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Androgen metabolism in the brain
The Journal of Steroid Biochemistry and Molecular Biology, 1991The paper summarizes the most recent views on androgen metabolism in the brain. In particular it will be shown that: (1) the enzyme 5 alpha-reductase is particularly concentrated in the white matter; (2) 5 alpha-reductase is also present in the myelin; 5 alpha-reductase is present in higher concentrations in neurons (isolated or cultured) that in glial
L. Martini, R. C. Melcangi
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Ethanol metabolism in the brain
Addiction Biology, 1997AbstractAcetaldehyde is suspected of being involved in the central mechanism of central nervous system depression and addiction to ethanol, but in contrast to ethanol, it can not penetrate easily from blood into the brain because of metabolic barriers. Therefore, the possibility of ethanol metabolism and acetaldehyde formation inside the brain has been
S M, Zimatkin, R A, Deitrich
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Metabolic Adaptation in the Brain
Nature, 1970Enzyme adaptation in the brain involving substrates, hormones and neurotransmitters may participate in behavioural adaptation, consolidation in learning and central aspects of drug tolerance. This article is based on lectures given in October 1969 to the Oxford University Biochemical Society and to the Neurochemical Group of the Biochemical Society.
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NITROGEN METABOLISM OF THE BRAIN
Psychiatry and Clinical Neurosciences, 1961Summary A. In order to trace the nitrogen metabolism of the brain, ammonia and glutamine of the rat brain was measured by Conway's microdiffusion method, and aminoacid by the paperchromatography. The following data are the return. 1. In order, the normal rat brain, the contents of following substances range as follows: ammonia 0.62±0.042mg %,
N, OKUMURA, K, KAWAI
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Sulphatide metabolism in brain
Life Sciences, 1977Abstract The galactosulphatides are lipids usually thought to be characteristic of myelin. They have however also been found in non myelin structures of the central nervous system. The synthesis of sulphatide is catalysed by a microsomal sulphotransferase. This enzyme transfers sulphate from active sulphate to cerebroside.
A A, Farooqui, G, Rebel, P, Mandel
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1974
Publisher Summary This chapter explains RNA metabolism in the brain. It discusses the basic cellular metabolic rate of brain as a tissue and in terms of its involvement with certain specialized brain activities, such as electrical processing, axonal transport, neuronal regeneration, and drug interactions.
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Publisher Summary This chapter explains RNA metabolism in the brain. It discusses the basic cellular metabolic rate of brain as a tissue and in terms of its involvement with certain specialized brain activities, such as electrical processing, axonal transport, neuronal regeneration, and drug interactions.
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Cholesterol metabolism in the brain
Current Opinion in Lipidology, 2001The central nervous system accounts for only 2% of the whole body mass but contains almost a quarter of the unesterified cholesterol present in the whole individual. This sterol is largely present in two pools comprised of the cholesterol in the plasma membranes of glial cells and neurons and the cholesterol present in the specialized membranes of ...
J M, Dietschy, S D, Turley
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Brain, Behavior and Evolution, 2008
The interrelationship of brain and body sizes has been the subject of investigations for over a hundred years. These studies have demonstrated that variation in brain weights is much smaller than that in body weights; consequently, scaling studies are ones of negative allometry.
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The interrelationship of brain and body sizes has been the subject of investigations for over a hundred years. These studies have demonstrated that variation in brain weights is much smaller than that in body weights; consequently, scaling studies are ones of negative allometry.
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Metabolic Network of Nucleosides in the Brain
Current Topics in Medicinal Chemistry, 2011Brain relies on circulating nucleosides, mainly synthesised de novo in the liver, for the synthesis of nucleotides, RNA, nuclear and mitochondrial DNA, coenzymes, and pyrimidine sugar- and lipid-conjugates. Essentially, the paths of nucleoside salvage in the brain include a two step conversion of inosine and guanosine to IMP and GMP, respectively, and ...
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1965
Publisher Summary This chapter provides an overview of brain sterol metabolism. Histochemical, cytochemical, developmental, and biochemical studies indicate that much of the brain cholesterol is localized in the lipid–protein layers of the myelin sheath.
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Publisher Summary This chapter provides an overview of brain sterol metabolism. Histochemical, cytochemical, developmental, and biochemical studies indicate that much of the brain cholesterol is localized in the lipid–protein layers of the myelin sheath.
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