Results 71 to 80 of about 227,738 (352)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Factors influencing intensive care unit length of stay after craniotomy for supratentorial tumor resection: an observational study [PDF]

Journal of Neurocritical Care
Background Few studies have explored the intensive care unit (ICU) requirements of patients after craniotomy. Identifying the factors that contribute to extended ICU stay can enhance ICU efficiency and reduce costs. This study investigated the predictors
Abdelghafour El Koundi, Mehdi Samali, Meskine Amine, Khalil Mounir, Hicham Balkhi, Mustapha Bensghir   +5 more
doaj   +1 more source

Chordoid Meningioma: Literature Review

Brazilian Neurosurgery, 2020
Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for ∼ 0.5% of all meningiomas. Chordoid meningioma tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of ...
Carlos Roberto Massella Junior, Marcus Vinicius de Morais, Rafael Pontes Figueiredo, Andrezza Garcia Morales, Paulo Mácio Porto de Melo   +4 more
doaj   +1 more source

An integrated biomarker of PD‐L1 expression and intraepithelial CD8+ T cell infiltration was associated with the prognosis of lung cancer patients after intracranial resection of brain metastases

Thoracic Cancer, 2022
Background Brain metastases (BM) are common in lung cancer. However, data on the status of immune biomarkers in BM lesions remain limited. Methods We retrospectively analyzed PD‐L1 expression and infiltration levels of CD3+, CD4+, CD8+ T cells as ...
Lin‐Lin Li, De‐Xiang Zhou, Ming Lu, Dong Zhou, Xiao‐Feng Lin, Yu Chen, Kai Yin, Hui‐Bo Feng, Wei‐Bang Guo, Zhi Xie, Wen‐Qing Yan, Zhi‐Yi Lv, Dan‐Xia Lu, Shui‐Lian Zhang, Xu‐Chao Zhang   +14 more
doaj   +1 more source

Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features [PDF]

, 2018
Diffuse leptomeningeal glioneuronal tumors (DLGNT) represent rare CNS neoplasms which have been included in the 2016 update of the WHO classification. The wide spectrum of histopathological and radiological features can make this enigmatic tumor entity ...
Brandner, Sebastian, Brück, Wolfgang, Capper, David, Chiang, Jason, Cruz Martinez, Ofelia, Deng, Maximilian Y., Ebinger, Martin, Ellison, David W., Giangaspero, Felice, Gärtner, Jutta, Hansford, Jordan R., Hartmann, Christian, Hernáiz-Driever, Pablo, Jaunmuktane, Zane, Jones, David T. W., Korshunov, Andrey, Leipold, Alfred, Milde, Till, Monoranu, Camelia-Maria, Mora, Jaume, Morales la Madrid, Andres, Nozza, Paolo, Paulus, Werner, Pfister, Stefan M., Pietsch, Torsten, Rüdiger, Thomas, Sahm, Felix, Schittenhelm, Jens, Schuhmann, Martin U., Sill, Martin, Sommer, Clemens, Stoler, Iris, Tietze, Anna, von Deimling, Andreas, Wittmann, Andrea   +34 more
core   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence

Molecular Oncology, EarlyView.
The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova, Dominika Maurencova, Barbora Salovska, Marek Kratky, Tomas Mracek, Zuzana Korandova, Alena Pecinova, Pavla Vasicova, David Rysanek, Ladislav Andera, Ivo Fabrik, Rudolf Kupcik, Pavel Kashmel, Pinky Sultana, Vojtech Tambor, Jiri Bartek, Josef Novak, Marie Vajrychova, Zdenek Hodny   +18 more
wiley   +1 more source

Preterm delivery in a patient with frontal lobe brain tumor [PDF]

Vojnosanitetski Pregled, 2009
Introduction/Aim. Brain tumors are very rare in pregnancy. Diagnosis could be very simple if one consider brain tumor alongside blurred symptoms of headache, repetitive vomiting and/or epileptic attacks during pregnancy.
Čutura Neđo, Soldo Vesna
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source