Results 101 to 110 of about 2,845,885 (265)

Multimodal imaging improves brain age prediction and reveals distinct abnormalities in patients with psychiatric and neurological disorders

, 2020
The deviation between chronological age and age predicted using brain MRI is a putative marker of overall brain health. Age prediction based on structural MRI data shows high accuracy in common brain disorders.
Karin Persson, Richard, Geneviève, Jaroslav Rokicki, Ann‐Marie G. de Lange, Schwarz, Emanuel, Selbæk, Geir, Nordvik, Jan Egil, Ingrid Agartz, Thomas Wolfers, de Lange, Ann-Marie Glasø, Wibeke Nordhøy, Rokicki, Jaroslav, Lund, Martina Jonette, Norbom, Linn Christin Bonaventure, Quintana, Daniel, Dag Alnæs, Persson, Karin Ester Torun, Lars T. Westlye, Ingrid Melle, Genevieve Richard, Agartz, Ingrid, Martina J. Lund, Westlye, Lars Tjelta, Emanuel Schwarz, Tobias Kaufmann, Geir Selbæk, Melle, Ingrid, Kaufmann, Tobias, Ole A. Andreassen, Andreassen, Ole Andreas, Natalia Tesli, Linn Norbom, Terje Nærland, Nærland, Terje, Tesli, Natalia, Nordhøy, Wibeke, Daniel S. Quintana, Wolfers, Thomas, Jan Egil Nordvik, Alnæs, Dag, Norbom, L, Wolfers, T, Rokicki, J, Richard, G, de, Lange A-MG, Nordhoy, W, Quintana, DS, Tesli, N, Lund, MJ, Alnaes, D   +49 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

[New Guinea, scale 1:63,360] [cartographic material] /

, 1955
Provisional ed. Uncontoured (planimetric) map series of Papua New Guinea, compiled from aerial photography, showing minor roads, tracks, water features, buildings and populated places. Relief shown by spot heights.; Produced by National Mapping Office to
Australia. National Mapping Office.
core  

Modulation of habenular and nucleus accumbens functional connectivity by ketamine in major depression

Brain and Behavior
Introduction Major depressive disorder (MDD) is associated with dysfunctional reward processing, which involves functional circuitry of the habenula (Hb) and nucleus accumbens (NAc).
Brandon Taraku, Joana R. Loureiro, Ashish K. Sahib, Artemis Zavaliangos‐Petropulu, Noor Al‐Sharif, Amber M. Leaver, Benjamin Wade, Shantanu Joshi, Roger P. Woods, Randall Espinoza, Katherine L. Narr   +10 more
doaj   +1 more source

Subcortical electrophysiological activity is detectable with high-density EEG source imaging

Nature Communications, 2019
Electroencephalography (EEG) allows the measurement of electrical signals associated with brain activity, but it is unclear if EEG can accurately measure subcortical activity.
Martin Seeber, Lucia-Manuela Cantonas, Mauritius Hoevels, Thibaut Sesia, Veerle Visser-Vandewalle, Christoph M. Michel   +5 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Springvale, Queensland [cartographic material] : Commonwealth Topographic Survey /

, 1961
Provisional ed. Topographic map of Springvale region, Queensland, showing classes of roads, railway and telephone lines, fences, state boundries, watercourses and dams, and windpumps.
Australia. Division of National Mapping.
core  

Brodmann’s Brain Map; The Need for a Modern Brain Map

Journal of Neurology & Stroke, 2016
On 1909, Bordmann proposed his brain map model with 43 areas. In his model, he based on the hypothesis that structures similar in morphology will have similar functions. His model remained the classic brain map for the past century and used to shape our understanding of the brain.
openaire   +1 more source

ACTIVATION OF ASTROCYTES DURING EPILEPTOGENESIS RESTORES ALTERATIONS IN BRAIN GLUCOSE METABOLISM

IBRO Neuroscience Reports, 2023
Nira Hernández Martín, Pablo Bascuñana, Rubén Fernández De La Rosa, Luis García-García, Eduardo Martín, M.A. Pozo   +5 more
doaj   +1 more source