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Xenobiotic metabolism in brain
Toxicology Letters, 1995Recent hypothesis suggesting a role for environmental toxins in the pathogenesis of neurodegenerative disorders has stimulated interest in research on xenobiotic metabolizing capability of the brain. In addition to possible irreversible loss of neurons through bioactivation in situ in the nervous tissue, the metabolism of psychoactive drugs in the ...
V, Ravindranath +5 more
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Molecular and Cellular Biochemistry, 1979
Ceramide is the fundamental structure and key intermediate of all sphingolipids. Biosynthesis and catabolism of brain ceramide, especially their relationship to the metabolism of more complex sphingolipids in brain, are reviewed. Human genetic diseases which involve altered ceramide metabolism are also discussed.
Y, Kishimoto, N, Kawamura
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Ceramide is the fundamental structure and key intermediate of all sphingolipids. Biosynthesis and catabolism of brain ceramide, especially their relationship to the metabolism of more complex sphingolipids in brain, are reviewed. Human genetic diseases which involve altered ceramide metabolism are also discussed.
Y, Kishimoto, N, Kawamura
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Seminars in Pediatric Neurology, 2006
Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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Brain iron uptake is regulated by the expression of transferrin receptor 1 in endothelial cells of the blood-brain barrier. Transferrin-bound iron in the systemic circulation is endocytosed by brain endothelial cells, and elemental iron is released to brain interstitial fluid, likely by the iron exporter, ferroportin.
Tracey A, Rouault, Sharon, Cooperman
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The metabolism of the proteins of the brain
Experientia, 1957Mit Hilfe von isotopem Lysin wurde der Austausch von freiem Lysin zwischen Blut und Gehirn, Leber und Muskel und die Umsatzrate der Eiweisskorper dieser Organe bestimmt.
A, LAJTHA, S, FURST, H, WAELSCH
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Brain Research, 1970
Summary The mammalian brain actively metabolizes inorganic sulfate to 3′-phosphoadenosine 5′-phosphosulfate and a number of sulfated compounds. There are enzymes which desulfate or dephosphorylate 3′-phosphoadenosine 5′-phosphosulfate in the brain.
A S, Balasubramanian, B K, Bachhawat
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Summary The mammalian brain actively metabolizes inorganic sulfate to 3′-phosphoadenosine 5′-phosphosulfate and a number of sulfated compounds. There are enzymes which desulfate or dephosphorylate 3′-phosphoadenosine 5′-phosphosulfate in the brain.
A S, Balasubramanian, B K, Bachhawat
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