tracer detection and reactive oxygen species sensing via magnetic particle spectroscopy and imaging, creating new ...
Fabian H. L. Starsich, Julia Feye, Robert Niβler, Gabriela Da Silva André, Elena Totter, Konrad Scheffler, Florian Thieben, Erik Mayr, Jochen Franke, Tobias Knopp, Inge K. Herrmann   +10 more
wiley   +1 more source

Inflammation Combined with Ischemia Produces Myelin Injury and Plaque-Like Aggregates of Myelin, Amyloid-β and AβPP in Adult Rat Brain. [PDF]

, 2015
BackgroundIschemia, white matter injury, and Alzheimer's disease (AD) pathologies often co-exist in aging brain. How one condition predisposes to, interacts with, or perhaps causes the others remains unclear.ObjectivesTo better understand the link ...
Ander, Bradley P, Cox, Christopher, Jickling, Glen C, Jin, Lee-Way, Liu, Dazhi, Sharp, Frank R, Stamova, Boryana, Zhan, Xinhua   +7 more
core  

A depletable pool of adenosine in area CA1 of the rat hippocampus [PDF]

, 2001
Adenosine plays a major modulatory and neuroprotective role in the mammalian CNS. During cerebral metabolic stress, such as hypoxia or ischemia, the increase in extracellular adenosine inhibits excitatory synaptic transmission onto vulnerable neurons via
Caldwell, Darren, Dale, Nicholas, Frenguelli, Bruno G., Nuritova, Feruza, Pearson, Tim   +4 more
core   +1 more source

Intrinsically Soft Implantable Electronics for Long‐term Biosensing Applications

Advanced Sensor Research, EarlyView.
Intrinsically soft implantable biosensors address the mechanical mismatch of conventional rigid implants, improving biocompatibility and stability. This review explores soft encapsulation matrices, stretchable conductors, implantation strategies, and chronic fixation techniques.
Su Hyeon Lee, Hyo Jin Lee, Lee, Dae‐Hyeong Kim, Hye Jin Kim, Sung‐Hyuk Sunwoo   +5 more
wiley   +1 more source

Requirement for preclinical prioritization of neuroprotective strategies in stroke: Incorporation of preconditioning [PDF]

Conditioning Medicine, 2018, 2019
Acute neuroprotection in numerous human clinical trials has been an abject failure. Major systemic-and procedural-based issues have subsequently been identified in both clinical trials and preclinical animal model experimentation. As well, issues related to the neuroprotective moiety itself have contributed to clinical trial failures, including late ...
arxiv  

Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model [PDF]

, 2019
Introduction: Hypothermia attenuates cerebral ischemia-induced neuronal cell death associated with neuroinflammation. The calcineurin inhibitor cyclosporin A (CsA) has been shown to be neuroprotective by minimizing activation of inflammatory pathways.
Berger, Felix, Krech, Jana, Rolfs, Nele, Schmitt, Katharina R. L., Tong, Giang, Wowro, Sylvia J.   +5 more
core   +1 more source

FUS Selectively Facilitates circRNAs Packing into Small Extracellular Vesicles within Hypoxia Neuron

Advanced Science, EarlyView.
This study aimed to unravel the role of FUS in the loading of functional circRNAs into neuronal sEVs under hypoxic conditions, which involves their aggregations in SGs and specific interaction between the FUS Zf_RanBP domain to regulate circRNA sorting in sEVs.
Jiankun Zang, Yousheng Wu, Xuanlin Su, Kaiwei Cai, Man Ke, Niu He, Huili Zhu, Zefeng Tan, Jielin Zhu, Wensheng He, Min Peng, Shiqing Zhang, Hongcheng Mai, Anding Xu, Dan Lu   +14 more
wiley   +1 more source

Vulnerability of white matter to ischemia varies during development [PDF]

, 2011
Stroke is the one of the leading causes of mortality and morbidity in developed countries. The central role of injury to white matter in the pathophysiology of stroke has been recognised over the recent years.
Di Giovanni, Giuseppe, Muscat, Richard, Pierucci, Massimo, Valentino, Mario, Zammit, Christian   +4 more
core  

Protective Action of Indapamide, a Thiazide-Like Diuretic, on Ischemia-Induced Injury and Barrier Dysfunction in Mouse Brain Microvascular Endothelial Cells

Journal of Pharmacological Sciences, 2007
The aim of the present study was to elucidate the effects of indapamide on ischemic damage to the blood-brain barrier (BBB) in vitro. The ischemia /reperfusion conditions employed here significantly decreased the viability of mouse brain capillary ...
Tsuyoshi Nishioku, Fuyuko Takata, Atsushi Yamauchi, Noriko Sumi, Ikumi Yamamoto, Akiko Fujino, Mikihiko Naito, Takashi Tsuruo, Hideki Shuto, Yasufumi Kataoka   +9 more
doaj