Results 71 to 80 of about 3,164,098 (302)

METAL-INDUCED ALTERATIONS OF HEMOPROTEIN METABOLISM IN THE BRAIN.

, 1986
METAL-INDUCED ALTERATIONS OF HEMOPROTEIN METABOLISM IN THE ...
MAZEN KHALIL. QATO (7974404)
core   +4 more sources

Maternal Brown Fat Thermogenesis Programs Glucose Tolerance in the Male Offspring

Cell Reports, 2020
Summary: Environmental temperature is a driving factor in evolution, and it is commonly assumed that metabolic adaptations to cold climates are the result of transgenerational selection.
Rebecca Oelkrug, Christin Krause, Beate Herrmann, Julia Resch, Sogol Gachkar, Alexander T. El Gammal, Stefan Wolter, Oliver Mann, Henrik Oster, Henriette Kirchner, Jens Mittag   +10 more
doaj   +1 more source

The multifaceted roles of lysosomes in cancer

Molecular Oncology, EarlyView.
Lysosomes support cancer cell adaptation by integrating macromolecule degradation and nutrient recycling with nutrient sensing, inter‐organelle communication and immune regulation. These interconnected functions can promote tumour growth, stress tolerance and therapy resistance, while also creating context‐dependent vulnerabilities that may be ...
Jia Li, Kevin M. Ryan
wiley   +1 more source

Brain energy metabolism and its pathologies [PDF]

, 2016
The brain belongs amongst metabolically most active organs and disturbances of brain energy metabolism are commonly cited as a critical factor predisposing to neurodegeneration.
Nová, Jana
core  

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Imaging decreased brain docosahexaenoic acid metabolism and signaling in iPLA2β (VIA)-deficient mice

Journal of Lipid Research, 2010
Ca2+-independent phospholipase A2β (iPLA2β) selectively hydrolyzes docosahexaenoic acid (DHA, 22:6n-3) in vitro from phospholipid. Mutations in the PLA2G6 gene encoding this enzyme occur in patients with idiopathic neurodegeneration plus brain iron ...
Mireille Basselin, Angelo O. Rosa, Epolia Ramadan, Yewon Cheon, Lisa Chang, Mei Chen, Deanna Greenstein, Mary Wohltmann, John Turk, Stanley I. Rapoport   +9 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Bmal1 deficiency in neutrophils alleviates symptoms induced by high-fat diet

iScience
Summary: Physiological processes, including metabolism and immune responses, are generated by the circadian clock, driven by clock genes. Disrupting circadian rhythms through a high-fat diet promotes obesity and inflammation.
Brinja Leinweber, Violetta Pilorz, Iwona Olejniczak, Ludmila Skrum, Kimberly Begemann, Isabel Heyde, Sarah Stenger, Christian David Sadik, Henrik Oster   +8 more
doaj   +1 more source

The presynaptic microtubule cytoskeleton in physiological and pathological conditions: lessons from Fragile X Syndrome and Hereditary Spastic Paraplegias

Frontiers in Molecular Neuroscience, 2016
The capacity of the nervous system to generate neuronal networks relies on the establishment and maintenance of synaptic contacts. Synapses are composed of functionally different presynaptic and postsynaptic compartments.
Felipe Bodaleo, Felipe Bodaleo, Christian Gonzalez-Billault, Christian Gonzalez-Billault, Christian Gonzalez-Billault   +4 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source