Results 201 to 210 of about 128,934 (249)

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

The Elusive Origin of Glioblastoma: Where Do We Stand? [PDF]

Cells
Pernia Marin M, Almabrok H, Miller ML, Haggiagi A.   +3 more
europepmc   +1 more source

Developing Micro/Nanostructured Fluidic Mixing Technology for Biomedical Applications

Advanced Science, EarlyView.
This review critically evaluates how micro/nanostructured mixing technologies are redefining biomedical research. By synergizing fundamental analysis, numerical modeling, structural design, and external field manipulation, these systems attain unprecedented control over mass transport.
Junkai Wang, Hanxu Chen, Yile Fang, Yuanjin Zhao   +3 more
wiley   +1 more source

DMRTA2 Regulates Radial Glial Maintenance and Tumorigenicity of Paediatric High-Grade Glioma. [PDF]

J Cell Mol Med
Royston HN, Hampton AB, Oliver EG, Jackson J, Tella I, Emerson MD, Bhagat D, Zimmerman GE, Konno D, Funato K.   +9 more
europepmc   +1 more source

A Bone Marrow–Mimetic Hydrogel Enables Dual‐Phase Hemostasis and Vascularized Osteogenesis for Cranial Defects

Advanced Science, EarlyView.
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che, Donghong Li, Huan Zhang, Tingting Xu, Juhan Li, Xuanzhou Chen, Louis D. Zhang, Shuguang Wang, Dianwen Song, Dongyong Sha   +9 more
wiley   +1 more source

Temporal bone mass as the initial presentation of peripheral T-cell lymphoma in an infant: a case report. [PDF]

BMC Pediatr
Forero-Sanchez AS, Yepes-Madrid N, Gómez-Urrego JF, Segura-Galvis RA, Caicedo-Estrada CA.   +4 more
europepmc   +1 more source

STAID: A Self‐Refining Deep Learning Framework for Spatial Cell‐Type Deconvolution with Biologically Informed Modeling

Advanced Science, EarlyView.
STAID is a unified deep learning framework that couples iterative pseudo‐spot refinement with neural network training through a feedback loop and exploits gene co‐expression information to model higher‐order interactions, achieving accurate and robust cell‐type deconvolution in spatial transcriptomics.
Jixin Liu, Shuli Sun, Zhengliang Lv, Xinyu Liu, Yihua Wang, Bingqiang Liu   +5 more
wiley   +1 more source

Extracellular Vesicles: A Mailcoach From Mast Cell to Other Cell Species. [PDF]

Immun Inflamm Dis
Zhang B, Sun Y, Jiang T, Long R, Guo Y.
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

Mesenchymal Stem Cells Membrane Biomimetic Nanoplatform for Glioblastoma-Targeted Combinatorial Chemotherapy. [PDF]

Int J Nanomedicine
Li Y, Jin T, Guan X, Han C, Zou W, Shen L, Liu J.   +6 more
europepmc   +1 more source