Results 91 to 100 of about 1,087,620 (371)

Neurotoxic amyloid β‐peptide and tau produce cytokine‐like effects on PMCA in glioblastoma cell lines, enhancing its activity and isoforms expression

FEBS Open Bio, EarlyView.
Two biomarkers of Alzheimer's disease, amyloid β‐peptide (Aβ) and tau, induce the transformation of U‐251 and other glioblastoma cell lines into neurotoxic A1‐like reactive astrocytes. This transformation is produced by cytokines and is followed by upregulation of PMCA activity and isoform expression, and is closely associated with inflammation, as ...
María Berrocal, Alberto Alvarez‐Barrientos, Ana M. Mata   +2 more
wiley   +1 more source

Where Are the fMRI Correlates of Phosphene Perception?

Frontiers in Neuroscience, 2018
Pulses of transcranial magnetic stimulation (TMS) over occipital cortex can induce transient visual percepts called phosphenes. Phosphenes are an interesting stimulus for the study of the human visual system, constituting conscious percepts without ...
Tom A. de Graaf, Tom A. de Graaf, Job van den Hurk, Job van den Hurk, Felix Duecker, Felix Duecker, Alexander T. Sack, Alexander T. Sack   +7 more
doaj   +1 more source

Iron‐dependent lysosomal LDL oxidation induces the expression of scavenger receptor A in human THP‐1 monocytes

FEBS Open Bio, EarlyView.
In human monocytic cells THP‐1, a limited uptake of native—not oxidized—LDL/VLDL induced expression of scavenger receptor A and cellular adhesion. Induction was inhibited by lysosomotropic (WR‐1065) and lipophilic (BHT) antioxidants and by siRNAs against ferritinophagy.
Martina Čierna, Richard Buchal, Martin Leníček, Amit Shachak, Jan Pláteník   +4 more
wiley   +1 more source

LTP-like cortical plasticity predicts conversion to dementia in patients with memory impairment

Brain Stimulation, 2020
Background: New diagnostic criteria consider Alzheimer’s disease (AD) as a clinico-biological entity identifiable in vivo on the presence of specific patterns of CSF biomarkers. Objective: Here we used transcranial magnetic stimulation to investigate the
Francesco Di Lorenzo, Caterina Motta, Elias Paolo Casula, Sonia Bonnì, Martina Assogna, Carlo Caltagirone, Alessandro Martorana, Giacomo Koch   +7 more
doaj  

Mapping effective connectivity by virtually perturbing a surrogate brain [PDF]

arXiv, 2022
Effective connectivity (EC), indicative of the causal interactions between brain regions, is fundamental to understanding information processing in the brain. Traditional approaches, which infer EC from neural responses to stimulations, are not suited for mapping whole-brain EC in humans due to being invasive and having limited spatial coverage of ...
arxiv  

TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain [PDF]

, 2016
Background: The relationship between the brain and the immune system has become increasingly topical as, although it is immune-specialised, the CNS is not free from the influences of the immune system.
A Boivin, A Constant, A Walter, AD Bachstetter, Alison McColl, B Winner, BT Fife, C Callewaere, C D'Mello, C Gemma, CA Thomson, Carolyn A. Thomson, CP Marques, CS McKimmie, CT Ekdahl, D Michlmayr, D Michlmayr, EE Ubogu, G Banisadr, G Banisadr, Gerard J. Graham, JH Dufour, JL Teeling, Jonathan Cavanagh, JS Cameron, JS Snyder, JT Rogers, L Azzi, L Cartier, L Fits van der, Louis Nerurkar, M Baggiolini, M Udina, ML Monje, MM Lee, N Andrews, Q Liu, R Dantzer, R Deacon, R Krishnan, R Rola, RM Deacon, RM Ransohoff, S Baraldi, S Goethals, S Potvin, S Tyring, SM O'Brien, U Patel, U Puntener, W Huang da, W Huang da, W Rostene, WJ Karpus   +53 more
core   +2 more sources

The role of circular RNAs in regulating cytokine signaling in cancer

FEBS Open Bio, EarlyView.
Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi, Swati, Amit Mishra, Amaresh Panda, Vivek Sharma   +4 more
wiley   +1 more source

Stimulation-based control of dynamic brain networks [PDF]

arXiv, 2016
The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation, much remains unknown about the network-level impact of these focal perturbations. To study the system wide impact
arxiv  

A computational model for real-time calculation of electric field due to transcranial magnetic stimulation in clinics [PDF]

, 2015
The aim of this paper is to propose an approach for an accurate and fast (real-time) computation of the electric field induced inside the whole brain volume during a transcranial magnetic stimulation (TMS) procedure. The numerical solution implements the
Apollonio, Francesca, Camera, Francesca, Carducci, Filippo, Liberti, Micaela, Paffi, Alessandra, Rubino, Gianluigi, Tampieri, Paolo   +6 more
core   +3 more sources

Biophysical characterization and ion transport with cell‐based and proteoliposome reconstitution assays of invertebrate K+‐Cl− cotransporters

FEBS Open Bio, EarlyView.
The K+‐Cl− cotransporters (KCCs) facilitate the symport of ions across the plasma membrane. They participate in physiological processes including neuronal regulation. Here, we characterized KCCs from Drosophila and Hydra vulgaris. Comparative analyses of transporters provide insights into the mechanism of KCC ion transport, regulation, and evolution ...
Satoshi Fudo, Marina Verkhovskaya, Coralie Di Scala, Claudio Rivera, Tommi Kajander   +4 more
wiley   +1 more source