Results 1 to 10 of about 1,563,845 (118)

A Hidden Markov Model reveals magnetoencephalography spectral frequency-specific abnormalities of brain state power and phase-coupling in neuropathic pain

Communications Biology, 2022
A comparative analysis on resting-state magnetoencephalography data from healthy controls and patients with chronic pain reveals spectral frequency-specific dysregulation and a temporal imbalance of brain microstates in chronic neuropathic pain.
Camille Fauchon, Junseok A. Kim, Rima El-Sayed, Natalie R. Osborne, Anton Rogachov, Joshua C. Cheng, Kasey S. Hemington, Rachael L. Bosma, Benjamin T. Dunkley, Jiwon Oh, Anuj Bhatia, Robert D. Inman, Karen Deborah Davis   +12 more
doaj   +1 more source

Diversity amongst human cortical pyramidal neurons revealed via their sag currents and frequency preferences

Nature Communications, 2021
The unique biophysical properties of human cortical neurons that may underlie interlaminar communication are explored. With a focus on I h and layers 2&3, 3c, and 5, the authors show that L5 pyramidal neurons are better adapted than their superficial ...
Homeira Moradi Chameh, Scott Rich, Lihua Wang, Fu-Der Chen, Liang Zhang, Peter L. Carlen, Shreejoy J. Tripathy, Taufik A. Valiante   +7 more
doaj   +1 more source

Ready to detect a reversal of time's arrow: a psychophysical study using short video clips in daily scenes

Royal Society Open Science, 2023
It is generally believed that time flows in one direction and that a reversal of time's arrow would render the external world non-sensical. We evaluated our ability to tell the direction of time's arrow in a wide range of dynamic scenes in our daily life
Nao Hanyu, Kei Watanabe, Shigeru Kitazawa   +2 more
doaj   +1 more source

The Potential Clinical Utility of Pressure-Based vs. Heat-Based Paradigms to Measure Conditioned Pain Modulation in Healthy Individuals and Those With Chronic Pain

Frontiers in Pain Research, 2021
Conditioned pain modulation (CPM) is a physiological measure thought to reflect an individual's endogenous pain modulation system. CPM varies across individuals and provides insight into chronic pain pathophysiology.
Rima El-Sayed, Rima El-Sayed, Camille Fauchon, Junseok A. Kim, Junseok A. Kim, Shahrzad Firouzian, Shahrzad Firouzian, Natalie R. Osborne, Natalie R. Osborne, Ariana Besik, Emily P. Mills, Anuj Bhatia, Anuj Bhatia, Karen D. Davis, Karen D. Davis, Karen D. Davis   +15 more
doaj   +1 more source

Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans

Molecular Neurodegeneration, 2021
Background Parkinson’s disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers.
Kevin S. Chen, Krystal Menezes, Jarlath B. Rodgers, Darren M. O’Hara, Nhat Tran, Kazuko Fujisawa, Seiya Ishikura, Shahin Khodaei, Hien Chau, Anna Cranston, Minesh Kapadia, Grishma Pawar, Susan Ping, Aldis Krizus, Alix Lacoste, Scott Spangler, Naomi P. Visanji, Connie Marras, Nour K. Majbour, Omar M. A. El-Agnaf, Andres M. Lozano, Joseph Culotti, Satoshi Suo, William S. Ryu, Suneil K. Kalia, Lorraine V. Kalia   +25 more
doaj   +1 more source

The Protein Kinase Inhibitor Midostaurin Improves Functional Neurological Recovery and Attenuates Inflammatory Changes Following Traumatic Cervical Spinal Cord Injury

Biomolecules, 2021
Traumatic spinal cord injury (SCI) impairs neuronal function and introduces a complex cascade of secondary pathologies that limit recovery. Despite decades of preclinical and clinical research, there is a shortage of efficacious treatment options to ...
Mohammad-Masoud Zavvarian, James Hong, Mohamad Khazaei, Jonathon Chon Teng Chio, Jian Wang, Anna Badner, Michael G. Fehlings   +6 more
doaj   +1 more source

Frequency-based brain networks: From a multiplex framework to a full multilayer description [PDF]

, 2017
We explore how to study dynamical interactions between brain regions using functional multilayer networks whose layers represent the different frequency bands at which a brain operates.
Buldú, Javier M., Porter, Mason A.
core   +2 more sources

Identifying and modulating distinct tremor states through peripheral nerve stimulation in Parkinsonian rest tremor

Journal of NeuroEngineering and Rehabilitation, 2021
Background Resting tremor is one of the most common symptoms of Parkinson’s disease. Despite its high prevalence, resting tremor may not be as effectively treated with dopaminergic medication as other symptoms, and surgical treatments such as deep brain ...
Beatriz S. Arruda, Carolina Reis, James J. Sermon, Alek Pogosyan, Peter Brown, Hayriye Cagnan   +5 more
doaj   +1 more source

Brain networks under attack : robustness properties and the impact of lesions [PDF]

, 2016
A growing number of studies approach the brain as a complex network, the so-called ‘connectome’. Adopting this framework, we examine what types or extent of damage the brain can withstand—referred to as network ‘robustness’—and conversely, which kind of ...
Aerts, Hannelore, Caeyenberghs, Karen, Fias, Wim, Marinazzo, Daniele   +3 more
core   +2 more sources

Controllability of structural brain networks. [PDF]

, 2015
Cognitive function is driven by dynamic interactions between large-scale neural circuits or networks, enabling behaviour. However, fundamental principles constraining these dynamic network processes have remained elusive.
Bassett, Danielle S, Cieslak, Matthew, Grafton, Scott T, Gu, Shi, Kahn, Ari E, Medaglia, John D, Miller, Michael B, Pasqualetti, Fabio, Telesford, Qawi K, Vettel, Jean M, Yu, Alfred B   +10 more
core   +1 more source