Results 81 to 90 of about 933,949 (357)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
OLIG2 mediates a rare targetable stem cell fate transition in sonic hedgehog medulloblastoma
Nature CommunicationsFunctional cellular heterogeneity in tumours often underlies incomplete response to therapy and relapse. Previously, we demonstrated that the growth of the paediatric brain malignancy, sonic hedgehog subgroup medulloblastoma, is rooted in a dysregulated ...
Kinjal Desai +18 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Patologìâ, 2019 The aim of our study was to determine the characteristics of the BNP and AT II expression in the LC structure of rat brain stem with experimental (genetically determined essential and secondary endocrine-salt) arterial hypertension and to give a ...
M. V. Danukalo +2 more
doaj +1 more source
The systemic environment: at the interface of aging and adult neurogenesis. [PDF]
, 2017 Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle.
Smith, Lucas K +2 more
core +1 more source
BMJ, 1996 I set out on the half term holiday with the family, blissfully unaware of the traumatic events that were to follow. We had borrowed a friend's weekend cottage and I went to bed early. My only medical condition was a persistent headache, but I had had headaches before as I occasionally suffered from migraine.
openaire +2 more sources
FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
Acoustic evoked potentials characteristics in patients with vertebral artery hypoplasia and posterior circulation stroke [PDF]
Vojnosanitetski PregledBackground/Aim. Acoustic evoked potentials (AEPs) represent an electrophysiological method used in diagnosing pathological changes of the brain stem (BSt), the acoustic nerve (its peripheral and central part), in patients in coma, in the confirmation of ...
Živadinović Biljana +8 more
doaj +1 more source
Neural Development: Brain stems [PDF]
Current Biology, 1995 The discovery of stem cells in adult nerve tissue makes the repair of brain damage a realistic possibility.
openaire +2 more sources
FEBS Open Bio, EarlyView.Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah +8 more
wiley +1 more source