The Mechanism and Potential Therapeutic Strategies of Vascular Aging
The phenotypes of vascular aging vary across different blood vessels. Endothelial dysfunction is observable in the endothelium of all vessels, while vascular structural remodeling primarily occurs in arteries. A decline in organ vascular density mainly affects arterioles, venules, and capillaries, whereas thrombosis predominantly occurs in the ...
Wan‐Zhou Wu+4 more
wiley +1 more source
A neural cell automated analysis system based on pathological specimens in a gerbil brain ischemia model. [PDF]
Katsumata E+12 more
europepmc +1 more source
Conditional Survival for Pancreas Graft and Its Associated Factors After Pancreas Transplantation
This study investigates conditional survival (CS) for pancreas grafts in recipients of pancreas transplantation (PTx) in Japan, using data from 526 cases. Findings reveal that CS increases over time post‐transplant, offering a more optimistic long‐term prognosis than traditional actuarial survival. While donor sex and PTx procedure type influence early
Yoshito Tomimaru+5 more
wiley +1 more source
CD8<sup>+</sup>GZMK<sup>+</sup>CD27<sup>+</sup>CCR7<sup>+</sup> T cells mobilized by splenic sympathetic nerves aggravate brain ischemia‒reperfusion injury via CCL19-positive endothelial cells. [PDF]
Bai Y+21 more
europepmc +1 more source
Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei+8 more
wiley +1 more source
METTL3 mediates m6A modification of lncRNA CRNDE to promote ATG10 expression and improve brain ischemia/reperfusion injury through YTHDC1. [PDF]
Yu Z+6 more
europepmc +1 more source
Increased expression and specific localization of cathepsin H in rat brain by forebrain ischemia.
Tutomu Amano+2 more
openalex +1 more source
Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine
Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang+7 more
wiley +1 more source
Temporal expression profiles of microRNAs associated with acute phase of brain ischemia in gerbil hippocampus. [PDF]
Hamada Y+11 more
europepmc +1 more source