Results 41 to 50 of about 3,164,098 (302)

Thyroid hormone receptor beta (THRB) dependent regulation of diurnal hepatic lipid metabolism in adult male mice

npj Metabolic Health and Disease
Thyroid hormones (THs) are critical regulators of systemic energy metabolism and homeostasis. In the liver, high TH action protects against steatosis by enhancing cholesterol and triglyceride turnover, with thyroid hormone receptor beta (THRB) signaling ...
Leonardo Vinicius Monteiro de Assis, Lisbeth Harder, Julica Inderhees, Olaf Jöhren, Jens Mittag, Henrik Oster   +5 more
doaj   +1 more source

Multiple lumbar punctures aiming to relieve headache results in iatrogenic spinal hematoma: a case report

Journal of Medical Case Reports, 2022
Background Multiple lumbar punctures have historically been a strategy to relieve headaches associated with idiopathic intracranial hypertension despite limited clinical evidence of long-term efficacy.
Hannah S. Lyons, Satheesh Ramalingam, James L. Mitchell, Andreas Yiangou, Mark Thaller, Alexandra J. Sinclair, Susan P. Mollan   +6 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Brain networks predict metabolism, diagnosis and prognosis at the bedside in disorders of consciousness [PDF]

, 2017
Recent advances in functional neuroimaging have demonstrated novel potential for informing diagnosis and prognosis in the unresponsive wakeful syndrome and minimally conscious states.
Géraldine Martens, Chennu, Srivas, Olivia Gosseries, Annen, Jitka, Chatelle, Camille, Camille Chatelle, Schnakers, Caroline, Srivas Chennu, Jitka Annen, Caroline Schnakers, Sarah Wannez, Cassol, Helena, Chennu, Shrivas, Thibaut, Aurore, Gosseries, Olivia, Laureys, Steven, Menon, David, Helena Cassol, David Menon, Menon, David K., Steven Laureys, Aurore Thibaut, Wannez, Sarah, Martens, Géraldine   +23 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea A Broadband NIRS Study [PDF]

, 2011
Using broadband near-infrared spectroscopy (NIRS) and cerebral micro-dialysis (MD), we investigated cerebral cellular metabolism and mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI).
Tachtsidis, I, Ghosh, A, Tisdall, MM, Elwell, CE, Pritchard, C, Leung, TS, Smith, M   +6 more
core  

Evidence of the Role of Omega-3 Polyunsaturated Fatty Acids in Brain Glucose Metabolism

, 2020
In mammals, brain function, particularly neuronal activity, has high energy needs. When glucose is supplemented by alternative oxidative substrates under different physiological conditions, these fuels do not fully replace the functions fulfilled by ...
Fabien Pifferi, Stephen C. Cunnane, Philippe Guesnet   +2 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Circadian Gating of Thyroid Hormone Action in Hepatocytes

Cells
Thyroid hormones, thyroxin (T4) and the biologically active triiodothyronine (T3), play important roles in liver metabolic regulation, including fatty acid biosynthesis, beta-oxidation, and cholesterol homeostasis.
Karla Lincoln, Jingxuan Zhou, Henrik Oster, Leonardo Vinicius Monteiro de Assis   +3 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source