Results 81 to 90 of about 919,937 (353)
The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells
FEBS Open Bio, EarlyView.We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel +8 more
wiley +1 more source
The prefrontal operculum, a human-specific hub for the cognitive control of speech
Communications BiologyCurrent theories fail to explain why the ability to control speech is unique to humans. We recently identified one unique feature in the human frontal cortex that may hold the key to this question: the Prefrontal Operculum (PFO).
Charles Verstraete +10 more
doaj +1 more source
Cell Reports, 2016 The molecular linkage between neocortical projection neuron subtype and area development, which enables the establishment of functional areas by projection neuron populations appropriate for specific sensory and motor functions, is poorly understood ...
Mollie B. Woodworth +5 more
doaj +1 more source
Intrinsic neural stem cell properties define brain hypersensitivity to genotoxic stress [PDF]
, 2022 Argyro Kalogeropoulou +13 more
openalex +1 more source
Stem cells and the origin of gliomas: A historical reappraisal with molecular advancements. [PDF]
, 2009 The biology of both normal and tumor development clearly possesses overlapping and parallel features. Oncogenes and tumor suppressors are relevant not only in tumor biology, but also in physiological developmental regulators of growth and differentiation.
Ho, Allen L +4 more
core +3 more sources
Implications of ischemic penumbra for the diagnosis of brain death [PDF]
, 1999 The data reviewed here suggest the possibility that a global reduction of blood supply to the whole brain or solely to the infratentorial structures down to the range of ischemic penumbra for several hours or a few days may lead to misdiagnosis of ...
Coimbra, Cicero Galli
core +5 more sources
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
Adult neurogenesis 20 years later: physiological function vs. brain repair [PDF]
, 2015 The discovery that mammalian brains contain neural stem cells which perform adult neurogenesis - the production and integration of new neurons into mature neural circuits - has provided a fully new vision of neural plasticity.
Luca Bonfanti, Paolo Peretto
core +2 more sources
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source
OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma
Nature CommunicationsFunctional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in a dysregulated ...
Kinjal Desai +18 more
doaj +1 more source