Results 81 to 90 of about 3,164,098 (302)

Functional Proteomics and Metabolomics of Brain Energy Metabolism in Pathology and Therapy

open access: yes, 2014
Functional Proteomics and Metabolomics of Brain Energy Metabolism in Pathology and ...
FERRARI, FEDERICA   +2 more
core  

Author Correction: Activation of the unfolded protein response promotes axonal regeneration after peripheral nerve injury

open access: yesScientific Reports, 2021
Maritza Oñate   +7 more
doaj   +1 more source

Suppression of indoleamine-2,3-dioxygenase 1 expression by promoter hypermethylation in ER-positive breast cancer

open access: yesOncoImmunology, 2017
Kynurenine formation by tryptophan-catabolic indoleamine-2,3-dioxygenase 1 (IDO1) plays a key role in tumor immune evasion and inhibition of IDO1 is efficacious in preclinical models of breast cancer. As the response of breast cancer to immune checkpoint
Dyah L. Dewi   +21 more
doaj   +1 more source

Whole-body synthesis secretion of docosahexaenoic acid from circulating eicosapentaenoic acid in unanesthetized rats

open access: yesJournal of Lipid Research, 2009
Dietary docosahexaenoic acid (DHA; 22:6n-3) and eicosapentaenoic acid (EPA; 20:5n-3) are considered important for maintaining normal heart and brain function, but little EPA is found in brain, and EPA cannot be elongated to DHA in rat heart due to the ...
Fei Gao   +5 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

open access: yesFEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti   +5 more
wiley   +1 more source

Circadian Influences on Brain Lipid Metabolism and Neurodegenerative Diseases

open access: yes
Circadian rhythms are intrinsic, 24 h cycles that regulate key physiological, mental, and behavioral processes, including sleep–wake cycles, hormone secretion, and metabolism.
Xiaoyue Pan   +2 more
core   +1 more source

FSH enhances the inflammatory response of macrophages in the knee joint possibly through the NFκB pathway

open access: yesFEBS Open Bio
Previous studies have suggested that women with higher follicle‐stimulating hormone (FSH) levels have a greater incidence of osteoarthritis (OA) compared to women with lower FSH despite normal estrogen levels.
Yu Chen   +6 more
doaj   +1 more source

Rapid synthesis and turnover of brain microsomal ether phospholipids in the adult rat

open access: yesJournal of Lipid Research, 2002
The rates of synthesis, turnover, and half-lives were determined for brain microsomal ether phospholipids in the awake adult unanesthetized rat. A multicompartmental kinetic model of phospholipid metabolism, based on known pathways of synthesis, was ...
Thad A. Rosenberger   +4 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

open access: yesFEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta   +7 more
wiley   +1 more source

Regional differences in brain glucose metabolism determined by imaging mass spectrometry

open access: yes, 2018
Objective: Glucose is the major energy substrate of the brain and crucial for normal brain function. In diabetes, the brain is subject to episodes of hypo- and hyperglycemia resulting in acute outcomes ranging from confusion to seizures, while chronic ...
Heather A. Ferris   +21 more
core   +1 more source

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