Results 101 to 110 of about 791,856 (290)

CamBAfx: workflow design, implementation and application for neuroimaging

Frontiers in Neuroinformatics, 2009
CamBAfx is a workflow application designed for both researchers who use workflows to process data (consumers) and those who design them (designers). It provides a front-end (user interface) optimized for data processing designed in a way familiar to ...
Cinly Ooi, Cinly Ooi, Edward T Bullmore, Edward T Bullmore, Alle-Meije Wink, Levent Sendur, Levent Sendur, Anna Barnes, Anna Barnes, Sophie Achard, Sophie Achard, John Aspden, Sanja Abbott, Shigang Yue, Manfred Kitzbichler, David Meunier, David Meunier, Voichita Maxim, Voichita Maxim, Raymond Salvador, Julian Henty, Julian Henty, Roger Tait, Roger Tait, Naresh Subramaniam, John Suckling, John Suckling   +26 more
doaj   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Self-related thought alterations associated with intrinsic brain dysfunction in mild cognitive impairment

Scientific Reports
The subjective experience of self-awareness is attributed to the human capacity for introspective thought during periods of mind-wandering. However, how this cognitive function is impacted in individuals with mild cognitive impairment (MCI) still needs ...
Povilas Tarailis, Kim Lory, Paul G. Unschuld, Christoph M. Michel, Lucie Bréchet   +4 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Cognitive impairment in neuromuscular diseases: A systematic review

Neurology International, 2018
Neuromuscular diseases are multifactorial pathologies characterized by extensive muscle fiber damage that leads to the activation of satellite cells and to the exhaustion of their pool, with consequent impairment of neurobiological aspects, such as ...
Marco Orsini, Ana Carolina Andorinho de F. Ferreira, Anna Carolina Damm de Assis, Thais Magalhães, Silmar Teixeira, Victor Hugo Bastos, Victor Marinho, Thomaz Oliveira, Rossano Fiorelli, Acary Bulle Oliveira, Marcos R. G. de Freitas   +10 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression

Brain and Behavior
Introduction Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc).
Brandon Taraku, Joana R. Loureiro, Ashish K. Sahib, Artemis Zavaliangos‐Petropulu, Noor Al‐Sharif, Amber M. Leaver, Benjamin Wade, Shantanu Joshi, Roger P. Woods, Randall Espinoza, Katherine L. Narr   +10 more
doaj   +1 more source

Subcortical electrophysiological activity is detectable with high-density EEG source imaging

Nature Communications, 2019
Electroencephalography (EEG) allows the measurement of electrical signals associated with brain activity, but it is unclear if EEG can accurately measure subcortical activity.
Martin Seeber, Lucia-Manuela Cantonas, Mauritius Hoevels, Thibaut Sesia, Veerle Visser-Vandewalle, Christoph M. Michel   +5 more
doaj   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source