Results 51 to 60 of about 3,164,098 (302)

Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders

Brain Sciences, 2018
Males and females sometimes significantly differ in their propensity to develop neurological disorders. Females suffer more from mood disorders such as depression and anxiety, whereas males are more susceptible to deficits in the dopamine system ...
Paulo Pinares-Garcia, Marielle Stratikopoulos, Alice Zagato, Hannah Loke, Joohyung Lee   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat

Journal of Lipid Research, 2008
Whereas antibipolar drug administration to rats reduces brain arachidonic acid turnover, excessive N-methyl-d-aspartate (NMDA) signaling is thought to contribute to bipolar disorder symptoms and may increase arachidonic acid turnover in rat brain ...
Ho-Joo Lee, Jagadeesh S. Rao, Lisa Chang, Stanley I. Rapoport, Richard P. Bazinet   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Music and the brain: disorders of musical listening [PDF]

, 2006
The study of the brain bases for normal musical listening has advanced greatly in the last 30 years. The evidence from basic and clinical neuroscience suggests that listening to music involves many cognitive components with distinct brain substrates ...
Stewart, Lauren, Griffiths, Timothy D., Warren, J., Lauren Stewart, Von Kriegstein, K., Stewart, L., Katharina Von Kriegstein, Timothy D. Griffiths, Griffiths, T., Warren, Jason D., Jason D. Warren, JD, Warren, TD, Griffiths, von Kriegstein, K, Stewart, L; id_orcid   +14 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation [PDF]

, 2013
High frequency deep brain stimulation of the thalamus can help ameliorate severe essential tremor. Here we explore how the efficacy, efficiency and selectivity of thalamic deep brain stimulation might be improved in this condition.
Green, Alexander L, Zrinzo, L, Brittain, John-Stuart, Aziz, Tipu, Green, AL, Zrinzo, Ludvic, Little, S, Cagnan, H, Little, Simon, Limousin, P, Fitzgerald, James, Foltynie, Thomas, Hariz, Marwan, Brittain, JS, Limousin, Patricia, Aziz, T, Brown, Peter, Joint, Carole, Fitzgerald, J, Hariz, M, Cagnan, Hayriye, Foltynie, T, Brown, P, Joint, C   +23 more
core   +1 more source

Functional ability in cognitive complaints: The role of neuropsychiatric and cognitive factors in community‐dwelling older adults

Alzheimer’s & Dementia: Behavior & Socioeconomics of Aging
INTROCUTION The relationship between functional ability and neuropsychiatric or cognitive factors in older adults with cognitive complaints (CCs) remains unexplored in Latin America.
Gonzalo Forno, Pedro Zitko, Patricia Lillo, Daniela Thumala, Fernando Henriquez, Adolfo M. Garcia, Mauricio Cerda, Agustin Ibañez, David Martinez‐Pernia, Eneida Mioshi, Michael Homberger, Mauren Schmitter‐Edgecombe, Andrea Slachevsky   +12 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Glutamine Metabolism in Brain Tumors

, 2019
Altered metabolism is a hallmark of cancer cells. Tumor cells rewire their metabolism to support their uncontrolled proliferation by taking up nutrients from the microenvironment.
Siva Kumar Natarajan, Sriram Venneti
core   +1 more source